切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (07) : 682 -686. doi: 10.3877/cma.j.issn.1674-0785.2024.07.011

综述

细胞焦亡与疾病的关系研究进展
丁洪基1,(), 赵长江2, 孙鹏飞2, 王灿1, 王贵珍1, 李龙龙1   
  1. 1.257000 东营,山东大学齐鲁医院东营分院病理科
    2.257000 东营,山东大学齐鲁医院东营分院检验科
  • 收稿日期:2024-07-03 出版日期:2024-07-15
  • 通信作者: 丁洪基

Progress in understanding relationship between pyroptosis and diseases

Hongji Ding1,(), Changjiang Zhao2, Pengfei Sun2, Can Wang1, Guizhen Wang1, Longlong Li1   

  1. 1.Department of Pathology,Qilu Hospital of Shandong University Dongying Branch, Dongying 257000, China
    2.Clinical laboratory,Qilu Hospital of Shandong University Dongying Branch, Dongying 257000, China
  • Received:2024-07-03 Published:2024-07-15
  • Corresponding author: Hongji Ding
引用本文:

丁洪基, 赵长江, 孙鹏飞, 王灿, 王贵珍, 李龙龙. 细胞焦亡与疾病的关系研究进展[J]. 中华临床医师杂志(电子版), 2024, 18(07): 682-686.

Hongji Ding, Changjiang Zhao, Pengfei Sun, Can Wang, Guizhen Wang, Longlong Li. Progress in understanding relationship between pyroptosis and diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(07): 682-686.

细胞焦亡(Pyroptosis)是近年来发现的一种炎性小体依赖性程序性细胞死亡形式,由半胱天冬酶(caspase)-1/4/5/11 和gasdermin 家族蛋白介导。许多研究表明,细胞焦亡是一把双刃剑,与疾病的发生和治疗密切相关。随着研究的不断深入,细胞焦亡与疾病的关系日益清晰,正在成为一个新的疾病研究热点。本文就细胞焦亡的病理学特征及其与相关疾病的关系进行综述,旨在为细胞焦亡的研究提供新的思路和方法。

Pyroptosis is a recently discovered form of inflammasome dependent programmed cell death mediated by caspase-1/4/5/11 and gasdermin family proteins. Many studies have shown that pyroptosis is a double-edged sword, which is closely related to the occurrence and treatment of diseases. With the deepening of research, the relationship between pyroptosis and disease is becoming more and more clear, and pyroptosis is becoming a new hot topic in disease research. In this paper, we review the pathological features of pyroptosis and its relationship with related diseases, in order to provide new ideas and methods for the study of pyroptosis.

