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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (11) : 866 -871. doi: 10.3877/cma.j.issn.1674-0785.2020.11.003

所属专题: 乳腺疾病 文献

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CSCO乳腺癌HR阳性晚期乳腺癌内分泌治疗的进展
徐凡1, 贾晓萌1, 郑园园1, 徐岭植1,(), 李曼1,()   
  1. 1. 116023 辽宁大连,大连医科大学附属第二医院肿瘤内科
  • 收稿日期:2020-09-16 出版日期:2020-11-15
  • 通信作者: 徐岭植, 李曼
  • 基金资助:
    国家自然科学基金项目(81872156,81602588); 辽宁省自然科学基金项目(2019-MS-096); 大连市科技创新基金项目(2019J13SN87)

Update on endocrine therapy for hormonal receptor positive advanced breast cancer

Fan Xu1, Xiaomeng Jia1, Yuanyuan Zheng1, Lingzhi Xu1,(), Man Li1,()   

  1. 1. Department of Oncology, the Second Hospital of Dalian Medical University, Dalian 116023, China
  • Received:2020-09-16 Published:2020-11-15
  • Corresponding author: Lingzhi Xu, Man Li
引用本文:

徐凡, 贾晓萌, 郑园园, 徐岭植, 李曼. CSCO乳腺癌HR阳性晚期乳腺癌内分泌治疗的进展[J]. 中华临床医师杂志(电子版), 2020, 14(11): 866-871.

Fan Xu, Xiaomeng Jia, Yuanyuan Zheng, Lingzhi Xu, Man Li. Update on endocrine therapy for hormonal receptor positive advanced breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(11): 866-871.

随着有关CDK4/6抑制剂、HDAC抑制剂、PI3K/Akt/mTOR抑制剂临床研究的不断深入,激素受体阳性晚期乳腺癌的内分泌治疗进入了靶向联合时代。面对诸多新型药物,如何制定最优化和个体化的治疗方案成为广大临床医生关注的焦点。2020年新版CSCO乳腺癌指南充分考量循证医学证据等级、治疗手段可及性及最新研究进展,并针对既往用药情况提出分层策略,对激素受体阳性晚期乳腺癌的内分泌治疗方案予以相应推荐,为广大乳腺癌医学工作者在临床实践中作出合理选择提供了指导依据。

With the constant progress of clinical trials on innovative drugs such as CDK 4/6 inhibitors, HDAC inhibitors, and PI3K/Akt/mTOR inhibitors, endocrine therapy for hormonal receptor positive advanced breast cancer has entered the era of targeted combination therapy. Facing with various targeted therapeutic drugs, determining the optimal and individualized treatment has become the main focus for clinicians. The updated 2020 version of Chinese Society of Clinical Oncology Breast Cancer guidelines fully take into account the evidence level of evidence-based medicine, changes in drug accessibility, and latest research progress, and propose stratified strategies based on the previous history of endocrine treatment, and recommend endocrine treatment options for hormone receptor-positive advanced breast cancer, providing a guiding basis for the majority of breast cancer medical workers to make reasonable choices in clinical practice.

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