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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (08) : 643 -647. doi: 10.3877/cma.j.issn.1674-0785.2020.08.012

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综述

腺相关病毒在帕金森病研究中的应用进展
何天齐1, 张晓韬1, 王敏2, 李秀华3,()   
  1. 1. 261053 山东潍坊,潍坊医学院
    2. 250014 济南,山东师范大学生命科学学院动物抗性重点实验室
    3. 250014 济南,山东第一医科大学第一附属医院神经内科
  • 收稿日期:2020-02-28 出版日期:2020-08-15
  • 通信作者: 李秀华
  • 基金资助:
    山东省重大科技创新工程项目(2018CXGC1502)

Application of adeno-associated virus in Parkinson′s disease

Tianqi He1, Xiaotao Zhang1, Min Wang2, Xiuhua Li3,()   

  1. 1. Weifang Medical University, Weifang 261053, China
    2. Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, China
    3. Department of Neurology, the First Affiliated Hospital of Shandong First Medical University, Jinan 250014, China
  • Received:2020-02-28 Published:2020-08-15
  • Corresponding author: Xiuhua Li
  • About author:
    Corresponding author: Li Xiuhua, Email:
引用本文:

何天齐, 张晓韬, 王敏, 李秀华. 腺相关病毒在帕金森病研究中的应用进展[J]. 中华临床医师杂志(电子版), 2020, 14(08): 643-647.

Tianqi He, Xiaotao Zhang, Min Wang, Xiuhua Li. Application of adeno-associated virus in Parkinson′s disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(08): 643-647.

帕金森病是常见于中老年的中枢神经系统变性疾病,主要发病机制尚不明确。目前治疗策略旨在减轻症状和减缓疾病的进展。腺相关病毒(AAV)介导的基因传递应用包括神经生物学研究、疾病模型和基因治疗。AAV作为神经示踪剂可用于探索基底节环路,为帕金森病发病机制的研究提供理论依据;AAV载体编码的治疗基因,为帕金森病的治疗带来了广阔前景。近年来,国内外相继开展了AAV用于帕金森病的动物实验和临床研究,取得了一定的进展。如何更好地利用AAV治疗帕金森病,又能将不良反应降到最低,成为未来学术界研究的热点。

Parkinson′s disease is a degenerative disease of the central nervous system that is common in middle-aged and elderly people, and its pathogenesis is still largely unclear. Current treatment strategies are aimed at reducing symptoms and slowing the progression of the disease. The applications of adeno-associated virus-mediated gene delivery include neurobiological research, disease modelling, and gene therapy. Adeno-associated virus as a neurotracer can be used to explore the basal ganglia circuit, providing an important tool for the research of the pathogenesis of Parkinson′s disease. The use of therapeutic genes carried by adeno-associated virus vectors has brought broad therapeutic prospects to Parkinson′s disease. In recent years, animal experiments and clinical studies of adeno-associated viruses for Parkinson′s disease have been carried out both in China and other countires, and some progress has been made. How to make better use of adeno-associated viruses and minimize the adverse reactions will become a hot research topic in the future.

图1 病毒载体的神经元投射关系[8]
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