切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (12) : 1280 -1283. doi: 10.3877/cma.j.issn.1674-0785.2022.12.022

综述

代谢组学生物标志物:子宫内膜异位症诊疗的新靶点
王宁1, 吴慢莉2, 杨东霞3,()   
  1. 1. 056001 河北邯郸,邯郸市第一医院中西医结合科
    2. 274002 山东菏泽,菏泽市中医医院妇科
    3. 150000 哈尔滨,黑龙江中医药大学附属第二医院妇二科
  • 收稿日期:2021-09-10 出版日期:2022-12-15
  • 通信作者: 杨东霞
  • 基金资助:
    国家自然科学基金项目(81574015); 黑龙江省自然科学基金项目(LH2020H087); 国医大师孙申田教授“经颅重复针刺法”调控p38-MAPK通路抑制EMs疼痛中枢敏化机制研究(GY2022-25); 黑龙江中医药大学研究生创新科研项目(2020yjscx047); 黑龙江省中医药管理局国医大师学术思想传承科研课题(GY2022-25)

Metabolome biomarkers: new targets for the diagnosis and treatment of endometriosis

Ning Wang1, Manli Wu2, Dongxia Yang3,()   

  1. 1. Department of Integrated Chinese and Western Medicine, Handan First Hospital,Handan City, Hebei Province, Handan 156001, China
    2. Department of Gynecology, Heze Hospital of Traditional Chinese Medicine, Heze 274002, China
    3. Second Department of Gynecology, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China
  • Received:2021-09-10 Published:2022-12-15
  • Corresponding author: Dongxia Yang
引用本文:

王宁, 吴慢莉, 杨东霞. 代谢组学生物标志物:子宫内膜异位症诊疗的新靶点[J/OL]. 中华临床医师杂志(电子版), 2022, 16(12): 1280-1283.

Ning Wang, Manli Wu, Dongxia Yang. Metabolome biomarkers: new targets for the diagnosis and treatment of endometriosis[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(12): 1280-1283.

子宫内膜异位症是临床常见妇科疾病之一,由于其临床症状出现较晚且缺乏特异性及敏感性,严重影响内异症的诊断及早期干预。近几年,代谢组学技术广泛用于内异症的研究,本文旨在总结近些年代谢组学技术在内异症中的研究进展,并归纳内异症患者的卵泡液、血清、尿液及内膜组织等方面的相关生物标志物,并对其代谢组学特征进行阐述。

Endometriosis is one of the most common gynecological diseases in clinical practice. Due to its late onset of clinical symptoms and lack of specificity and sensitivity, the diagnosis and early intervention of endometriosis are seriously affected.In recent years, metabonomics technology has been widely used in the study of endometriosis. This paper aims to summarize the research progress of metabonomics technology in endometriosis in recent years, and summarize the biomarkers related to follicular fluid, serum, urine and intimal tissue of endometriosis patients, and elaborate their metabonomics characteristics.

