切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (12) : 1284 -1288. doi: 10.3877/cma.j.issn.1674-0785.2022.12.023

综述

肾结石与高血压关系的研究进展
靳潇潇1, 郑聪2, 何文强2,()   
  1. 1. 450046 郑州,河南中医药大学
    2. 450046 郑州,河南中医药大学;450003 郑州,河南中医药大学第一附属医院泌尿外科二区
  • 收稿日期:2021-09-08 出版日期:2022-12-15
  • 通信作者: 何文强
  • 基金资助:
    河南省重点研发与推广专项(科技攻关)(182102310059)

Progress in understanding of relationship between nephrostasis and hypertension

Xiaoxiao Jin1, Cong Zheng2, Wenqiang He2,()   

  1. 1. Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
    2. Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China; Department of Urology, The First Affiliated Hospital of Henan University of TCM, Zhengzhou 450003, China
  • Received:2021-09-08 Published:2022-12-15
  • Corresponding author: Wenqiang He
引用本文:

靳潇潇, 郑聪, 何文强. 肾结石与高血压关系的研究进展[J/OL]. 中华临床医师杂志(电子版), 2022, 16(12): 1284-1288.

Xiaoxiao Jin, Cong Zheng, Wenqiang He. Progress in understanding of relationship between nephrostasis and hypertension[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(12): 1284-1288.

肾结石可导致新发高血压的形成,并且可加速高血压的发展;而高血压又是肾结石的危险因素。两者发生发展存在共同途径以及一定的联系,因此本文从高尿钙、胰岛素抵抗、炎症和细胞因子以及氧化应激和手术等方面对两者可能存在的联系进行综述,以便为更好的预防疾病的发生发展和未来的研究提供一些可行的思路。

Kidney stones can lead to the development of new-onset hypertension and accelerate its progression; hypertension, in turn, is a risk factor for kidney stones. Since there are common pathways and certain links between the development of both, this paper reviews the possible links between the two in terms of high urinary calcium, insulin resistance, inflammation, and cytokines, as well as oxidative stress and surgery, in order to provide some feasible ideas for better prevention of these diseases and their future research.

