切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 47 -51. doi: 10.3877/cma.j.issn.1674-0785.2021.01.009

所属专题: 文献

综述

结直肠癌肿瘤标志物的研究进展
王泓懿1,()   
  1. 1. 102206 北京,北京大学国际医院消化内科
  • 收稿日期:2020-08-26 出版日期:2021-01-15
  • 通信作者: 王泓懿

Progress in research of tumor markers in colorectal cancer

Hongyi Wang1,()   

  1. 1. Department of Gastroenterology, Peking University International Hospital, Beijing 102206, China
  • Received:2020-08-26 Published:2021-01-15
  • Corresponding author: Hongyi Wang
引用本文:

王泓懿. 结直肠癌肿瘤标志物的研究进展[J/OL]. 中华临床医师杂志(电子版), 2021, 15(01): 47-51.

Hongyi Wang. Progress in research of tumor markers in colorectal cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(01): 47-51.

结直肠癌是目前最常见消化道恶性肿瘤之一。由于这类疾病早期常无症状,往往诊断较晚,导致该疾病的死亡率一直居高不下。因此,结直肠癌的早发现、早诊断、早治疗显得尤为重要,而目前其诊断主要依赖内镜、影像学检查以及肿瘤标志物等血清学检查。其中,肿瘤标志物在结直肠癌的诊断、预后判断及检测复发等方面具有重大意义。因此,迫切需要发现可用于结直肠癌早期检测的新型血清生物学标志物。本文对近年来与结直肠癌相关的肿瘤标志物研究进展进行综述,从而指导患者的诊疗及预后判断,发现联合多种肿瘤标志物检测有更高的准确性。

Colorectal cancer is one of the most common malignant tumors of the digestive system. Because colorectal cancer is often asymptomatic at early stages and diagnosed late, its mortality rate is high. Therefore, early detection, diagnosis, and treatment of colorectal cancer are particularly important. At present, colorectal cancer diagnosis depends mainly on endoscopy, imaging examination, and serological examination of tumor markers. Among them, tumor markers detection is an extremely significant method in the diagnosis, prognosis judgment, and detection of recurrence. Therefore, there is an urgent need to find new serum biomarkers for early detection of colorectal cancer. In this paper, we review the progress in the research of tumor markers related to colorectal cancer in recent years, with an aim to guide the diagnosis and estimate the prognosis of colorectal cancer patients. We also suggest that the simultaneous detection of multiple tumor markers has higher accuracy.

