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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (07) : 569 -572. doi: 10.3877/cma.j.issn.1674-0785.2020.07.020

所属专题: 经典病例 文献

病例研究

相同单体核型恶性血液病二例治疗体会并文献复习
白观臣1, 刘玉玉1, 高苗苗1, 高思凤1, 张继磊1, 滕清良1,()   
  1. 1. 271000 泰安市中心医院血液内科
  • 收稿日期:2019-11-17 出版日期:2020-07-15
  • 通信作者: 滕清良

Treatment of hematologic malignancies with same monosomal karyotype: Report of two cases and review of the literature

Guanchen Bai1, Yuyu Liu1, Miaomiao Gao1, Sifeng Gao1, Jilei Zhang1, Qingliang Teng1,()   

  1. 1. Deparment of Hematologhy, the Tai′an City Center Hospital, Tai′an 271000, China
  • Received:2019-11-17 Published:2020-07-15
  • Corresponding author: Qingliang Teng
  • About author:
    Corresponding author: Teng Qingliang, Email:
引用本文:

白观臣, 刘玉玉, 高苗苗, 高思凤, 张继磊, 滕清良. 相同单体核型恶性血液病二例治疗体会并文献复习[J/OL]. 中华临床医师杂志(电子版), 2020, 14(07): 569-572.

Guanchen Bai, Yuyu Liu, Miaomiao Gao, Sifeng Gao, Jilei Zhang, Qingliang Teng. Treatment of hematologic malignancies with same monosomal karyotype: Report of two cases and review of the literature[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(07): 569-572.

目的

报道2例del(5)恶性血液病的不同治疗过程,通过文献复习探讨不同治疗方式。

方法

分别采用雷利度胺及地西他滨为基础的治疗方案,观察患者的血象、临床表现及细胞遗传学的变化。

结果

2例患者采用不同的治疗方案,均获得细胞遗传学缓解。

结论

相同的单体核型在不同疾病具有不同的预后价值,依据指南治疗才能取得良好效果。

Objective

To assess the therapeutic effects of different regimens in two hematologic malignancy patients with del (5) and perform a review of the literature.

Methods

The changes of blood para, clinical manifestations, and cytogenetics were investigated in two patients with hematologic malignancies who were treated with lenalidomide and decitabine-based regimens, respectively.

Results

Although the two patients received different treatments, they both achieved cytogenetic remission.

Conclusion

The same monosomal karyotype may predict different prognoses in different diseases, and treatment based on guidelines should be adopted in order to achieve good results.

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