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中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (12) : 1280 -1283. doi: 10.3877/cma.j.issn.1674-0785.2022.12.022

综述

代谢组学生物标志物:子宫内膜异位症诊疗的新靶点
王宁1, 吴慢莉2, 杨东霞3,()   
  1. 1. 056001 河北邯郸,邯郸市第一医院中西医结合科
    2. 274002 山东菏泽,菏泽市中医医院妇科
    3. 150000 哈尔滨,黑龙江中医药大学附属第二医院妇二科
  • 收稿日期:2021-09-10 出版日期:2022-12-15
  • 通信作者: 杨东霞
  • 基金资助:
    国家自然科学基金项目(81574015); 黑龙江省自然科学基金项目(LH2020H087); 国医大师孙申田教授“经颅重复针刺法”调控p38-MAPK通路抑制EMs疼痛中枢敏化机制研究(GY2022-25); 黑龙江中医药大学研究生创新科研项目(2020yjscx047); 黑龙江省中医药管理局国医大师学术思想传承科研课题(GY2022-25)

Metabolome biomarkers: new targets for the diagnosis and treatment of endometriosis

Ning Wang1, Manli Wu2, Dongxia Yang3,()   

  1. 1. Department of Integrated Chinese and Western Medicine, Handan First Hospital,Handan City, Hebei Province, Handan 156001, China
    2. Department of Gynecology, Heze Hospital of Traditional Chinese Medicine, Heze 274002, China
    3. Second Department of Gynecology, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China
  • Received:2021-09-10 Published:2022-12-15
  • Corresponding author: Dongxia Yang
引用本文:

王宁, 吴慢莉, 杨东霞. 代谢组学生物标志物:子宫内膜异位症诊疗的新靶点[J]. 中华临床医师杂志(电子版), 2022, 16(12): 1280-1283.

Ning Wang, Manli Wu, Dongxia Yang. Metabolome biomarkers: new targets for the diagnosis and treatment of endometriosis[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(12): 1280-1283.

子宫内膜异位症是临床常见妇科疾病之一,由于其临床症状出现较晚且缺乏特异性及敏感性,严重影响内异症的诊断及早期干预。近几年,代谢组学技术广泛用于内异症的研究,本文旨在总结近些年代谢组学技术在内异症中的研究进展,并归纳内异症患者的卵泡液、血清、尿液及内膜组织等方面的相关生物标志物,并对其代谢组学特征进行阐述。

Endometriosis is one of the most common gynecological diseases in clinical practice. Due to its late onset of clinical symptoms and lack of specificity and sensitivity, the diagnosis and early intervention of endometriosis are seriously affected.In recent years, metabonomics technology has been widely used in the study of endometriosis. This paper aims to summarize the research progress of metabonomics technology in endometriosis in recent years, and summarize the biomarkers related to follicular fluid, serum, urine and intimal tissue of endometriosis patients, and elaborate their metabonomics characteristics.

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