切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 83 -86. doi: 10.3877/cma.j.issn.1674-0785.2024.01.013

综述

肺肝样腺癌诊治研究进展
陈雪芬1, 韦虹羽1, 孙起翔1, 赵华1, 闫萍1, 龚臣1,()   
  1. 1. 530021 南宁,广西医科大学第一附属医院老年病学呼吸内科
  • 收稿日期:2023-09-23 出版日期:2024-01-15
  • 通信作者: 龚臣
  • 基金资助:
    广西壮族自治区卫生健康委员会自筹经费科研课题资助项目(Z20210089)

Progress in diagnosis and treatment of hepatoid adenocarcinoma of the lung

Xuefen Chen1, Hongyu Wei1, Qixiang Sun1, Hua Zhao1, Ping Yan1, Chen Gong1,()   

  1. 1. Geriatric Respiratory Medicine Department, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2023-09-23 Published:2024-01-15
  • Corresponding author: Chen Gong
引用本文:

陈雪芬, 韦虹羽, 孙起翔, 赵华, 闫萍, 龚臣. 肺肝样腺癌诊治研究进展[J]. 中华临床医师杂志(电子版), 2024, 18(01): 83-86.

Xuefen Chen, Hongyu Wei, Qixiang Sun, Hua Zhao, Ping Yan, Chen Gong. Progress in diagnosis and treatment of hepatoid adenocarcinoma of the lung[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(01): 83-86.

肺肝样腺癌(HAL)是一种罕见且具有侵袭性的肺癌病理亚型,其组织学特征类似于肝细胞癌,好发于老年男性,其发生可能与胚胎发育过程中原始潜能干细胞发育异常相关,诊断及鉴别诊断需依靠影像学等排除其他部位肝样腺癌并结合病灶形态学及免疫组化进行综合判断,血清AFP水平与疾病活动相关,但AFP与预后的关系仍有待更多数据支撑,HAL患者预后较非小细胞肺癌差,目前尚无统一治疗指南,多推荐参考肺腺癌方案,本文旨在就HAL的诊治进展进行综述,以增进对这种独特实体瘤的理解,以提高临床上对该病的诊治水平。

Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive pathological subtype of lung cancer. With histological characteristics resembling those of hepatocellular carcinoma, HAL predominantly affects elderly men. The development of HAL may be associated with abnormal development of primitive pluripotent stem cells during embryonic development. Its diagnosis and differential diagnosis rely on the exclusion of hepatoid adenocarcinoma in other locations through imaging studies, as well as comprehensive evaluation based on lesion morphology and immunohistochemistry. Serum alpha-fetoprotein (AFP) levels are associated with disease activity, but the relationship between AFP and prognosis requires more supporting data. HAL patients have a worse prognosis compared to non-small cell lung cancer patients, and there are currently no unified treatment guidelines. Treatment recommendations often refer to those for lung adenocarcinoma. This article aims to provide a comprehensive review of the progress in the diagnosis and treatment of HAL, in order to enhance understanding of this unique solid tumor and improve its clinical management.

