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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 465 -468. doi: 10.3877/cma.j.issn.1674-0785.2020.06.013

所属专题: 文献

综述

肠内免疫营养在胃肠道肿瘤围手术期的临床应用
王蕾1, 张颖1, 王立彬2, 陈强谱2,()   
  1. 1. 256600 山东滨州,滨州医学院附属医院临床营养科
    2. 256600 山东滨州,滨州医学院附属医院肝胆外科
  • 收稿日期:2019-12-04 出版日期:2020-06-15
  • 通信作者: 陈强谱
  • 基金资助:
    山东省普外科临床重点专科建设基金资助项目(ZDZK2013SJ09); 动态性营养风险筛查和营养支持对围手术期喉癌患者临床转归的研究(2017WSB30057)

Clinical application of enteral immunonutrition in the perioperative period of gastrointestinal cancer surgery

Lei Wang1, Ying Zhang1, Libin Wang2, Qiangpu Chen2,()   

  1. 1. Department of Clinical Nutrition, Binzhou Medical University Hospital, Binzhou 256600, China
    2. Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou 256600, China
  • Received:2019-12-04 Published:2020-06-15
  • Corresponding author: Qiangpu Chen
  • About author:
    Corresponding author: Chen Qiangpu, Email:
引用本文:

王蕾, 张颖, 王立彬, 陈强谱. 肠内免疫营养在胃肠道肿瘤围手术期的临床应用[J/OL]. 中华临床医师杂志(电子版), 2020, 14(06): 465-468.

Lei Wang, Ying Zhang, Libin Wang, Qiangpu Chen. Clinical application of enteral immunonutrition in the perioperative period of gastrointestinal cancer surgery[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(06): 465-468.

胃肠道肿瘤患者常存在营养不良,手术应激可加重其营养不良程度并导致免疫功能紊乱,改善围手术期的免疫营养状态是减少免疫相关并发症、加速患者康复的重要手段,肠内免疫营养是围手术期调节免疫系统活性的新方法。本文综述了免疫营养制剂种类和胃肠道肿瘤患者营养障碍的机制,主要介绍了肠内免疫营养在不同胃肠道肿瘤围手术期的临床应用。

Patients with gastrointestinal cancer often suffer from malnutrition. Surgical stress can aggravate the degree of malnutrition and lead to immune dysfunction. Improving the perioperative immune nutritional status is an important means to reduce immune related complications and accelerate the recovery of patients. Enteral immunonutrition is a new method to regulate the activity of the immune system in the perioperative period. This paper reviews the types of immunonutrition agents and the mechanism of perioperative nutritional disorders in patients with gastrointestinal cancer, with an emphasis put on the clinical application in the perioperative period of surgery for different gastrointestinal cancers.