图1 钙代谢紊乱
图2 胰岛素抵抗相关机制 注:CELA2A为胰弹性蛋白酶糜蛋白酶样弹性蛋白酶家族成员2;TNF-α为肿瘤坏死因子;MS为代谢综合症
图3 炎症、氧化应激等相关途径 注:RAAS为肾素-血管紧张素-醛固酮系统;ROS为活性氧;NLRP3为炎症小体;IL-18为白介素-18;OPN为骨桥蛋白;MCP-1为单核细胞趋化蛋白-1
1
Khan SR, Pearle MS, Robertson WG, et al. Kidney stones [J]. Nat Rev Dis Primers, 2016, 2: 16008.
2
Wiener SV, Ho SP, Stoller ML. Beginnings of nephrolithiasis: insights into the past, present and future of Randall's plaque formation research [J]. Curr Opin Nephrol Hypertens, 2018, 27(4): 236-242.
3
李永超, 李杨. 肾结石Randall斑块研究进展 [J]. 中南大学学报(医学版), 2020, 45(4): 435-439.
4
Zeng G, Mai Z, Xia S, et al. Prevalence of kidney stones in China: an ultrasonography based cross-sectional study [J]. BJU Int, 2017, 120(1): 109-116.
5
Romero V, Akpinar H, Assimos DG. Kidney stones: a global picture of prevalence, incidence, and associated risk factors [J]. Rev Urol, 2010, 12(2-3): e86-96.
6
Ping H, Lu N, Wang M, et al. New-onset metabolic risk factors and the incidence of kidney stones: a prospective cohort study [J]. BJU Int, 2019, 124(6): 1028-1033.
7
Kittanamongkolchai W, Mara KC, Mehta RA, et al. Risk of hypertension among first-time symptomatic kidney stone formers [J]. Clin J Am Soc Nephrol, 2017, 12(3): 476-482.
8
Shang W, Li Y, Ren Y, et al. Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies [J]. BMC Nephrol, 2017, 18(1):344.
9
Eisner BH, Porten SP, Bechis SK, et al. Hypertension is associated with increased urinary calcium excretion in patients with nephrolithiasis [J]. J Urol, 2010, 183(2): 576-579.
10
靳潇潇, 何文强. 含钙肾结石与骨密度之间关系的研究现状 [J]. 中国骨质疏松杂志, 2021, 27(2): 303-307.
11
Borghi L, Schianchi T, Meschi T, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria [J]. N Engl J Med, 2002, 346(2): 77-84.
12
Nouvenne A, Meschi T, Prati B, et al. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial [J]. Am J Clin Nutr, 2010, 91(3): 565-570.
13
Hartman C, Friedlander JI, Moreira DM, et al. Does hypertension impact 24-hour urine parameters in patients with nephrolithiasis? [J]. Urology, 2015, 85(3): 539-543.
14
Kohjimoto Y, Sasaki Y, Iguchi M, et al. Association of metabolic syndrome traits and severity of kidney stones: results from a nationwide survey on urolithiasis in Japan [J]. Am J Kidney Dis, 2013, 61(6): 923-929.
15
Liu YT, Yang PY, Yang YW, et al. The association of nephrolithiasis with metabolic syndrome and its components: a cross-sectional analysis [J]. Ther Clin Risk Manag, 2017, 13: 41-48.
16
Zafar U, Khaliq S, Ahmad HU, et al. Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links [J]. Hormones, 2018, 17(3): 299-313.
17
Brown A E, Walker M. Genetics of insulin resistance and the metabolic syndrome [J]. Curr Cardiol Rep, 2016, 18(8): 75.
18
Strohmaier WL, Wrobel BM, Schubert G. Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis [J]. Urol Res, 2012, 40(2): 171-175.
19
Evan AP, Worcester EM, Coe FL, et al. Mechanisms of human kidney stone formation [J]. Urolithiasis, 2015, 43 Suppl 1(0 1):19-32.
20
Esteghamat F, Broughton JS, Smith E, et al. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation [J]. Nat Genet, 2019, 51(8): 1233-1243.
21
Khan SR, Canales BK, Dominguez-Gutierrez PR. Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation [J]. Nat Rev Nephrol, 2021, 17(6): 417-433.
22
Yang H, Xie T, Li D, et al. Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway [J]. Mol Metab, 2019, 23: 24-36.
23
Schmidt-Arras D, Rose-John S. IL-6 pathway in the liver: from physiopathology to therapy [J]. J Hepatol, 2016, 64(6): 1403-1415.
24
Zhang X, Fan L, Wu J, et al. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization [J]. J Hepatol, 2019, 71(1): 163-174.
25
Org E, Blum Y, Kasela S, et al. Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort [J]. Genome Biol, 2017, 18(1): 70.
26
Ma MC, Chen YS, Huang HS. Erythrocyte oxidative stress in patients with calcium oxalate stones correlates with stone size and renal tubular damage [J]. Urology, 2014, 83(2): 510 e9-17.
27
Joshi S, Khan SR. Opportunities for future therapeutic interventions for hyperoxaluria: targeting oxidative stress [J]. Expert Opin Ther Targets, 2019, 23(5): 379-391.
28
叶涛, 叶章群. 炎症和氧化应激反应与肾结石形成的研究进展 [J]. 中华泌尿外科杂志, 2018, 39(9): 711-713.
29
Wang Y, Sun C, Li C, et al. Urinary MCP-1、HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines [J]. Urolithiasis, 2017, 45(2): 159-175.
30
Fukumoto J, Fukumoto I, Parthasarathy PT, et al. NLRP3 deletion protects from hyperoxia-induced acute lung injury [J]. Am J Physiol Cell Physiol, 2013, 305(2): C182-C189.
31
Mulay S R, Kulkarni O P, Rupanagudi K V, et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion [J]. J Clin Invest, 2013, 123(1): 236-246.
