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中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (11) : 886 -889. doi: 10.3877/cma.j.issn.1674-0785.2020.11.007

所属专题: 乳腺疾病 经典病例 文献

乳腺癌·临床研究

炎性乳腺癌新辅助放疗四例临床分析并文献复习
李晓梅1, 高献书1,()   
  1. 1. 100034 北京,北京大学第一医院放射治疗科
  • 收稿日期:2020-09-16 出版日期:2020-11-15
  • 通信作者: 高献书

Neoadjuvant radiotherapy for inflammatory breast cancer: a clinical analysis of four cases and literature review

Xiaomei Li1, Xianshu Gao1,()   

  1. 1. Department of Radiotherapy, Peking University First Hospital, Beijing 100034, China
  • Received:2020-09-16 Published:2020-11-15
  • Corresponding author: Xianshu Gao
引用本文:

李晓梅, 高献书. 炎性乳腺癌新辅助放疗四例临床分析并文献复习[J]. 中华临床医师杂志(电子版), 2020, 14(11): 886-889.

Xiaomei Li, Xianshu Gao. Neoadjuvant radiotherapy for inflammatory breast cancer: a clinical analysis of four cases and literature review[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(11): 886-889.

目的

通过4例炎性乳腺癌新辅助放疗病例及文献复习,分析探讨炎性乳腺癌新辅助放疗的可行性。

方法

回顾性分析4例临床分期为T4dN1~3M0的炎性乳腺癌患者,新辅助全身治疗失败后加用新辅助放疗,观察其疗效,并回顾分析相关文献。

结果

4例炎性乳腺癌患者新辅助放疗后均获得临床缓解,成功进行乳腺癌改良根治术。术后无严重并发症,手术切口愈合良好,无坏死。1例患者术后病理完全缓解,3例部分缓解。中位随访时间26个月(18~103个月),1例胸壁复发,2例肺、纵隔淋巴结转移,1例无复发转移。1例死亡(肺转移)。

结论

精确放射治疗技术对新辅助全身治疗失败的炎性乳腺癌患者进行新辅助放疗,安全有效。

Objective

To analyze the feasibility of neoadjuvant radiotherapy for inflammatory breast cancer by reviewing four cases and performed a literature review.

Methods

Four patients with inflammatory breast cancer (clinical stage T4dN1-3M0) were treated with neoadjuvant radiotherapy after the failure of neoadjuvant systemic therapy, and the curative effect was observed. A review of the relevant literature was performed.

Results

All the four patients with inflammatory breast cancer achieved clinical remission after neoadjuvant radiotherapy, and modified radical mastectomy was performed successfully. There were no serious complications after operation, and the incision healed well and there was no necrosis. Postoperative complete pathological remission was achieved in one case and partial remission in three. The median follow-up period was 26 months (18-103 months). One case developed chest wall recurrence, two developed lung and mediastinal lymph node metastasis, and one had no recurrence or metastasis. One case died of lung metastasis.

Conclusion

With the progress of radiotherapy technology, neoadjuvant radiotherapy can be considered as a safe and effective alternative treatment for inflammatory breast cancer patients when neoadjuvant systemic therapy failed.

表1 新辅助放疗前炎性乳腺癌患者临床特征
图1 病例3患者采用旋转调强放射治疗情况 a为横断位剂量曲线分步,b为冠状位剂量曲线分步
图2 病例3肿瘤及皮肤变化 a为放疗前;b为术前(放疗后4周);c为术后1周
表2 新辅助放疗后炎性乳腺癌患者疗效及转归
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