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中华临床医师杂志(电子版) ›› 2026, Vol. 20 ›› Issue (05) : 381 -385. doi: 10.3877/cma.j.issn.1674-0785.2026.05.006

综述

卵圆孔未闭与老年隐源性卒中的相关性及治疗的研究进展
柴鑫茹, 张小杉, 刘笑笑, 姜莹, 赵捷, 施依璐, 张丹, 段莎莎()   
  1. 010050 呼和浩特,内蒙古医科大学附属医院超声科
  • 收稿日期:2026-05-13 出版日期:2026-05-30
  • 通信作者: 段莎莎
  • 基金资助:
    内蒙古医科大学面上项目(YKD2023MS013); 内蒙古自治区卫生健康委科技计划项目(202201247); 内蒙古自治区自然科学基金项目(2019MS08148); 内蒙古自治区自然科学基金项目(2022MS08050)

Patent foramen ovale and cryptogenic stroke in the elderly: advances in understanding their relevance and treatment

Xinru Chai, Xiaoshan Zhang, Xiaoxiao Liu, Ying Jiang, Jie Zhao, Yilu Shi, Dan Zhang, Shasha Duan()   

  1. Department of Ultrasound, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
  • Received:2026-05-13 Published:2026-05-30
  • Corresponding author: Shasha Duan
引用本文:

柴鑫茹, 张小杉, 刘笑笑, 姜莹, 赵捷, 施依璐, 张丹, 段莎莎. 卵圆孔未闭与老年隐源性卒中的相关性及治疗的研究进展[J/OL]. 中华临床医师杂志(电子版), 2026, 20(05): 381-385.

Xinru Chai, Xiaoshan Zhang, Xiaoxiao Liu, Ying Jiang, Jie Zhao, Yilu Shi, Dan Zhang, Shasha Duan. Patent foramen ovale and cryptogenic stroke in the elderly: advances in understanding their relevance and treatment[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2026, 20(05): 381-385.

卵圆孔未闭(PFO)是指3岁时心脏卵圆孔仍未完成解剖学闭合。研究表明,PFO与老年隐源性卒中(CS)的发生和预后密切相关。本文综述了老年CS合并PFO的流行病学、致病机制、相关性、治疗方法以及相关指南的最新研究,以期为临床医师提供诊断思路以及早期干预手段。

Patent foramen ovale is defined as the failure of the foramen ovale to achieve complete anatomical closure by three years of age. Numerous studies have demonstrated a close association between PFO and the occurrence and prognosis of cryptogenic stroke (CS) in the elderly. This article reviews the epidemiology, pathogenesis, associations, and treatment strategies for elderly CS patients with PFO, along with the latest updates from relevant guidelines, aiming to provide clinicians with diagnostic insights and early intervention strategies.

表1 老年患者PFO封堵术的现行指南建议
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