32
Umekawa T, Hatanaka Y, Kurita T, et al. Effect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys [J]. J Am Soc Nephrol, 2004, 15(3): 635-644.
33
Dominguez-Gutierrez PR, Kusmartsev S, Canales BK, et al. Calcium oxalate differentiates human monocytes into inflammatory M1 macrophages [J]. Front Immunol, 2018, 9: 1863.
34
Liu Q, Liu Y, Guan X, et al. Effect of M2 macrophages on injury and apoptosis of renal tubular epithelial cells induced by calcium oxalate crystals [J]. Kidney Blood Press Res, 2019, 44(4): 777-791.
35
Small H Y, Migliarino S, Czesnikiewicz-Guzik M, et al. Hypertension: focus on autoimmunity and oxidative stress [J]. Free Radic Biol Med, 2018, 125: 104-115.
36
Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? [J]. Am J Physiol Regul Integr Comp Physiol, 2005, 289(4): R913-R935.
37
Montezano AC, Dulak-Lis M, Tsiropoulou S, et al. Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies [J]. Can J Cardiol, 2015, 31(5): 631-641.
38
陈颖妹, 马建林. 同型半胱氨酸、氧化应激与高血压关系的研究进展 [J]. 中国循证心血管医学杂志, 2020, 12(7): 895-896.
39
Rudemiller NP, Crowley SD. Interactions between the immune and the renin-angiotensin systems in hypertension [J]. Hypertension, 2016, 68(2): 289-296.
40
Justin Rucker A, Crowley SD. The role of macrophages in hypertension and its complications [J]. Pflugers Arch, 2017, 469(3-4): 419-430.
41
Chien TM, Lu YM, Chou YH, et al. Percutaneous nephrolithotomy increases the risk of new-onset hypertension: a nationwide 6-year follow-up study [J]. Urology, 2016, 97: 61-65.
42
Lu YM, Chien TM, Chou YH, et al. Is extracorporeal shock wave lithotripsy really safe in long-term follow-up? a nationwide retrospective 6-year age-matched non-randomized study [J]. Urol Int, 2017, 98(4): 397-402.
43
Ng CF, Luke S, Yee CH, et al. Extracorporeal shockwave lithotripsy could lead to a prolonged increase in the renal fibrotic process of up to 2 years [J]. J Endourol, 2018, 32(3): 223-229.
44
Fankhauser CD, Kranzbühler B, Poyet C, et al. Long-term adverse effects of extracorporeal shock-wave lithotripsy for nephrolithiasis and ureterolithiasis: a systematic review [J]. Urology, 2015, 85(5): 991-1006.
45
Qin B, Wang Q, Lu Y, et al. Losartan ameliorates calcium oxalate-induced elevation of stone-related proteins in renal tubular cells by Inhibiting NADPH oxidase and oxidative stress [J]. Oxid Med Cell Longev, 2018: 1271864.
46
Zhu J, Wang Q, Li C, et al. Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate [J]. Free Radic Biol Med, 2019, 134: 9-22.
47
庞翀, 陈群娟. 缬沙坦联合富马酸比索洛尔对老年高血压心脏病患者相关生化指标、炎症因子及氧化应激水平的影响 [J]. 中国老年学杂志, 2021, 41(4): 673-676.
48
Alexander RT, Mcarthur E, Jandoc R, et al. Antihypertensive medications and the risk of kidney stones in older adults: a retrospective cohort study [J]. Hypertens Res, 2017, 40(9): 837-842.
[1] 李嘉兴, 孙乙文, 李文星. NLRP3炎性小体在急性胰腺炎中作用的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(04): 300-304.
[2] 石兵, 张智, 陈金海, 唐文. 基于电磁跟踪和手术导航系统的实时超声引导下两种经皮肾盏穿刺方法的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 572-578.
[3] 王铭池, 梁乐琦, 刘永达. 基于NHANES数据库分析血脂与肾结石之间的关系[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 485-490.
[4] 方道成, 唐春华, 胡媛媛. 肠道菌群对草酸钙肾结石形成的影响[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 509-513.
[5] 张斌, 孙代宇, 胡昕, 韩菲, 李久明, 李功雨, 吴伟力, 冯宝富, 彭国辉. 评分系统预测不同经验手术者输尿管软镜术后结石清除率准确性的比较研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 353-360.
[6] 莫淇舟, 柳建军, 叶木石, 黄兴端, 李健维, 李思宁, 黄健, 苏劲. 二期原通道经皮肾镜联合输尿管软镜治疗经皮肾镜术后残石[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 380-385.
[7] 张璇, 高杨, 房雅君, 姚艳玲. 保护性机械通气在肺癌胸腔镜肺段切除术中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 563-567.
[8] 程柏凯, 杨光. 高胰岛素-正葡萄糖钳夹技术评估慢性肾脏病患者胰岛素抵抗的研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 334-339.
[9] 杜霞, 马梦青, 曹长春. 造影剂诱导的急性肾损伤的发病机制及干预靶点研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 279-282.
[10] 李佳曦, 刘子源, 李学民. 二甲双胍对年龄相关性白内障影响的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 252-256.
[11] 李京, 牛博, 刘晓蓓, 魏新雪, 黄荣. circ-SESN2 沉默靶向调控miRNA-23a-5p/ULK1 在神经细胞氧化应激损伤中的作用机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 263-272.
[12] 冯铭, 孙洪涛. 动脉瘤性蛛网膜下腔出血的颅内压监测与管理[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(04): 248-253.
[13] 王倩, 李敏, 白璐, 王保兴, 李英. 结节病肾损害的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 397-401.
[14] 何玉花, 钟欢妹, 王文惠, 沈永棋, 刘映云, 顾国威, 陈丹娜. 不同表型多囊卵巢综合征患者代谢指标及肥胖相关指标对多囊卵巢综合征合并代谢综合征人群的诊断效能分析[J/OL]. 中华临床实验室管理电子杂志, 2024, 12(04): 212-220.
[15] 张杨杨, 项楚淇, 朱满生. 肌少性肥胖与非酒精性脂肪性肝病间的关系以及研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(04): 276-282.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?