1
Ishikura H, Fukasawa Y, Ogasawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report[J]. Cancer, 1985, 56(4): 840-848.
2
Metzgeroth G, Strobel P, Baumbusch T, et al. Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity[J]. Onkologie, 2010, 33(5): 263-269.
3
方三高, 陈真伟, 魏建国. 2021年第5 版WHO 胸部肿瘤分类[J]. 诊断病理学杂志, 2021, 28(7): 591-593.
4
Yang K, Jiang H, Li Q. Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature[J]. Medicine (Baltimore), 2019, 98(14): e15053.
5
Ishikura H, Kanda M, Ito M, et al. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma[J]. Virchows Arch A Pathol Anat Histopathol, 1990, 417(1): 73-80.
6
Saka H, Sakai S, Kondo N, et al. Successful resection of alpha-fetoprotein-producing lung cancer[J]. Chest, 1988, 94(4): 879-880.
7
Mendoza A, Voland J, Wolf P, et al. Supradiaphragmatic liver in the lung[J]. Arch Pathol Lab Med, 1986, 110(11): 1085-1086.
8
Xu K, Gao J, Feng L, et al. A case report of pulmonary hepatoid adenocarcinoma: promoting standardized diagnosis and treatment of the rare disease[J]. Front Immunol, 2023, 14: 1203876.
9
刘汉勇, 王晓玫, 成志强, 等. 肺原发性肝样腺癌临床病理观察[J/OL].中华临床医师杂志(电子版), 2014, 8(14): 2608-2612.
10
Mokrim M, Belbaraka R, Allaoui M ,et al. Hepatoid adenocarcinoma of the lung: A case report and literature review[J]. J Gastrointest Cancer, 2012, 43Suppl 1: S125-127.
11
Haninger DM, Kloecker GH, Bousamra Ii M, et al. Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature[J]. Mod Pathol, 2014, 27(4): 535-542.
12
Tonyali O, Gonullu O, Ozturk MA, et al. Hepatoid adenocarcinoma of the lung and the review of the literature[J]. J Oncol Pharm Pract, 2020, 26(6): 1505-1510.
13
Grossman K, Beasley MB, Braman SS. Hepatoid adenocarcinoma of the lung: review of a rare form of lung cancer[J]. Respir Med, 2016, 119: 175-179.
14
Pasricha S, Grover S, Kamboj M, et al. Hepatoid adenocarcinoma of lung: A diagnostic challenge-series of six cases with histopathological, predictive molecular and PD.L1 assessment[J]. Indian J Pathol Microbiol, 2021, 64(1): 128-131.
15
Wang W, Li G. Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis[J]. Transl Cancer Res, 2020, 9(9): 5401-5410.
16
Hou Z, Xie J, Zhang L, et al. Hepatoid adenocarcinoma of the lung: A systematic review of the literature from 1981 to 2020[J]. Front Oncol, 2021, 11: 702216.
17
Mao JX, Liu C, Zhao YY, et al. Merged hepatopulmonary features in hepatoid adenocarcinoma of the lung: a systematic review[J]. Am J Transl Res, 2021, 13(3): 898-922.
18
Augustin G, Jelincic Z, Tentor D, et al. Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers[J]. Acta Gastroenterol Belg, 2009, 72(2): 253-256.
19
Motooka Y, Yoshimoto K, Semba T, et al. Pulmonary hepatoid adenocarcinoma: report of a case[J]. Surg Case Rep, 2016, 2(1): 1.
20
Che YQ, Wang S, Luo Y, et al. Hepatoid adenocarcinoma of the lung: Presenting mediastinal metastasis without transfer to the liver[J]. Oncol Lett, 2014, 8(1): 105-110.
21
Xu SZ, Zhang XC, Jiang Q, et al. Alpha-fetoprotein-producing hepatoid adenocarcinoma of the lung responsive to sorafenib after multiline treatment: A case report[J]. World J Clin Cases, 2022, 10(28): 10236-10243.
22
Papatsimpas G, Kamposioras K, Goula K, et al. Hepatoid pancoast tumor. A case report and review of the literature[J]. Lung Cancer, 2012, 77(2): 239-245.
23
Li J, Qi H, Xu B, et al. Genomic profiles of a patient of pulmonary hepatoid adenocarcinoma with high AFP level: A case report[J]. Front Oncol, 2019, 9: 1360.
24
Sun JN, Zhang BL, Li LK, et al. Hepatoid adenocarcinoma of the lung without production of alpha-fetoprotein: A case report and review of the literature[J]. Oncol Lett, 2016, 12(1): 189-194.
25
张衎, 刘倩, 刘标, 等. 肺原发甲胎蛋白阳性肝样腺癌1例[J]. 中华结核和呼吸杂志, 2023, 46(7): 700-707.
26
Nagai E, Ueyama T, Yao T, et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis[J]. Cancer, 1993, 72(6): 1827-1835.
27
Wang S, Li M, Chen H, et al. FDG PET/CT in hepatoid adenocarcinoma of the lung[J]. Clin Nucl Med, 2016, 41(7): e340-341.
28
Yatabe Y, Dacic S, Borczuk AC, et al. Best practices recommendations for diagnostic immunohistochemistry in lung cancer[J]. J Thorac Oncol, 2019, 14(3): 377-407.
29