1
Liu Z, Wang C, Lin C. Pyroptosis as a double-edged sword: the pathogenic and therapeutic roles in inflammatory diseases and cancers[J]. Life Sci, 2023, 318: 121498.
2
Wei Y, Yang L, Pandeya A, et al. Pyroptosis-induced inflammation and tissue damage [J]. J Mol Biol, 2022, 434(4): 167301.
3
Rao Z, Zhu Y, Yang P, et al. Pyroptosis in inflammatory diseases and cancer [J]. Theranostics, 2022, 12(9): 4310-4329.
4
Xu P, Li F, Tang H. Pyroptosis and airway homeostasis regulation [J].Physiol Res, 2023 , 72(1): 1-13.
5
Liu SW, Song WJ, Ma GK, et al. Pyroptosis and its role in cancer [J].World J Clin Cases, 2023, 11(11): 2386-2395.
6
Hou J, Li T, Hsu JM, et al. Gasdermins and cancers [J]. Semin Immunol, 2023, 70: 101833.
7
杨羽依, 刘秀萍. Gasdermin E 诱导细胞焦亡的研究 [J]. 中华病理学杂志, 2021, 50(4): 421-424.
8
Li Y, Jiang Q. Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling [J]. Front Immunol, 2023, 14: 1128358.
9
Huang E, Wang X, Chen L. Regulated cell death in endometriosis [J].Biomolecules, 2024, 14(2): 142.
10
Huang H, Weng Y, Tian W, et al. Molecular mechanisms of pyroptosis and its role in anti-tumor immunity [J]. Int J Biol Sci, 2023 , 19(13):4166-4180.
11
Cao Q, Zhang JB, Sun DY, et al. Pyroptosis, metabolism, and oxidation in tumorigenesis: mechanisms and therapeutic implications[J]. Antioxid Redox Signal, 2023, 39(7-9): 512-530.
12
Coll RC, Schroder K, Pelegrín P. NLRP3 and pyroptosis blockers for treating inflammatory diseases [J]. Trends Pharmacol Sci, 2022, 43(8):653-668.
13
Huang C, Li J, Zhang C. What role does pyroptosis play in cancer [J]?Mol Metab, 2022, 65: 101587.
14
Li F, Du R, Kou J, et al. Elucidating the role of pyroptosis in papillary thyroid cancer: prognostic, immunological, and therapeutic perspectives [J]. Cancer Cell Int, 2024, 24(1): 45
15
Mamun AA, Mimi AA, Aziz MA, et al. Role of pyroptosis in cancer and its therapeutic regulation [J]. Eur J Pharmacol, 2021, 910: 174444.
16
Khan M, Ai M, Du K, et al. Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective[J].Front Immunol, 2022, 13: 1062225.
17
Cao Z, Huang D, Tang C,et al. Pyroptosis in diabetes and diabetic nephropathy [J]. Clin Chim Acta, 2022, 531: 188-196.
18
Mu X, Wu X, He W, et al. Pyroptosis and inflammasomes in diabetic wound healing[J]. Front Endocrinol(Lausanne), 2022, 13: 950798.
19
Mamun AA, Wu Y, Nasrin F, et al. Role of pyroptosis in diabetes and its therapeutic implications [J]. J Inflamm Res, 2021, 14: 2187-2206.
20
Guo Q, Zhou C, Xiang Y, et al. Pyroptosis orchestrates immune responses in endometriosis [J]. Int Immunopharmacol, 2023, 118:110141.
21
Huang Y, Li X, Luo G, et al. Pyroptosis as a candidate therapeutic target for Alzheimer's disease [J]. Front Aging Neurosci, 2022, 14:996646.
22
Zhou J, Qiu J, SongY, et al. Pyroptosis and degenerative diseases of the elderly [J]. Cell Death Dis, 2023, 14(2): 94.
23
Rajesh Y, Kanneganti TD. Innate immune cell death in neuroinflammation and Alzheimer's disease [J]. Cells, 2022, 11(12):1885.
24
