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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (10) : 1102 -1108. doi: 10.3877/cma.j.issn.1674-0785.2023.10.013

综述

外泌体环状RNA在肿瘤免疫和癌症免疫治疗中的作用
张可, 闫琳琳, 王鹏飞, 章秀林, 赵帆, 胡守奎()   
  1. 100144 北京,北京大学首钢医院检验科
  • 收稿日期:2023-02-16 出版日期:2023-10-15
  • 通信作者: 胡守奎
  • 基金资助:
    首颐医疗科技发展基金(SGYYQ202102)

Roles of exosomal circRNA in tumour immunity and cancer immunotherapy

Ke Zhang, Linlin Yan, Pengfei Wang, Xiulin Zhang, Fan Zhao, Shoukui Hu()   

  1. Department of Clinical Laboratory, Peking University Shougang Hospital, Beijing 100144, China
  • Received:2023-02-16 Published:2023-10-15
  • Corresponding author: Shoukui Hu
引用本文:

张可, 闫琳琳, 王鹏飞, 章秀林, 赵帆, 胡守奎. 外泌体环状RNA在肿瘤免疫和癌症免疫治疗中的作用[J/OL]. 中华临床医师杂志(电子版), 2023, 17(10): 1102-1108.

Ke Zhang, Linlin Yan, Pengfei Wang, Xiulin Zhang, Fan Zhao, Shoukui Hu. Roles of exosomal circRNA in tumour immunity and cancer immunotherapy[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(10): 1102-1108.

在癌症的发生发展中,肿瘤免疫起着至关重要的作用,免疫治疗已成为癌症治疗的里程碑。外泌体环状RNA具有成为无创性生物标志物的潜力,并且多项研究表明其参与肿瘤免疫和癌症免疫治疗耐药性。在这篇综述中,我们总结了外泌体环状RNA在调节肿瘤免疫、预测免疫治疗疗效方面的作用。外泌体环状RNA在癌症临床治疗中具有巨大前景。

Tumor immunity plays a significant role in the occurrence and development of cancer. Immunotherapy has become a milestone in cancer treatment. Exosomal circRNA have the potential to be noninvasive biomarkers. Several studies showed that exosomal circRNA involved in tumor immunity and cancer immunotherapy resistance. In this review, we summarized the role of exosomal circRNA in regulating tumor immunity and predicting immunotherapy efficacy. Exosomal circRNA has great prospects in the clinical treatment of cancer.

表1 外泌体环状RNA在肿瘤免疫中的作用
癌症种类 分泌体环状RNA 表达 来源 受体细胞 通路 免疫功能 参考文献
肺癌 circZNF451 (hsa-circ-0002638) Cancer cell Macrophages FXR1/ ELF4/IRF4 Macrophages polarization、Anti-PD1 therapy resistance [18]
circRNA-002178 Cancer cell T cell miR-34/PDL1/PD1 PDL1/PD1 expression [19]
circHIPK3 Cancer cell Macrophages PTK2 M2 macrophage polarization [20]
hsa_circ_0000190 Cancer cell T cell Soluble PD-L1 Immune evasion [21]
circUSP7 (hsa_circ_0005152) Cancer cell T cell miR-934/SHP2 Anti-PD1 therapy resistance [22]
circFARSA Cancer cell Macrophages PTEN/PI3K/AKT M2 macrophage polarization [16]
circSHKBP1 (hsa_circ_0000936) Cancer cell Macrophages PKM2 M2 polarization and macrophage recruitment [23]
胃癌 hsa_circ_0017252 Cancer cell Macrophages miR-17-5p Macrophage M2 polarization [25]
食管癌 Circ0048117 Cancer cell Macrophages miR-140/ TLR4 M2 Macrophage Polarization [26]
胆管癌 Circ_0020256 (hsa_Circ_0020256) Tumor-associated macrophages NA miR-432-5p/E2F3 NA [40]
circ-PTPN22(hsa_circ_0110529) Cancer cell T cell、Neutrophil、Macrophages NA T cell exhaustion and neutrophil extracellular traps [27]
circ-ADAMTS6(hsa_circ_0072688) Cancer cell T cell、Neutrophil、Macrophages NA T cell exhaustion and neutrophil extracellular traps
肝细胞癌 circGSE1(hsa_circ_0000722) Cancer cell Regulatory T cell miR-324-5p/TGFBR1/Smad3 Expansion of regulatory T cells [28]
circTMEM181(hsa_circ_0001663) Cancer cell Macrophages miR-488-3p/CD39 Anti-PD1 therapy resistance [29]
hsa_circ_0074854 Cancer cell Macrophages Human antigen R (HuR) Macrophage M2 Polarization [30]
circUHRF1(hsa_circ_0048677) Cancer cell NK cell miR-449c-5p/TIM-3 Impairment of IFN-γ and TNF-α secretion in NK cells、Anti-PD1 therapy resistance [31]
hsa_circ_0004658 RBPJ-overexpressed macrophages NA miR-499b-5p/JAM3 NA [43]
结直肠癌 hsa_circ_0050334 Cancer cell macrophages hsa_miR_182_5p/RGS2 Survival [32]
CircPACRGL Cancer cell Neutrophil miR-142-3p/miR-506-3p/TGF-β1 Differentiation of N1 to N2 neutrophils [33]
CircEIF3K Cancer-associated fibroblast NA miR-214/PD-L1 NA [46]
胰腺导管腺癌 Circ_0006790 Bone marrow mesenchymal stem cell T cells CBX7/S100A11 Killing effects of T cells [48]
肾细胞癌 circSAFB2 Cancer cell Macrophages miR-620/JAK1/STAT3 M2 Macrophage Polarization [34]
口腔鳞状细胞癌 hsa_circ_0069313 Cancer cell Regulatory T cell miR-325-3p/Foxp3 CD8+ T cell infiltration [35]
胶质瘤 circNEIL3(hsa_circ_0001460) Cancer cell Tumour associated macrophages IGF2BP3/YAP1 Macrophage infiltration [33]
circBTG2 RBPJ-overexpressed macrophages NA miR-25-3p/PTEN NA [44]
乳腺癌 circPSMA1 Cancer cell NA miR-637/Akt1/β-catenin(cyclin D1) Immunosuppression [36]
circ_0001142(hsa_circ_0001142) Cancer cell Macrophages miR-361-3p /PIK3CB M2 Macrophage Polarization [37]
卵巢癌 Circ0001068(hsa_circ_0001068) Cancer cell T cell miR-28-5P/PD1 T cell apoptosis, disintegration [38]
子宫内膜癌 hsa_circ_0001610 Tumor-associated macrophage NA miR-139-5p NA [41]
前列腺癌 circMID1(hsa_circ_0007718) Myeloid-derived suppressor cells NA miR-506-3p/MID1 NA [51]
图1 外泌体环状RNA的肿瘤免疫机制研究在不同癌种中的分布
图2 外泌体环状RNA在癌症抗PD1治疗耐药中的作用
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