1
Cheng Y, Zhang J, Zhang L, et al. Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis [J]. BMC Gastroenterol, 2018, 18(1): 11.
2
Wong CS, Aly EH. The effects of enteral immunonutrition in upper gastrointestinal surgery: a systematic review and meta-analysis [J]. Int J Surg, 2016, 29(Suppl 1): 137-150.
3
Probst P, Ohmann S, Klaiber U, et al. Meta-analysis of immunonutrition in major abdominal surgery [J]. Br J Surg, 2017, 104(12): 1594-1608.
4
Zhang B, Najarali Z, Ruo L, et al. Effect of perioperative nutritional supplementation on postoperative complications-systematic review and meta-analysis [J]. J Gastrointest Surg, 2019, 23(8): 1682-1693.
5
Torgersen Z, Balters M. Perioperative nutrition [J]. Surg Clin North Am, 2015, 95(2): 255-267.
6
Drover JW, Dhaliwal R, Weitzel L, et al. Perioperative use of arginine-supplemented diets: a systematic review of the evidence [J]. J Am Coll Surg, 2011, 212(3): 385-399, 399.e1.
7
Chattopadhyay P, Shukla G, Wahi AK. Protective effect of L-arginine against necrosis and apoptosis induced by experimental ischemic and reperfusion in rat liver [J]. Saudi J Gastroenterol, 2009, 15(3): 156-162.
8
Enomoto TM, Larson D, Martindale RG. Patients requiring perioperative nutritional support [J]. Med Clin North Am, 2013, 97(6): 1181-1200.
9
管清海,张长习,陈强谱. 免疫营养制剂的临床应用 [J]. 临床药物治疗杂志, 2013, 11(2): 32-36.
10
Plank LD, Mathur S, Gane EJ, et al. Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial [J]. Hepatology, 2015, 61(2): 639-647.
11
Russell K, Zhang HG, Gillanders LK, et al. Preoperative immunonutrition in patients undergoing liver resection: a prospective randomized trial [J]. World J Hepatol, 2019, 11(3): 305-317.
12
Suzuki D, Furukawa K, Kimura F, et al. Effects of perioperative immunonutrition on cell-mediated immunity, T helper type 1 (Th1)/Th2 differentiation, and Th17 response after pancreaticoduodenectomy [J]. Surgery, 2010, 148(3): 573-581.
13
Blumenstein I. GLP-2 analogues as first specific treatment of intestinal failure [J]. Visc Med, 2019, 35(5): 320-323.
14
Jeppesen PB, Sanguinetti EL, Buchman A, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients [J]. Gut, 2005, 54(9): 1224-1231.
15
Pape UF, Maasberg S, Pascher A. Pharmacological strategies to enhance adaptation in intestinal failure [J]. Curr Opin Organ Transplant, 2016, 21(2): 147-152.
16
张长习,陈强谱,张兴元. 免疫肠内营养的临床应用及评价 [J/CD]. 中华临床医师杂志(电子版), 2011, 5(12): 3417-3420.
17
Meng M, Chen S, Lao T, et al. Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells [J]. Cell Cycle, 2010, 9(19): 3921-3932.
18
Ban K, Kozar RA. Glutamine protects against apoptosis via downregulation of Sp3 in intestinal epithelial cells [J]. Am J Physiol Gastrointest Liver Physiol, 2010, 299(6): G1344-1353.
19
Wischmeyer PE, Carli F, Evans DC, et al. American society for enhanced recovery and perioperative quality initiative joint consensus statement on nutrition screening and therapy within a surgical enhanced recovery pathway [J]. Anesth Analg, 2018, 126(6): 1883-1895.
20
Blackburn GL. Metabolic considerations in management of surgical patients [J]. Surg Clin North Am, 2011, 91(3): 467-480.
21
Tan HB, Danilla S, Murray A, et al. Immunonutrition as an adjuvant therapy for burns [J]. Cochrane Database Syst Rev, 2014(12): CD007174.
22
Williams DGA, Molinger J, Wischmeyer PE. The malnourished surgery patient: a silent epidemic in perioperative outcomes? [J]. Curr Opin Anaesthesiol, 2019, 32(3): 405-411.
23
Bisch S, Nelson G, Altman A. Impact of nutrition on enhanced recovery after surgery (ERAS) in gynecologic oncology [J]. Nutrients, 2019, 11(5): 1088.
24
Song GM, Liu XL, Bian W, et al. Systematic review with network meta-analysis: comparative efficacy of different enteral immunonutrition formulas in patients underwent gastrectomy [J]. Oncotarget, 2017, 8(14): 23376-23388.
25
Klek S, Szybinski P, Szczepanek K. Perioperative immunonutrition in surgical cancer patients: a summary of a decade of research [J]. World J Surg, 2014, 38(4): 803-812.
26
Cui M, Liao Q, Zhao Y. Enteral immunonutrition promotes immune and inflammatory recovery after surgery for gastric cancer [J]. J Invest Surg, 2019: 1-2.
27
Xu J, Sun X, Xin Q, et al. Effect of immunonutrition on colorectal cancer patients undergoing surgery: a meta-analysis [J]. Int J Colorectal Dis, 2018, 33(3): 273-283.
28
Moya P, Soriano-Irigaray L, Ramirez JM, et al. Perioperative standard oral nutrition supplements versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) protocol: a multicenter randomized clinical trial (SONVI Study) [J]. Medicine (Baltimore), 2016, 95(21): e3704.
29
Sanchez-Guillen L, Arroyo A. Immunonutrition in patients with colon cancer [J]. Immunotherapy, 2020, 12(1): 5-8.
30
Moya P, Miranda E, Soriano-Irigaray L, et al. Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection [J]. Surg Endosc, 2016, 30(11): 4946-4953.
31
Achilli P, Mazzola M, Bertoglio CL, et al. Preoperative immunonutrition in frail patients with colorectal cancer: an intervention to improve postoperative outcomes [J]. Int J Colorectal Dis, 2020, 35(1): 19-27.
32
Wigmore SJ, Ross JA, Falconer JS, et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer [J]. Nutrition, 1996, 12(1 Suppl): S27-S30.
33
Gade J, Levring T, Hillingsø J, et al. The effect of preoperative oral immunonutrition on complications and length of hospital stay after elective surgery for pancreatic cancer--a randomized controlled trial [J]. Nutr Cancer, 2016, 68(2): 225-233.
34
Okabayashi T, Iyoki M, Sugimoto T, et al. Oral supplementation with carbohydrate- and branched-chain amino acid-enriched nutrients improves postoperative quality of life in patients undergoing hepatic resection [J]. Amino Acids, 2011, 40(4): 1213-1220.
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