Lee S, Cho HJ, Ryu JH. Innate immunity and cell death in Alzheimer's disease [J]. ASN Neuro, 2021, 13: 17590914211051908.
25
Moonen S, Koper MJ, Schoor EV, et al. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons [J]. Acta Neuropathol, 2023, 145(2): 175-195.
26
Wang T, Long Q, Hu Y, et al. miR-181c-5p suppresses neuronal pyroptosis via NLRP1 in Alzheimer’s disease [J]. Behav Brain Res,2023, 447: 114387.
27
Yang X, Wu Y, Zhang M, et al. Piceatannol protects against age-related hearing loss by inhibiting cellular pyroptosis and inflammation through regulated caspase11-GSDMD pathway [J]. Biomed Pharmacother,2023, 163: 114704.
28
Qu S, Lin H, Pfeiffer N, et al. Age-related macular degeneration and mitochondria-associated autoantibodies: a review of the specific pathogenesis and therapeutic strategies [J]. Int J Mol Sci, 2024, 25(3):1624.
29
Strzalka-Mrozik B, Madej M, Kurowska N, et al. Changes in the expression profile of pyroptosis-related genes in senescent retinal pigment epithelial cells after lutein treatment [J]. Curr Issues Mol Biol,2023, 45(2): 1500-1518.
30
Chen Y, Zeng D, Wei G, et al. Pyroptosis in osteoarthritis: molecular mechanisms and therapeutic implications [J]. J Inflamm Res, 2024,17: 791-803.
31
Imre G. Pyroptosis in health and disease [J]. Am J Physiol Cell Physiol, 2024, 326(3): C784-C794.
32
Zhou LY, Yin XC. Research progress of pyroptosis in leukemia: from mechanism to treatment -review [J]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2024, 32(1): 287-291.
33
Newton K, Strasser A, Kayagaki N, et al. Cell death [J]. Cell, 2024,187(2): 235-256.
[1] 郝玥萦, 毛盈譞, 张羽, 汪佳旭, 韩林霖, 匡雯雯, 孟瑶, 杨秀华. 超声引导衰减参数成像评估肝脂肪变性及其对心血管疾病风险的预测价值[J]. 中华医学超声杂志(电子版), 2024, 21(08): 770-777.
[2] 曹雯佳, 刘学兵, 罗安果, 钟释敏, 邓岚, 王玉琳, 李赵欢. 超声矢量血流成像对2型糖尿病患者颈动脉壁剪切应力的研究[J]. 中华医学超声杂志(电子版), 2024, 21(07): 709-717.
[3] 姜珊, 李湘燕, 田硕涵, 温冰, 何睿, 齐心. 采用优化抗感染治疗模式改善糖尿病足感染预后的临床观察[J]. 中华损伤与修复杂志(电子版), 2024, 19(05): 398-403.
[4] 李楠, 邱思齐, 薛鸣宇, 张英. 自伤性口腔损害及其疾病管理[J]. 中华口腔医学研究杂志(电子版), 2024, 18(05): 307-311.
[5] 张静, 刘畅, 华成舸. 妊娠期患者口腔诊疗进展[J]. 中华口腔医学研究杂志(电子版), 2024, 18(05): 340-344.
[6] 韩婧, 郝少龙, 康骅. 北京市单中心甲状腺癌患者临床特征的回顾分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(05): 490-493.
[7] 张瑜, 姜梦妮. 基于DWI信号值构建局部进展期胰腺癌放化疗生存获益预测模型[J]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 657-664.
[8] 王哲学, 白峻阁, 姜得地, 李月刚, 杨明, 陈海鹏, 刘正. 局部进展期直肠癌经新辅助放化疗后肿瘤退缩分级及预后的影响因素分析[J]. 中华结直肠疾病电子杂志, 2024, 13(05): 368-374.
[9] 冯熔熔, 苏晓乐, 王利华. 慢性肾脏病患者并发心血管疾病相关生物标志物研究进展[J]. 中华肾病研究电子杂志, 2024, 13(05): 273-278.
[10] 崔文鹏. 腹膜透析在老年终末期肾脏疾病患者中的应用[J]. 中华肾病研究电子杂志, 2024, 13(05): 300-300.
[11] 闫维, 张二明, 张克, 安欣华, 向平超. 北京市石景山区40岁及以上居民早期慢性阻塞性肺疾病异质性及影响因素分析[J]. 中华临床医师杂志(电子版), 2024, 18(06): 533-540.
[12] 胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
[13] 张克, 杨占奇, 闫维, 张二明, 向平超. 持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者发生心脑血管事件的影响[J]. 中华临床医师杂志(电子版), 2024, 18(05): 433-440.
[14] 黄宏山, 陈成彩. 经淋巴管超声造影在乳腺癌前哨淋巴结诊断中的研究进展[J]. 中华临床医师杂志(电子版), 2024, 18(04): 411-414.
[15] 朱元州. 蜱及蜱传疾病[J]. 中华卫生应急电子杂志, 2024, 10(04): 256-256.
阅读次数
全文


摘要