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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (05) : 367 -370. doi: 10.3877/cma.j.issn.1674-0785.2019.05.009

所属专题: 文献

临床研究

CT图像纹理分析对小于10 mm纯磨玻璃结节侵袭性的诊断价值
毛海霞1, 徐蒙莱1, 冯银波1, 陈宏伟1, 方向明1,()   
  1. 1. 214023 南京医科大学附属无锡市人民医院影像科
  • 收稿日期:2018-12-11 出版日期:2019-03-01
  • 通信作者: 方向明

CT texture analysis in diagnosis of invasiveness of lung adenocarcinoma manifesting as pure ground glass nodules less than 10 mm

Haixia Mao1, Menglai Xu1, Yinbo Feng1, Hongwei Chen1, Xiangming Fang1,()   

  1. 1. Department of Radiology, Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, China
  • Received:2018-12-11 Published:2019-03-01
  • Corresponding author: Xiangming Fang
  • About author:
    Corresponding author: Fang Xiangming, Email:
引用本文:

毛海霞, 徐蒙莱, 冯银波, 陈宏伟, 方向明. CT图像纹理分析对小于10 mm纯磨玻璃结节侵袭性的诊断价值[J/OL]. 中华临床医师杂志(电子版), 2019, 13(05): 367-370.

Haixia Mao, Menglai Xu, Yinbo Feng, Hongwei Chen, Xiangming Fang. CT texture analysis in diagnosis of invasiveness of lung adenocarcinoma manifesting as pure ground glass nodules less than 10 mm[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(05): 367-370.

目的

探讨CT图像纹理分析对小于10 mm纯磨玻璃结节的侵袭性的诊断价值。

方法

收集2015年1月至2017年3月在无锡市人民医院行手术治疗的<10 mm纯磨玻璃结节148例,其中浸润前病变组73例,浸润性病变组75例,运用ImageJ软件对其图像进行纹理特征提取,并找出2组有差别的参数,运用Spearman相关性分析进行特征性降维,找出独立的预测因子,再运用受试者工作特征曲线评价独立预测因子的诊断效能。

结果

影像特征提取得到31个CT图像纹理特征参数,差异有统计学意义的参数有19个,经降维处理最终得到3个与肺腺癌浸润性相关的独立参数,即角二阶矩、相关性和逆差矩,曲线下面积分别为0.715、0.720、0.736。

结论

CT图像纹理分析对判断早期肺腺癌的浸润性有一定的诊断价值。

Objective

To assess the value of CT texture analysis in diagnosing the invasiveness of lung adenocarcinoma manifesting as pure ground glass nodules less than 10 mm.

Methods

The preoperative CT data of 148 patients manifesting as pure ground glass nodules less than 10 mm who underwent operation were analyzed retrospectively. Among 148 cases of pure ground glass nodules, 73 were preinvasive lesions and 75 were invasive lesions of lung adenocarcinoma. ImageJ software was used to extract the texture features of the images and then the parameters that differed significantly between the preinvasive lesions and invasive lesions were identified. Spearman correlation analysis was used for feature dimension reduction, and then independent predictors were selected out. Receiver operator characteristic curve was then used to evaluate the diagnostic efficiency of independent predictors.

Results

Among 31 parameters of texture feature obtained by CT feature extraction, 19 statistically differed between the two groups. Three independent parameters related to lung adenocarcinoma invasiveness were obtained after dimension reduction, which were angular second moment, contrast, and inverse difference moment. The areas under the curves of the three parameters for diagnosing the invasiveness of early lung adenocarcinoma were 0.715, 0.720, and 0.736, respectively.

Conclusion

CT texture analysis is helpful in the diagnosis of invasiveness of early lung adenocarcinoma.

图1 浸润前病变和浸润性病变角二阶矩、相关性和逆差矩的受试者工作特征曲线
表1 浸润前病变组和浸润性病变组有差异的特征性参数(±s
表2 浸润前病变和浸润性病变曲线下面积及其95%可信区间
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