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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 61 -64. doi: 10.3877/cma.j.issn.1674-0785.2021.01.012

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综述

肌肉减少症与维生素D关系的研究进展
李林雪1, 朱亦堃2,()   
  1. 1. 030001 太原,山西医科大学第二临床医学院
    2. 030001 太原,山西医科大学第二医院内分泌科
  • 收稿日期:2020-08-13 出版日期:2021-01-15
  • 通信作者: 朱亦堃

Progress in understanding of relationship between sarcopenia and vitamin D

Linxue Li1, Yikun Zhu2,()   

  1. 1. The Second Clinical College of Shanxi Medical University, Taiyuan 030001, China
    2. Department of Endocrinology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2020-08-13 Published:2021-01-15
  • Corresponding author: Yikun Zhu
引用本文:

李林雪, 朱亦堃. 肌肉减少症与维生素D关系的研究进展[J]. 中华临床医师杂志(电子版), 2021, 15(01): 61-64.

Linxue Li, Yikun Zhu. Progress in understanding of relationship between sarcopenia and vitamin D[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(01): 61-64.

随着全球人口老龄化程度的日益加重,肌肉减少症将是未来社会面临的主要健康问题之一,严重影响患者的生活质量和生存。维生素D水平可通过复杂的调控机制对肌细胞及骨骼肌功能产生影响,应重视肌肉减少症老年人群的维生素D营养状况,及时适量补充,对改善肌肉质量和力量、改善活动障碍、降低跌倒风险、提高生活质量至关重要。

With the increasing aging of the global population, sarcopenia will be one of the major health problems in the future, which will seriously affect the quality of life and survival of patients. The level of vitamin D can affect muscle cells and the function of skeletal muscle through complex regulatory mechanisms. Therefore, attention should be paid to the nutritional status of vitamin D in the elderly population with sarcopenia, and timely and appropriate supplementation is essential to improve muscle quality and strength, improve mobility disorders, reduce the risk of falls, and improve the quality of life.

1
Fan JJ, Kou XJ, Jia SH, et al. Autophagy as a potential target for sarcopenia [J]. J Cell Physiol, 2016, 231(7): 1450-1459.
2
Yoon MS. mTOR as a key regulator in maintaining skeletal muscle mass [J]. Front Physiol, 2017, 8: 788.
3
Glass DJ. Skeletal muscle hypertrophy and atrophy signaling pathways [J]. Int J Biochem Cell Biol, 2005, 37(10): 1974-1984.
4
Żebrowska A, Sadowska-Krępa E, Stanula A, et al. The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners [J]. J Int Soc Sports Nutr, 2020, 17(1): 18.
5
Cartee GD, Funai K. Exercise and insulin: convergence or divergence at AS160 and TBC1D1? [J]. Exerc Sport Sci Rev, 2009, 37(4): 188-195.
6
Powers SK, Smuder AJ, Judge AR. Oxidative stress and disuse muscle atrophy: cause or consequence? [J]. Curr Opin Clin Nutr Metab Care, 2012, 15(3): 240-245.
7
Mastrocola R, Reffo P, Penna F, et al. Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress [J]. Free Radic Biol Med, 2008, 44(4): 584-593.
8
Lexell J, Taylor CC, Sjöström M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men [J]. J Neurol Sci, 1988, 84(2-3): 275-294.
9
Doherty TJ, Brown WF. Age-related changes in the twitch contractile properties of human thenar motor units [J]. J Appl Physiol, 1997, 82(1): 93-101.
10
Kadoguchi T, Shimada K, Miyazaki T, et al. Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice [J]. Geriatr Gerontol Int, 2020, 20(1): 78-84.
11
Calvani R, Miccheli A, Landi F, et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia [J]. J Frailty Aging, 2013, 2(1): 38-53.
12
Girgis CM. Vitamin D and skeletal muscle: emerging roles in development, anabolism and repair [J]. Calcif Tissue Int, 2020, 106(1): 47-57.
13
Morelli S, Buitrago C, Boland R, et al. The stimulation of MAP kinase by 1, 25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium [J]. Mol Cell Endocrinol, 2001, 173(1-2): 41-52.
14
Buitrago CG, Pardo VG, de-Boland AR, et al. Activation of RAF-1 through Ras and protein kinase Calpha mediates 1alpha, 25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells [J]. J Biol Chem, 2003, 278(4): 2199-2205.
15
Garcia LA, King KK, Ferrini MG, et al. 1, 25(OH)2 vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells [J]. Endocrinology, 2011, 152(8): 2976-2986.
16
Endo I, Inoue D, Mitsui T, et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors [J]. Endocrinology, 2003, 144(12): 5138-5144.
17
Girgis CM, Clifton-Bligh RJ, Mokbel N, et al. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells [J]. Endocrinology, 2014, 155(2): 347-357.
18
Girgis CM, Cha KM, Houweling PJ, et al. Vitamin D receptor ablation and vitamin D deficiency result in reduced grip strength, altered muscle fibers, and increased myostatin in mice [J]. Calcif Tissue Int, 2015, 97(6): 602-610.
19
Chen S, Villalta SA, Agrawal DK. FOXO1 mediates vitamin D deficiency-induced insulin resistance in skeletal muscle [J]. J Bone Miner Res, 2016, 31(3): 585-595.
20
Bhat M, Kalam R, Qadri SS, et al. Vitamin D deficiency-induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats [J]. Endocrinology, 2013, 154(11): 4018-4029.
21
Bhat M, Ismail A. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis [J]. J Steroid Biochem Mol Biol, 2015, 152: 171-179.
22
Al-Eisa ES, Alghadir AH, Gabr SA. Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults [J]. Clin Interv Aging, 2016, 11: 513-522.
23
Laurson KR, Thomas JN, Barnes JL. Vitamin D status is associated with muscular strength in a nationally representative sample of US youth [J]. Acta Paediatr, 2020, 109(12): 2755-2761.
24
Tague SE, Clarke GL, Winter MK, et al. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation [J]. J Neurosci, 2011, 31(39): 13728-13738.
25
Sakai S, Suzuki M, Tashiro Y, et al. Vitamin D receptor signaling enhances locomotive ability in mice [J]. J Bone Miner Res, 2015, 30(1): 128-136.
26
Broe KE, Chen TC, Weinberg J, et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study [J]. J Am Geriatr Soc, 2007, 55(2): 234-239.
27
Muir SW, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis [J]. J Am Geriatr Soc, 2011, 59(12): 2291-2300.
28
Brunner RL, Cochrane B, Jackson RD, et al. Calcium, vitamin D supplementation, and physical function in the women's health initiative [J]. J Am Diet Assoc, 2008, 108(9): 1472-1479.
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