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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (07) : 682 -686. doi: 10.3877/cma.j.issn.1674-0785.2024.07.011

综述

细胞焦亡与疾病的关系研究进展
丁洪基1,(), 赵长江2, 孙鹏飞2, 王灿1, 王贵珍1, 李龙龙1   
  1. 1.257000 东营,山东大学齐鲁医院东营分院病理科
    2.257000 东营,山东大学齐鲁医院东营分院检验科
  • 收稿日期:2024-07-03 出版日期:2024-07-15
  • 通信作者: 丁洪基

Progress in understanding relationship between pyroptosis and diseases

Hongji Ding1,(), Changjiang Zhao2, Pengfei Sun2, Can Wang1, Guizhen Wang1, Longlong Li1   

  1. 1.Department of Pathology,Qilu Hospital of Shandong University Dongying Branch, Dongying 257000, China
    2.Clinical laboratory,Qilu Hospital of Shandong University Dongying Branch, Dongying 257000, China
  • Received:2024-07-03 Published:2024-07-15
  • Corresponding author: Hongji Ding
引用本文:

丁洪基, 赵长江, 孙鹏飞, 王灿, 王贵珍, 李龙龙. 细胞焦亡与疾病的关系研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 682-686.

Hongji Ding, Changjiang Zhao, Pengfei Sun, Can Wang, Guizhen Wang, Longlong Li. Progress in understanding relationship between pyroptosis and diseases[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(07): 682-686.

细胞焦亡(Pyroptosis)是近年来发现的一种炎性小体依赖性程序性细胞死亡形式,由半胱天冬酶(caspase)-1/4/5/11 和gasdermin 家族蛋白介导。许多研究表明,细胞焦亡是一把双刃剑,与疾病的发生和治疗密切相关。随着研究的不断深入,细胞焦亡与疾病的关系日益清晰,正在成为一个新的疾病研究热点。本文就细胞焦亡的病理学特征及其与相关疾病的关系进行综述,旨在为细胞焦亡的研究提供新的思路和方法。

Pyroptosis is a recently discovered form of inflammasome dependent programmed cell death mediated by caspase-1/4/5/11 and gasdermin family proteins. Many studies have shown that pyroptosis is a double-edged sword, which is closely related to the occurrence and treatment of diseases. With the deepening of research, the relationship between pyroptosis and disease is becoming more and more clear, and pyroptosis is becoming a new hot topic in disease research. In this paper, we review the pathological features of pyroptosis and its relationship with related diseases, in order to provide new ideas and methods for the study of pyroptosis.

