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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (10) : 1109 -1112. doi: 10.3877/cma.j.issn.1674-0785.2023.10.014

综述

甘油三酯-葡萄糖指数与2型糖尿病微血管并发症相关性的研究进展
邬秋俊, 向茜()   
  1. 661000 云南个旧,昆明医科大学第五附属医院(红河州滇南中心医院)内分泌代谢科
  • 收稿日期:2023-08-25 出版日期:2023-10-15
  • 通信作者: 向茜
  • 基金资助:
    2020年云南省高层次人才培养万人计划“名医”专项(YNWR-MY-2020-008); 2018年云南省卫生健康委医学学科头人(内分泌学)培养计划项目(D-2018034); 2022年云南省内分泌与代谢性疾病临床医学中心(临床重点学科)分中心建设项目

Progress in the association between triglyceride-glucose index and microvascular complications in type 2 diabetes

Qiujun Wu, Qian Xiang()   

  1. Department of Endocrinology and Metabolism, Honghe Southern Yunnan Central Hospital, the Fifth Affiliated Hospital of Kunming Medical University, Gejiu city 661000, China
  • Received:2023-08-25 Published:2023-10-15
  • Corresponding author: Qian Xiang
引用本文:

邬秋俊, 向茜. 甘油三酯-葡萄糖指数与2型糖尿病微血管并发症相关性的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(10): 1109-1112.

Qiujun Wu, Qian Xiang. Progress in the association between triglyceride-glucose index and microvascular complications in type 2 diabetes[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(10): 1109-1112.

甘油三酯-葡萄糖指数(TyG)是评估胰岛素抵抗(IR)的新指标,反映糖脂毒性。血糖、甘油三酯(TG)、IR通过增强氧化应激、损伤血管、减弱血管舒张功能等机制导致糖尿病微血管病。TyG与糖尿病微血管并发症相关性不一致,大部分研究显示TyG与糖尿病周围神经病变(DPN)、糖尿病肾病(DKD)、糖尿病视网膜病变(DR)、糖尿病足(DF)及糖尿病足溃疡(DFU)患病风险呈正相关,部分研究显示TyG与上述并发症不相关或负相关。目前就TyG与2型糖尿病微血管并发症的机制、相关性做一综述,以期探究TyG在糖尿病微血管并发症中的作用,为防治微血管并发症提供危险因素。

Triglyceride-glucose index (TyG) is a new measure of assessing insulin resistance (IR), reflecting glycolipid toxicity. Blood glucose, triglyceride (TG), and IR lead to diabetic microangiopathy through mechanisms including enhancing oxidative stress, damaging blood vessels, and weakening vasodilatation. TyG and diabetic microvascular complications, most studies showed a positive association of TyG with diabetic peripheral neuropathy (DPN), diabetic kidneg disease (DKD), diabetic retinopathy (DR), diabetic foot (DF) and diabetic foot ulcer (DFU) risk, some studies showed that TyG is not related or negatively associated with the above complications. At present, the mechanism and correlation of TyG and the microvascular complications of type 2 diabetes are reviewed in order to explore the role of TyG in the diabetic microvascular complications and provide risk factors for the prevention and treatment of microvascular complications.