1
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. Ca Cancer J Clin, 2018, 68(6): 394-424
2
Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017 [J]. CA Cancer J Clin, 2017, 67(3): 177-193.
3
王光彦, 李海燕, 杨思俊, 等. 肿瘤标志物的研究发展及临床应用 [J]. 中国保健营养, 2017, 27(9): 429.
4
You W, Yan L, Cai Z, et al. Clinical significances of positive postoperative serum CEA and post-preoperative CEA increment in stage II and III colorectal cancer: a multicenter retrospective study [J]. Front Oncol, 2020, 10: 671.
5
Hermunen K, Soveri LM, Boisen MK, et al. Postoperative serum CA19-9, YKL-40, CRP and IL-6 in combination with CEA as prognostic markers for recurrence and survival in colorectal cancer [J]. Acta Oncol, 2020, 59(12): 1416-1423.
6
Peltonen R, Gramkow MH, Dehlendorff C, et al. Elevated serum YKL-40, IL-6, CRP, CEA, and CA19-9 combined as a prognostic biomarker panel after resection of colorectal liver metastases [J]. PLoS ONE, 2020, 15(8): e0236569.
7
Hess KR, Varadhachary GR, Taylor SH, et al. Metastatic patterns in adenocarcinoma [J]. Cancer, 2006, 106(7): 1624-1633.
8
Min YL, Gong YX, Zhu PW, et al. CEA as a risk factor in predicting ocular metastasis from colorectal cancer [J]. J Cancer, 2020, 11(1): 51-56.
9
Lu Z, Peng J, Wang Z, et al. High preoperative serum CA19-9 level is predictive of poor prognosis for patients with colorectal liver oligometastases undergoing hepatic resection [J]. Med Oncol, 2016, 33(11): 121.
10
Stiksma J, Grootendorst DC, van der Linden PW. CA 19-9 as a marker in addition to CEA to monitor colorectal cancer [J]. Clin Colorectal Cancer, 2014, 13(4): 239-244.
11
Okamura R, Hasegawa S, Hida K, et al. Japanese study group for postoperative follow-up of colorectal cancer. The role of periodic serum CA19-9 test in surveillance after colorectal cancer surgery [J]. Int J Clin Oncol, 2017, 22(1): 96-101.
12
尚永明, 陈群, 李新明. 血清CEA、CA19-9及CA72-4联合检测预测转移性直肠癌患者化疗后预后的价值分析 [J]. 临床和实验医学杂志, 2018, 267(11): 65-67.
13
姜涛. 胃肠肿瘤标志物诊断大肠癌的检验医学研究 [J/OL]. 临床检验杂志(电子版), 2018, 7(1): 32-33.
14
Zhong W, Yu Z, Zhan J, et al. Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer [J]. Pathol Oncol Res, 2015, 21(1): 83-95.
15
Bahrami A, Hesari AR, Khazaei M, et al. The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer [J]. J Cell Physiol, 2018, 233(3): 2162-2169.
16
Afrăsânie VA, Marinca MV, Alexa-Stratulat T, et al. KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer-practical implications for the clinician [J]. Radiol Oncol, 2019, 53(3): 265-274.
17
Rui Y, Wang C, Zhou Z, et al. K-Ras mutation and prognosis of colorectal cancer: a meta-analysis [J]. Hepatogastroenterology, 2015, 62(137): 19-24.
18
刘佳明, 刘伟, 徐达, 等. RAS基因突变对结直肠癌肝转移患者肝切除术后预后的影响 [J]. 中华肝胆外科杂志, 2020, 26(1): 1-5.
19
Selcukbiricik F, Bilici A, Tural D, et al. Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer? [J]. Tumour Biol, 2013, 34(4): 2233-2239.
20
郭源, 张龙, 张舜, 等. 结直肠癌错配修复蛋白表达及微卫星不稳定与TNM分期的相关性 [J]. 肿瘤研究与临床, 2019, 31(6): 376-380.
21
柴华, 金翔宇, 金霞云, 等. 微卫星不稳定、HER2与结直肠癌恶性程度相关 [J]. 基础医学与临床, 2019, 39(2): 218-221.
22
Goldstein J, Tran B, Ensor J, et al. Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H) [J]. Ann Oncol, 2014, 25(5): 1032-1038.
23
Jiang Y, Zhang C, Chen K, et al. The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer [J]. PLoS One, 2014, 9(12): e114748.
24
于海涛, 曲义坤, 于海波, 等. 外周血内基质金属蛋白酶-7, 糖类抗原242在直肠癌诊断及术后评估中的价值 [J]. 中国老年学杂志, 2018, 38(9): 55-57.
25
马顺茂, 贾漪涛, 刘红磊, 等. 结直肠癌组织中基质金属蛋白酶-10的表达及临床意义 [J]. 中国全科医学, 2011, 14(2): 161-163.
26
刘爽, 赵冬雪. 基质金属蛋白酶12的研究进展 [J]. 医学综述, 2018, 24(14): 2781-2786.
27
Klupp F, Neumann L, Kahlert C, et al. Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients [J]. BMC Cancer, 2016, 16: 494.
28
Takiyyuddin MA, Cervenka JH, Sullivan PA, et al. Is physiologic sympathoadrenal catecholamine release exocytotic in humans? [J]. Circulation, 1990, 81(1): 185-195.
29
Zhang X, Zhang H, Shen B, Sun XF. Chromogranin-A expression as a novel biomarker for early diagnosis of colon cancer patients [J]. Int J Mol Sci, 2019, 20(12): 2919.
30
陈静静, 门万琪, 成祖群, 等. 结肠癌患者血清IL-6, CEA和CA19-9联合检测的临床意义 [J]. 免疫学杂志, 2013, 29(12): 1071-1073.
31
李欣欣, 陈焕杰, 庄少惠, 等. 白介素-17在结肠癌中的表达及意义 [J]. 汕头大学医学院学报, 2019, 32(2): 82-85.
32
Hu WH, Chen HH, Yen SL, et al. Increased expression of interleukin‐23 associated with progression of colorectal cancer [J]. J Surg Oncol, 2017, 115(2): 208-212.
33
Zeng JC, Zhang Z, Li TY, et al. Assessing the role of IL-35 in colorectal cancer progression and prognosis [J]. Int J Clin Exp Pathol, 2013, 6(9): 1806-1816.
34
Chen F, Zhang F, Tan Z, et al. Interleukin-38 in colorectal cancer: a potential role in precision medicine [J]. Cancer Immunol Immunother, 2020, 69(1): 69-79.
35
Esmaeili M, Keshani M, Vakilian M, et al. Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways [J]. Gene, 2020, 753: 144796.
36
Perakis SO, Thomas JE, Pichler M. Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients [J]. Adv Exp Med Biol, 2016, 937: 183-204.
37
Wang L, Cho KB, Li Y, et al. Long Noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer [J]. Int J Mol Sci, 2019, 20(22): 5758.
38
Hao S, Yao L, Huang J, et al. Genome-wide analysis identified a number of dysregulated long noncoding RNA (lncRNA) in human pancreatic ductal adenocarcinoma [J]. Technol Cancer Res Treat, 2018, 17: 1533034617748429.
39
Jing H, Qu X, Liu L, Xia H, et al. A novel long noncoding RNA (lncRNA), LL22NC03-N64E9.1, promotes the proliferation of lung cancer cells and is a potential prognostic molecular biomarker for lung cancer [J]. Med Sci Monit, 2018, 24: 4317-4323.
40
Robbins SL, Cotran RS. Robbins and cotran pathological basis of disease (7th Edition)[M]. New York: Elsevier Saunders, 2005: 314-316.
[1] 王亚红, 蔡胜, 葛志通, 杨筱, 李建初. 颅骨骨膜窦的超声表现一例[J/OL]. 中华医学超声杂志(电子版), 2024, 21(11): 1089-1091.
[2] 唐金侨, 叶宇佳, 王港, 赵彬, 马艳宁. 医学影像学检查方法在颞下颌关节紊乱病中临床应用研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 406-411.
[3] 熊鹰, 林敬莱, 白奇, 郭剑明, 王烁. 肾癌自动化病理诊断:AI离临床还有多远?[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 535-540.
[4] 陈樽, 王平, 金华, 周美玲, 李青青, 黄永刚. 肌肉减少症预测结直肠癌术后切口疝发生的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 639-644.
[5] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[6] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[7] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[8] 孙晗, 于冰, 武侠, 周熙朗. 基于循环肿瘤DNA 甲基化的结直肠癌筛查预测模型的构建与验证[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 500-506.
[9] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
[10] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
[11] 李浩, 陈棋帅, 费发珠, 张宁伟, 李元东, 王硕晨, 任宾. 慢性肝病肝纤维化无创诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 863-867.
[12] 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
[13] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[14] 陈慧, 邹祖鹏, 周田田, 张艺丹, 张海萍. 皮肤镜对头皮红斑性皮肤病辅助鉴别诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 692-698.
[15] 胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
阅读次数
全文


摘要