1
郎景和. 对子宫内膜异位症认识的历史、现状与发展 [J]. 中国实用妇科与产科杂志, 2020, 36(3): 193-196.
2
李鳌, 孙宏伟, 崔彦. 代谢组学应用与研究进展 [J]. 医学研究杂志, 2020, 49(1): 168-171.
3
朱嘉, 方祝元. 代谢组学与中医"证"的相关性 [J]. 现代中西医结合杂志, 2009, 18(8): 938-941.
4
郭荔. 子宫内膜异位症患者血清代谢组学分析 [D]. 大连: 大连医科大学, 2019.
5
宋景艳. 子宫内膜异位症肾虚血瘀证代谢物组初筛及其与卵母细胞质量之间的关系 [D].济南: 山东中医药大学, 2017.
6
Vouk K, Hevir N, Ribić-Pucelj M, et al. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis [J]. Hum Reprod, 2012, 27(10): 2955-2965.
7
Lee YH, Tan CW, Venkatratnam A, et al. Dysregulated sphingolipid metabolism in endometriosis [J]. J Clin Endocrinol Metab, 2014 Oct;99(10):E1913-21.
8
Karaer A, Tuncay G, Mumcu A, et al. Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization [J]. Syst Biol Reprod Med, 2019, 65(1): 39-47.
9
Ocal P, Ersoylu B, Cepni I, et al. The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques [J]. J Assist Reprod Genet, 2012, 29(4): 299-304.
10
Pocate-Cheriet K, Santulli P, Kateb F, et al. The follicular fluid metabolome differs according to the endometriosis phenotype [J]. Reprod Biomed Online, 2020, 41(6): 1023-1037.
11
Dutta M, Joshi M, Srivastava S, et al. A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis [J]. Mol Biosyst, 2012, 8(12): 3281-3287.
12
Karanjgaokar VC, Murphy DJ, Samra JS, et al. Malignant transformation of residual endometriosis after hysterectomy: a case series [J]. Fertil Steril, 2009, 92(6): 2037.e19-21.
13
Lin J, Zhang X, Chen Y. Mutagen sensitivity as a susceptibility marker for endometriosis [J]. Hum Reprod, 2003, 18(10): 2052-2057.
14
Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, et al. Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients [J]. Fertil Steril, 2016, 106(7): 1733-1741.
15
Jana SK, Dutta M, Joshi M, et al. 1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis [J]. Biomed Res Int, 2013, 2013: 329058.
16
Dutta M, Singh B, Joshi M, et al. Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis [J]. Sci Rep, 2018, 8(1): 6466.
17
Ghazi N, Arjmand M, Akbari Z, et al. (1)H NMR- based metabolomics approaches as non-invasive tools for diagnosis of endometriosis [J]. Int J Reprod Biomed, 2016, 14(1): 1-8.
18
Maignien C, Santulli P, Kateb F, et al. Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance [J]. Reprod Biomed Online, 2020, 41(4): 640-652.
19
Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, et al. Nuclear magnetic resonance metabolomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis [J]. Fertil Steril, 2015, 104(5): 1202-1209.
20
Vouk K, Ribič-Pucelj M, Adamski J, et al. Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients [J]. J Steroid Biochem Mol Biol, 2016, 159: 60-69.
21
Li J, Guan L, Zhang H, et al. Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages [J]. Reprod Biol Endocrinol, 2018, 16(1): 42.
22
Chen JQ, Russo J. Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells [J]. Biochim Biophys Acta, 2012, 1826(2): 370-384.
[1] 朱成美, 赵巧梅, 邓学东. 经阴道超声联合生理盐水灌注直肠子宫陷凹对腹膜型子宫内膜异位症的诊断价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(01): 32-36.
[2] 何梦媛, 胡鸿保, 谢庆云, 廖冬发, 王维. 股骨头坏死的代谢组学的相关研究进展[J/OL]. 中华关节外科杂志(电子版), 2024, 18(03): 379-382.
[3] 费一鸣, 刘卓, 张丽娟. 组学分析在早产分子机制中的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 504-510.
[4] 乔林. 子宫内膜异位症鉴别诊断病例分享[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(02): 248-.
[5] 魏丽坤, 张旭红, 罗营, 薛凤霞, 王颖梅, 宋学茹, 田丽娜, 张艳芳, 王艳霞, 田文艳. 卵巢子宫内膜异位囊肿发生恶变并发盆腔脓肿1例并文献复习[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(06): 696-702.
[6] 罗丹, 孔为民, 陈姝宁, 赵小玲, 谢云凯. 子宫内膜异位症患者在位及异位内膜上皮细胞-间充质转化相关生物标志物的变化[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 530-539.
[7] 王璐, 王宇, 曾俊, 陈伟, 江华. 机器学习与多组学结合推动精准营养的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2022, 17(06): 540-544.
[8] 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261.
[9] 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317.
[10] 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434.
[11] 陈娟, 邓静敏. 胸部子宫内膜异位综合征的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 96-100.
[12] 王丁然, 迟洪滨. 自身免疫甲状腺炎对子宫内膜异位症患者胚胎移植结局的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(06): 682-688.
[13] 兰素伟, 王春辉, 常丽凤, 王杏茶, 翟明晶, 李阳. 血清miRNA-10b和miRNA-34a在子宫内膜异位症患者中的表达及与术后复发关系研究[J/OL]. 中华临床医师杂志(电子版), 2022, 16(08): 759-763.
[14] 汪泉, 周英妹, 何颖. p27、cyclin-E在子宫内膜异位症中的表达及其临床意义[J/OL]. 中华临床医师杂志(电子版), 2022, 16(06): 546-552.
[15] 洪凡, 陈敦金, 傅洋, 梁新月, 吴毅, 王晓怡. 体外受精-胚胎移植妊娠合并前置胎盘临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 176-182.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?