1
Sun H, Saeedi P, Karuranga S, et al. IDF diabetes Atlas:Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J]. Diabetes Res Clin Pract, 2021: 109119.
2
Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, et al. Diagnostic accuracy of the triglyceride and glucose index for insulin resistance: A systematic review [J]. Int J Endocrinol, 2020: 4678526.
3
Yao H, Sun Z, Yuan W, et al. Relationship between the triglyceride-glucose index and type 2 diabetic macroangiopathy: A single-center retrospective analysis [J]. Diabetes Metab Syndr Obes, 2022, 15: 3483-3497.
4
Vági OE, Svébis MM, Domján BA, et al. The association between distal symmetric polyneuropathy in diabetes with all-cause mortality - a meta-analysis [J]. Front Endocrinol (Lausanne), 2023, 14: 1079009.
5
田福璐. 血清甘油三酯葡萄糖乘积指数与2型糖尿病周围神经病变相关性研究 [D]. 昆明: 昆明医科大学, 2020.
6
张艺, 韩桂艳, 高志强. APOB/ APOA1比值与2型糖尿病周围神经病病变的相关性分析[J]. LUNZHU, 2020, 12: 76-77.
7
Srinivasan S, Singh P, Kulothungan V, et al. Relationship between triglyceride glucose index, retinopathy and nephropathy in Type 2 diabetes [J]. Endocrinol Diabetes Metab, 2020, 4(1): e00151.
8
Akbar M, Bhandari U, Habib A, et al. Potential association of triglyceride glucose index with cardiac autonomic neuropathy in type 2 diabetes mellitus patients [J]. J Korean Med Sci, 2017, 32(7): 1131-1138.
9
Wiggin TD, Sullivan KA, Pop-Busui R, et al. Elevated triglycerides correlate with progression of diabetic neuropathy [J]. Diabetes, 2009, 58(7): 1634-1640.
10
D'Onofrio L, Ferdousi M, Kalteniece A, et al. Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia [J]. J Clin Lipidol, 2022, 16(4): 463-471.
11
张俊清, 苏白海, 张捷, 等. 糖尿病肾脏疾病早期预测和诊断专家共识 [J]. 中国内科杂志, 2021, 60(6): 522-532.
12
Shang J, Yu D, Cai Y, et al. The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes [J]. Medicine (Baltimore), 2019, 98(46): e17995.
13
Lv L, Zhou Y, Chen X, et al; Chongqing Diabetes Registry Group. Relationship between the TyG index and diabetic kidney disease in patients with type-2 diabetes mellitus [J]. Diabetes Metab Syndr Obes, 2021, 14: 3299-3306.
14
Liu L, Xia R, Song X, et al. Association between the triglyceride-glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross-sectional study [J]. J Diabetes Investig, 2021, 12(14): 557-565.
15
Zhao S, Yu S, Chi C. Association between macro-and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals:the Northern Shanghai Study [J]. Cardiovasc Diabetol, 2019, 18(1): 95.
16
Okamura T, Hashimoto Y, Hamaguchi M, et al. Triglyceride-glucose index is a predictor of incident chronic kidney disease: a population-based longitudinal study [J]. Clin Exp Nephrol, 2019, 23(7): 948-955.
17
Yao L, Wang X, Zhong Y, et al. The triglyceride-glucose index is associated with diabetic retinopathy in Chinese patients with type 2 diabetes:A hospital-based, nested, case-control study [J]. Diabetes Metab Syndr Obes, 2021, 14: 1547-1555.
18
Neelam K, Aung KCY, Ang K, et al. Association of triglyceride glucose index with prevalence and incidence of diabetic retinopathy in a Singaporean population [J]. Clin Ophthalmol, 2023, 17: 445-454.
19
Chiu H, Tsai HJ, Huang JC, et al. Associations between triglyceride-glucose index and micro-and macro-angiopathies in type 2 diabetes mellitus [J]. Nutrients, 2020, 12(2): 328.
20
Zhou Y, Lu Q, Zhang M, et al. The U-Shape relationship between triglyceride-glucose index and the risk of diabetic retinopathy among the US population[J]. J Pers Med, 2023, 13(3): 495.
21
Li X, Li G, Cheng T, et al. Correction to: Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study [J]. Lipids Health Dis, 2021, 20(1): 8.
22
Pan Y, Zhong S, Zhou K, et al. Association between diabetes complications and the triglyceride-glucose index in hospitalized patients with type 2 diabetes [J]. J Diabetes Res, 2021, 2021: 8757996.
23
李航, 柳怡莹, 刘遥, 等. 三酰甘油葡萄糖乘积指数与糖尿病足溃疡的相关性 [J]. 中国老年学杂志, 2022, 7(42): 1575-1579.
24
Yilmaz M, Karaaslan M, Tonyali S, et al. Triglyceride-Glucose Index (TyG) is associated with erectile dysfunction: A cross-sectional study [J]. Andrology, 2021, 9(1): 238-244.
25
Contreras C, Sánchez A, Martínez P, et al. Impaired endothelin calcium signaling coupled to endothelin type B receptors in penile arteries from insulin-resistant obese Zucker rats [J]. J Sex Med, 2013, 10(9): 2141-2153.
26
Belladelli F, Boeri L, Pozzi E, et al. Triglycerides/Glucose index is associated with sperm parameters and sperm DNA fragmentation in primary infertile men: A cross-sectional study [J]. Metabolites, 2022, 12(2): 143.
27
Clyne AM. Endothelial response to glucose: dysfunction, metabolism, and transport [J]. Biochem Soc Trans, 2021, 49(1): 313-325.
28
赵玉青, 柴颖儒, 江莉, 等. 高糖环境对心血管系统的影响及尼可地尔在心血管疾病中的应用 [J]. 中华临床医师杂志(电子版), 2017, 11(21): 2373-2376.
29
Yang S, Hu L, Han R, et al. Neuropeptides, inflammation, biofilms, and diabetic foot ulcers [J]. Exp Clin Endocrinol Diabetes, 2022, 130(7): 439-446.
30
张彦敏, 董俊婵, 高冕, 等. 体检人群糖尿病视网膜病变筛查及危险因素分析 [J]. 解放军医药杂志, 2020, 32(2): 60-63.
31
袁涛, 赵建宁, 包倪荣. 游离脂肪酸与组织细胞损伤相关性的研究进展 [J]. 医学研究生学报, 2014, 27(9): 994-997.
32
高春林, 赵亚萍, 陈小慧, 等. 不同浓度葡萄糖和游离脂肪酸对大鼠骨骼肌细胞株L6细胞胰岛素敏感性和细胞内活性氧的影响 [J]. 中国糖尿病杂志, 2011, 19(3): 221-224.
33
Kahn MB, Yuldasheva NY, Cubbon RM, et al. Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration [J]. Diabetes, 2011, 60(4): 1295-1303.
34
刘真真, 刘金波, 刘传谦, 等. 2型糖尿病微血管病变患者血浆内脂素水平变化及意义 [J]. 山东医药, 2018, 58(14): 47-49.
35
Ugwoke CK, Cvetko E, Umek N. Skeletal muscle microvascular dysfunction in obesity-related insulin resistance: pathophysiological mechanisms and therapeutic perspectives [J]. Int J Mol Sci, 2022, 23(2): 847.
36
Lee SB, Kim MK, Kang S, et al. Triglyceride glucose index is superior to the homeostasis model assessment of insulin resistance for predicting nonalcoholic fatty liver disease in Korean adults [J]. Endocrinol Metab (Seoul), 2019, 34(2): 179-186.
37
Shi YY, Zheng R, Cai JJ, et al. The association between triglyceride glucose index and depression: data from NHANES 2005-2018 [J]. BMC Psychiatry, 2021, 21(1): 267.
38
Wei Y, Guo J. High triglyceride-glucose index is associated with poor prognosis in patients with acute pancreatitis [J]. Dig Dis Sci, 2023, 68(3): 978-987.
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