Zhang C, Zhang J, Xu FP, et al. Genomic landscape and immune microenvironment features of preinvasive and early invasive lung adenocarcinoma[J]. J Thorac Oncol, 2019, 14(11): 1912-1923.
30
Broers JL, Ramaekers FC, Rot MK, et al. Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies[J]. Cancer Res, 1988, 48(11): 3221-3229.
31
Rabban JT, Zaloudek CJ. A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord-stromal tumours[J]. Histopathology, 2013, 62(1): 71-88.
32
Mukhopadhyay S, Dermawan JK, Lanigan CP, et al. Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections[J]. Mod Pathol, 2019, 32(1): 100-109.
33
Chen L, Han X, Gao Y, et al. Anti-PD-1 therapy achieved disease control after multiline chemotherapy in unresectable KRAS-positive hepatoid lung adenocarcinoma: A case report and literature review[J]. Onco Targets Ther, 2020, 13: 4359-4364.
34
Lei L, Yang L, Xu YY ,et al. Hepatoid adenocarcinoma of the lung: An analysis of the Surveillance, Epidemiology, and End Results (SEER) database[J]. Open Med (Wars), 2021, 16(1): 169-174.
35
Wu Z, Upadhyaya M, Zhu H, et al. Hepatoid adenocarcinoma: computed tomographic imaging findings with histopathologic correlation in 6 cases[J]. J Comput Assist Tomogr, 2007, 31(6): 846-852.
36
Carlinfante G, Foschini MP, Pasquinelli G, et al. Hepatoid carcinoma of the lung: a case report with immunohistochemical, ultrastructural and in-situ hybridization findings[J]. Histopathology, 2000, 37(1): 88-89.
37
Hayashi Y, Takanashi Y, Ohsawa H, et al. Hepatoid adenocarcinoma in the lung[J]. Lung Cancer, 2002, 38(2): 211-214.
38
Gavrancic T, Park YH. A novel approach using sorafenib in alpha fetoprotein-producing hepatoid adenocarcinoma of the lung[J]. J Natl Compr Canc Netw, 2015, 13(4): 387-391; quiz 391.
39
Basse V, Schick U, Gueguen P, et al. A mismatch repair-deficient hepatoid adenocarcinoma of the lung responding to anti-PD-L1 durvalumab therapy despite no PD-L1 expression[J]. J Thorac Oncol, 2018, 13(7): e120-e122.
40
Chen HF, Wang WX, Li XL, et al. Hepatoid adenocarcinoma of the lung with EGFR mutation and the response to tyrosine kinase inhibitors[J]. J Thorac Oncol, 2019, 14(10): e217-e219.
41
Khozin S, Roth MJ, Rajan A, et al. Hepatoid carcinoma of the lung with anaplastic lymphoma kinase gene rearrangement[J]. J Thorac Oncol, 2012, 7(11): e29-31.
42
Inagawa S, Shimazaki J, Hori M, et al. Hepatoid adenocarcinoma of the stomach[J]. Gastric Cancer, 2001, 4(1): 43-52.
43
Kumashiro Y, Yao T, Aishima S, et al. Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype[J]. Hum Pathol, 2007, 38(6): 857-863.
44
Maitra A, Murakata LA, Albores-Saavedra J. Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid adenocarcinomas of the gastrointestinal tract[J]. Am J Clin Pathol, 2001, 115(5): 689-694.
[1] 林凌, 李佩, 赵玮. 牛牙样牙发病机制的研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(02): 75-80.
[2] 兰青, 熊枝繁, 杨盛力. 甲胎蛋白在胃肝样腺癌中的作用机制及诊断预后研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(05): 376-379.
[3] 王晓燕, 肖佑, 肖戈, 王真权. 老年结直肠癌肺转移CT特征及高危因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 506-509.
[4] 陈华萍, 陈晓龙, 胡明冬. 难治性哮喘的发病机制及诊治进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 144-147.
[5] 许厅, 熊智倩, 刘俪婷, 姜燕, 苏朝江, 刘宗旸. 维持性血液透析患者皮肤瘙痒症的发病机制及治疗研究进展[J]. 中华肾病研究电子杂志, 2023, 12(06): 334-338.
[6] 胡欣欣, 孟晓凡, 郭兆安. 高血压肾病的发病机制研究进展[J]. 中华肾病研究电子杂志, 2023, 12(06): 339-343.
[7] 唐凯, 刘正峰, 宋佳蔚, 卢秀珍. 角膜巩膜干凹斑的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 231-235.
[8] 李文捷, 卢弘. 幼年特发性关节炎相关葡萄膜炎的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(01): 40-44.
[9] 张坤淇, 张睿, 徐佳, 康庆林. 漂浮膝损伤的诊治进展[J]. 中华老年骨科与康复电子杂志, 2023, 09(04): 252-256.
[10] 金刚, 李英真, 施维, 李博. 帕金森病在病理生理学中的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 315-319.
[11] 尤亚茹, 刘译阳, 李莉明, 赵帅, 袁梦晨, 黄清博, 高剑波. 多层螺旋CT增强扫描对伴有肝转移的胃肝样腺癌的诊断价值[J]. 中华消化病与影像杂志(电子版), 2024, 14(01): 21-27.
[12] 李杨, 郭昆亮, 詹必成, 胡泉泉, 戴瑜珍. SMARCA4缺失性非小细胞肺癌临床病理特征、分子遗传学及程序性细胞死亡配体1表达分析[J]. 中华临床医师杂志(电子版), 2023, 17(12): 1309-1314.
[13] 徐军, 姬园园, 陈君平, 王健. 伴菊形团结构的脑膜瘤合并颅骨侵犯一例并文献复习[J]. 中华临床医师杂志(电子版), 2023, 17(08): 916-919.
[14] 陈雪芬, 邓静敏. 国内外179例原发性肺淋巴上皮瘤样癌的文献复习[J]. 中华临床医师杂志(电子版), 2023, 17(05): 551-556.
[15] 刘康蔚, 姚健凤. 老年慢性便秘患者的肠道菌群研究进展[J]. 中华老年病研究电子杂志, 2023, 10(04): 40-46.
阅读次数
全文


摘要