切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 7 -10. doi: 10.3877/cma.j.issn.1674-0785.2024.01.002

所属专题: 临床药学

临床研究

复方托吡卡胺不同给药方法对儿童瞳孔散大效果影响的临床研究
续旭1, 张连新1, 蒋晶晶1, 张诚玥1,()   
  1. 1. 100045 北京,首都医科大学附属北京儿童医院
  • 收稿日期:2023-10-18 出版日期:2024-01-15
  • 通信作者: 张诚玥
  • 基金资助:
    首都医科大学附属北京儿童医院院级护理课题(YHL202205)

Pupil-dilating effects of different administration methods of topicarbamide in children: a preliminary clinical study

Xu Xu1, Lianxin Zhang1, Jingjing Jiang1, Chengyue Zhang1,()   

  1. 1. Department of Ophthalmology, Beijing Children’s Hospital, Beijing 100045, China
  • Received:2023-10-18 Published:2024-01-15
  • Corresponding author: Chengyue Zhang
引用本文:

续旭, 张连新, 蒋晶晶, 张诚玥. 复方托吡卡胺不同给药方法对儿童瞳孔散大效果影响的临床研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 7-10.

Xu Xu, Lianxin Zhang, Jingjing Jiang, Chengyue Zhang. Pupil-dilating effects of different administration methods of topicarbamide in children: a preliminary clinical study[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(01): 7-10.

目的

研究复方托吡卡胺滴眼液不同给药方法对儿童瞳孔散大效果的影响。

方法

本研究为前瞻性随机对照研究。收集2022年5月~2022年12月在北京儿童医院眼科住院行全麻眼底检查的患儿共88人(168只眼)。随机分为试验组和对照组。对照组(按照药物使用说明)采用复方托吡卡胺滴眼液术前点眼,每3 min一次,共3次;试验组采用复方托吡卡胺滴眼液点眼,每5 min一次,共4次。分别测量散瞳前、点药结束后0 min及20 min的瞳孔直径大小。

结果

对照组与试验组患儿在年龄和性别上差异无统计学意义(P>0.05)。对照组散瞳前、滴药后0 min、20 min瞳孔直径分别为(3.88±0.52)mm、(4.81±0.77)mm和(6.12±0.90)mm。试验组散瞳前、滴药后0 min、20 min瞳孔直径分别为(3.78±0.38)mm、(6.14±1.00)mm、(7.58±1.01)mm。2组患者在滴药后0 min及20 min瞳孔直径大小存在显著统计学差异(P<0.05)。

结论

针对儿童应用复方托吡卡胺滴眼液散瞳,采用每5 min点一次,共4次的方法,散瞳效果更佳。

Objective

To investigate the pupil-dilating effects of different administration methods of compound topicarbamide eye drops in children.

Methods

This is a prospective randomized controlled study in which 88 patients (168 eyes) who received fundus examination under general anesthesia at the Department of Ophthalmology of Beijing Children's Hospital from May 2022 to December 2022 were included. These patients were divided randomly into either an experimental group or a control group. Compound topiramide was used for three times every three minutes before surgery in the control group. Compound topiramide was administered for four times every five minutes in the experimental group. The pupil diameters were measured before application of eye drop as well as 0 minute and 20 minutes after application.

Results

There was no significant differences in age or gender between the control group and the experimental group (P>0.05). The pupil diameters before application and 0 minute and 20 minutes after application in the control group were (3.88±0.52) mm, (4.81±0.77) mm, and (6.12±0.90) mm, respectively; the corresponding values in the experimental group were (3.78±0.38) mm, (6.14±1.00) mm, and (7.58±1.01) mm. There was a statistically significant difference in pupil diameter between the two groups at 0 min and 20 min after usage (P<0.05).

Conclusion

The new administration method of compound topicarbamide (four times once every five minutes) can achieve better effect on pupil size for children who need fundus examination.

图1 自制瞳孔测量尺
表1 2组患者基本情况的比较
表2 2组患者散瞳情况比较(
1
张自峰, 李曼红, 王雨生, 等. 西安地区出生体重2 kg以上早产儿视网膜病变分析[J]. 中华眼科杂志, 2014, 50(3): 184-188.
2
Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests forjoinpoint regression with applications to cancer rates[J]. Stat Med, 2000, 19(3): 335-351.
3
Solebo AL, Rahi J. Epidemiology, aetiology andmanagement of visual impairment in children[J]. Arch Dis Child, 2014, 99(4): 375-379.
4
Phillips CI. Dilate the pupil and see the fundus[J]. BMJ (Clin Res Ed), 1984, 288(6433): 1779-1780.
5
Whitmer L. To see or not to see: routine pupillary dilation[J]. J Am Optom Assoc, 1989, 60(7): 496-500.
6
Tan Colin S, Lim Louis W, et al. Journal of cataract and refractive surgery2019 01;45(1):113
7
褚仁远, 赵家良. 儿童青少年屈光不正诊治应以睫状肌麻痹下验光结果为基准[J] . 中华眼科杂志, 2019, 55(2): 86-88.
8
Lee VHL, Robinson JR. Topical ocular drug delivery: recent developments and future challenges[J]. J Ocul Pharmacol, 1986, 2(1): 67.
9
李清波.《儿童睫状肌麻痹验光及安全用药专家共识》(2019版)解读[J]. 中国眼镜科技杂志, 2020, (5): 102-105.
10
Delpero WT, Robinson BE, Gardiner JA, et al. Evidence-based clinical practice guidelines for the periodic eye examination in children aged 0-5 years in Canada[J]. Can J Ophthalmol, 2019, 54(6): 751-759.
11
Levine L. Tropicamide-induced mydriasis in densely pigmented eyes[J]. Am J Optom Physiol Opt, 1983, 60(8): 673-677.
12
Dillon JR, Tyhurst CW, Yolton RL. The mydriatic effect of tropicamide on light and dark irides[J]. J Am Optom Assoc, 1977, 48(5): 653-658.
13
Kubo DJ, Wing TW, Polse KA, et al. Mydriatic effects using low concentrations of phenylephrine hydrochloride[J]. J Am Optom Assoc, 1975, 46(8): 817-822.
[1] 陶宏宇, 叶菁菁, 俞劲, 杨秀珍, 钱晶晶, 徐彬, 徐玮泽, 舒强. 右心声学造影在儿童右向左分流相关疾病中的评估价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 959-965.
[2] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[3] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[4] 王雅楠, 刘丹, 曹正浓, 贾慧敏. 儿童迟发性先天性膈疝患儿的临床诊治特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 410-419.
[5] 陈桂华, 钟小玲, 谢雨, 王慧, 谢江, 杨涛毅. 合并肝脏疾病特殊健康状态儿童疫苗预防接种及时性临床分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 431-439.
[6] 刘静, 王燕妮, 王继萍. 儿童毛发移植应用前景及病例讨论[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 368-368.
[7] 郑宝英, 黄小兰, 贾楠, 朱春梅. 儿童难治性肺炎支原体肺炎早期预警指标[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 215-221.
[8] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[9] 丁荷蓓, 王珣, 陈为国. 七氟烷吸入麻醉与异丙酚静脉麻醉在儿童腹股沟斜疝手术中的应用比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 570-574.
[10] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[11] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[12] 张佳臣, 宋红欣. 儿童青少年等效球镜屈光度变化与屈光不正进展相关性的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 217-222.
[13] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[14] 陈晓胜, 何佳, 刘方, 吴蕊, 杨海涛, 樊晓寒. 直立倾斜试验诱发31 秒心脏停搏的植入心脏起搏器儿童一例并文献复习[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 488-494.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要