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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (10) : 790 -793. doi: 10.3877/cma.j.issn.1674-0785.2021.10.013

所属专题: 乳腺疾病

综述

人源性肿瘤异种移植模型在三阴性乳腺癌研究中的应用
郭俏丽1, 胡慧2,()   
  1. 1. 518036 深圳,北京大学深圳医院乳腺甲状腺外科;515041 汕头,汕头大学医学院
    2. 518036 深圳,北京大学深圳医院乳腺甲状腺外科
  • 收稿日期:2021-04-03 出版日期:2021-10-15
  • 通信作者: 胡慧

Application of patient-derived xenograft model in study of triple-negative breast cancer

Qiaoli Guo1, Hui Hu2,()   

  1. 1. Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shantou University Medical College, Shantou 515041, China
    2. Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2021-04-03 Published:2021-10-15
  • Corresponding author: Hui Hu
引用本文:

郭俏丽, 胡慧. 人源性肿瘤异种移植模型在三阴性乳腺癌研究中的应用[J/OL]. 中华临床医师杂志(电子版), 2021, 15(10): 790-793.

Qiaoli Guo, Hui Hu. Application of patient-derived xenograft model in study of triple-negative breast cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(10): 790-793.

三阴性乳腺癌是一种缺乏雌激素受体、孕激素受体和人表皮生长因子受体2表达的乳腺癌亚型,与其他类型乳腺癌相比,三阴性乳腺癌发病年龄更早、恶性程度更高、预后更差,一直是研究关注的重点。人源性异种移植模型是一种把来源于患者肿瘤组织或原代细胞移植入免疫缺陷小鼠内形成移植瘤的模型,能很好地保留原代肿瘤的生物学特性,它在肿瘤研究中的应用越来越多,特别是三阴性乳腺癌的研究。本文就人源性肿瘤异种移植模型在三阴性乳腺癌研究中的应用进行综述。

Triple-negative breast cancer is one of the subtypes of breast cancer, which exhibits a lack of the expression of estrogen receptor and progesterone receptor and the amplification of human epidermal growth factor receptor 2. Compared with other subtypes, triple-negative breast cancer has a younger onset age, higher degree of malignancy, and worse prognosis, which has always been the focus of clinical and research. Patient-derived xenograft model is established by engrafting tumor tissue or primary cells into immunodeficient mice, which faithfully retains the biological features of the primary tumor. It has been widely used in the study of triple-negative breast cancer. This review describes the application of patient-derived xenograft model in the study of triple-negative breast cancer.

图1 人源性异种移植(PDX)模型构建过程示意图
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