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中华临床医师杂志(电子版) ›› 2017, Vol. 11 ›› Issue (18) : 2241 -2244. doi: 10.3877/cma.j.issn.1674-0785.2017.18.007

所属专题: 文献

综述

妊娠期视神经脊髓炎谱系疾病的研究进展
石冰心1, 赵忙所2, 乔立艳2, 耿同超2,()   
  1. 1. 100084 北京,清华大学医学中心
    2. 100040 北京,清华大学附属玉泉医院神经内科
  • 收稿日期:2016-10-31 出版日期:2017-09-15
  • 通信作者: 耿同超
  • 基金资助:
    北京市自然科学基金资助项目(7164268)

Progress in research of neuromyelitis optica spectrum disorders in pregnancy

Bingxin Shi1, Mangsuo Zhao2, Liya Qiao2, Tongchao Geng2,()   

  1. 1. Medical Center, Tsinghua University, Beijing 100084, China
    2. Department of Neurology, Yuquan Hospital, Tsinghua University , Beijing 100040, China
  • Received:2016-10-31 Published:2017-09-15
  • Corresponding author: Tongchao Geng
  • About author:
    Corresponding author: Geng Tongchao, Email:
引用本文:

石冰心, 赵忙所, 乔立艳, 耿同超. 妊娠期视神经脊髓炎谱系疾病的研究进展[J/OL]. 中华临床医师杂志(电子版), 2017, 11(18): 2241-2244.

Bingxin Shi, Mangsuo Zhao, Liya Qiao, Tongchao Geng. Progress in research of neuromyelitis optica spectrum disorders in pregnancy[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(18): 2241-2244.

视神经脊髓炎谱系疾病(neuromyelitisopticaspectrum disorder,NMOSD)是一种以体液免疫为主要机制的中枢神经系统脱髓鞘疾病,多见于育龄期女性。妊娠被认为是NMOSD复发的可能危险因素,很多女性患者因为顾虑疾病的复发加重而被建议禁止妊娠。随着临床工作的积累和对该病研究的不断进展,我们发现,NMOSD患者在使用激素和/或免疫抑制药物下可以安全妊娠,并将对胎儿的的损害控制到最低水平。疾病活动期采取避孕措施,病情稳定半年后再受孕,妊娠期及产后维持预防复发的修饰治疗可能是合理的。

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disorder of the central nervous system characterized by recurrent optic neuritis and longitudinal extensive transverse myelitis. It frequently occurs in childbearing-age women. Pregnancy is regarded as a possible independent risk factor for disease relapse. Many female patients were advised not to be pregnant, given concerns about disease exacerbation. With the accumulation of clinical experience and the progress in research of this disease, we found that NMOSD patients could have safe pregnancies with minimum damage to the fetus under reasonable planning and effective immunosuppressive treatments. Conceiving after remission for at least six months and maintaining immunotherapy during pregnancy and postpartum periods may be helpful to decrease the risk of pregnancy-related relapse.

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