microRNAs调控糖尿病肾病发展的研究进展

doi:10.3877/cma.j.issn.1674-0785.2021.02.010

随着糖尿病发病率逐年上升，其并发症也愈发受到关注，其中糖尿病肾病（DKD）是由糖尿病引起的慢性肾脏疾病，发病机制复杂，目前暂无特异性的有效治疗手段，且预后差。microRNAs（miRNAs）是近年来新发现的非编码单链小RNA，可通过调控靶基因影响DKD肾组织的病理特征，调节DKD的发生、发展机制。就目前研究来看，某种特异性的miRNA将有望成为早期诊断DKD的分子标志物，且可能成为DKD潜在的治疗靶点。故本文就miRNAs参与调控糖尿病肾病发生、发展的相关研究做一综述。

关键词: 糖尿病肾病, 微小RNAs, 发病机制

As the incidence of diabetes has increased year by year, its complications have also received increasing attention. Diabetic kidney disease (DKD) is a chronic kidney disease caused by diabetes and its pathogenesis is complicated. Currently, there is no specific and effective treatment for DKD, and as a result, its prognosis is poor. MicroRNAs (miRNAs) are non-coding single-stranded small RNAs discovered in recent years, which can affect the pathological characteristics of kidney tissue by regulating target genes, and regulate the occurrence and development of DKD. Based on current research, certain specific miRNAs are expected to become diagnostic biomarkers and therapeutic targets for DKD. Therefore, this article reviews the related research on miRNAs involved in the regulation of the occurrence and development of DKD.

Key words: Diabetic kidney disease, MicroRNA, Pathogenesis

表1 可能参与糖尿病肾病发生发展的miRNAs

作用	microRNAs
促进糖尿病肾病发展	miR-1207-5p、miR-124、miR-125b、miR-126、miR-133b、miR-135a、miR-141、miR-155、miR-181a/d、miR-184、miR-192、miR-199b、miR-let7b-5p 、miR-200b/c、miR-21、miR-214、miR-216a、miR-217、miR-22、miR-27a、miR-29c、miR-34a、miR-370、miR-377、miR-503、miR-770、miR-130b、miR-320c、miR-4490、miR-488、miR-101
抑制糖尿病肾病发展	miR-let7c-5p、miR-192、miR-1915-3p、miR-16、miR-146a、miR-130b、miR-126、miR-200a、miR-23b、miR-25、miR-26a、miR-29家族、miR-30家族、miR-33-5p、miR-346a、miR-374a、miR-424、miR-451、miR-4532、miR-93、miR-124、miR-342、miR-1228-3p、miR-27b-3p、miR-15a-5p

表1 可能参与糖尿病肾病发生发展的miRNAs

作用	microRNAs
促进糖尿病肾病发展	miR-1207-5p、miR-124、miR-125b、miR-126、miR-133b、miR-135a、miR-141、miR-155、miR-181a/d、miR-184、miR-192、miR-199b、miR-let7b-5p 、miR-200b/c、miR-21、miR-214、miR-216a、miR-217、miR-22、miR-27a、miR-29c、miR-34a、miR-370、miR-377、miR-503、miR-770、miR-130b、miR-320c、miR-4490、miR-488、miR-101
抑制糖尿病肾病发展	miR-let7c-5p、miR-192、miR-1915-3p、miR-16、miR-146a、miR-130b、miR-126、miR-200a、miR-23b、miR-25、miR-26a、miR-29家族、miR-30家族、miR-33-5p、miR-346a、miR-374a、miR-424、miR-451、miR-4532、miR-93、miR-124、miR-342、miR-1228-3p、miR-27b-3p、miR-15a-5p

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