1
Liu Z, Wang C, Lin C. Pyroptosis as a double-edged sword: the pathogenic and therapeutic roles in inflammatory diseases and cancers[J]. Life Sci, 2023, 318: 121498.
2
Wei Y, Yang L, Pandeya A, et al. Pyroptosis-induced inflammation and tissue damage [J]. J Mol Biol, 2022, 434(4): 167301.
3
Rao Z, Zhu Y, Yang P, et al. Pyroptosis in inflammatory diseases and cancer [J]. Theranostics, 2022, 12(9): 4310-4329.
4
Xu P, Li F, Tang H. Pyroptosis and airway homeostasis regulation [J].Physiol Res, 2023 , 72(1): 1-13.
5
Liu SW, Song WJ, Ma GK, et al. Pyroptosis and its role in cancer [J].World J Clin Cases, 2023, 11(11): 2386-2395.
6
Hou J, Li T, Hsu JM, et al. Gasdermins and cancers [J]. Semin Immunol, 2023, 70: 101833.
7
杨羽依, 刘秀萍. Gasdermin E 诱导细胞焦亡的研究 [J]. 中华病理学杂志, 2021, 50(4): 421-424.
8
Li Y, Jiang Q. Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling [J]. Front Immunol, 2023, 14: 1128358.
9
Huang E, Wang X, Chen L. Regulated cell death in endometriosis [J].Biomolecules, 2024, 14(2): 142.
10
Huang H, Weng Y, Tian W, et al. Molecular mechanisms of pyroptosis and its role in anti-tumor immunity [J]. Int J Biol Sci, 2023 , 19(13):4166-4180.
11
Cao Q, Zhang JB, Sun DY, et al. Pyroptosis, metabolism, and oxidation in tumorigenesis: mechanisms and therapeutic implications[J]. Antioxid Redox Signal, 2023, 39(7-9): 512-530.
12
Coll RC, Schroder K, Pelegrín P. NLRP3 and pyroptosis blockers for treating inflammatory diseases [J]. Trends Pharmacol Sci, 2022, 43(8):653-668.
13
Huang C, Li J, Zhang C. What role does pyroptosis play in cancer [J]?Mol Metab, 2022, 65: 101587.
14
Li F, Du R, Kou J, et al. Elucidating the role of pyroptosis in papillary thyroid cancer: prognostic, immunological, and therapeutic perspectives [J]. Cancer Cell Int, 2024, 24(1): 45
15
Mamun AA, Mimi AA, Aziz MA, et al. Role of pyroptosis in cancer and its therapeutic regulation [J]. Eur J Pharmacol, 2021, 910: 174444.
16
Khan M, Ai M, Du K, et al. Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective[J].Front Immunol, 2022, 13: 1062225.
17
Cao Z, Huang D, Tang C,et al. Pyroptosis in diabetes and diabetic nephropathy [J]. Clin Chim Acta, 2022, 531: 188-196.
18
Mu X, Wu X, He W, et al. Pyroptosis and inflammasomes in diabetic wound healing[J]. Front Endocrinol(Lausanne), 2022, 13: 950798.
19
Mamun AA, Wu Y, Nasrin F, et al. Role of pyroptosis in diabetes and its therapeutic implications [J]. J Inflamm Res, 2021, 14: 2187-2206.
20
Guo Q, Zhou C, Xiang Y, et al. Pyroptosis orchestrates immune responses in endometriosis [J]. Int Immunopharmacol, 2023, 118:110141.
21
Huang Y, Li X, Luo G, et al. Pyroptosis as a candidate therapeutic target for Alzheimer's disease [J]. Front Aging Neurosci, 2022, 14:996646.
22
Zhou J, Qiu J, SongY, et al. Pyroptosis and degenerative diseases of the elderly [J]. Cell Death Dis, 2023, 14(2): 94.
23
Rajesh Y, Kanneganti TD. Innate immune cell death in neuroinflammation and Alzheimer's disease [J]. Cells, 2022, 11(12):1885.
24
Lee S, Cho HJ, Ryu JH. Innate immunity and cell death in Alzheimer's disease [J]. ASN Neuro, 2021, 13: 17590914211051908.
25
Moonen S, Koper MJ, Schoor EV, et al. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons [J]. Acta Neuropathol, 2023, 145(2): 175-195.
26
Wang T, Long Q, Hu Y, et al. miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer’s disease [J]. Behav Brain Res,2023, 447: 114387.
27
Yang X, Wu Y, Zhang M, et al. Piceatannol protects against age-related hearing loss by inhibiting cellular pyroptosis and inflammation through regulated caspase11-GSDMD pathway [J]. Biomed Pharmacother,2023, 163: 114704.
28
Qu S, Lin H, Pfeiffer N, et al. Age-related macular degeneration and mitochondria-associated autoantibodies: a review of the specific pathogenesis and therapeutic strategies [J]. Int J Mol Sci, 2024, 25(3):1624.
29
Strzalka-Mrozik B, Madej M, Kurowska N, et al. Changes in the expression profile of pyroptosis-related genes in senescent retinal pigment epithelial cells after lutein treatment [J]. Curr Issues Mol Biol,2023, 45(2): 1500-1518.
30
Chen Y, Zeng D, Wei G, et al. Pyroptosis in osteoarthritis: molecular mechanisms and therapeutic implications [J]. J Inflamm Res, 2024,17: 791-803.
31
Imre G. Pyroptosis in health and disease [J]. Am J Physiol Cell Physiol, 2024, 326(3): C784-C794.
32
Zhou LY, Yin XC. Research progress of pyroptosis in leukemia: from mechanism to treatment -review [J]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2024, 32(1): 287-291.
33
Newton K, Strasser A, Kayagaki N, et al. Cell death [J]. Cell, 2024,187(2): 235-256.
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