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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (04) : 491 -495. doi: 10.3877/cma.j.issn.1674-0785.2023.04.022

综述

智能化靶控输注药代模型的研究进展
赖志豪(), 路延, 欧阳锌澄, 宋可欣   
  1. 510150 广州,广州医科大学附属第三医院麻醉科
    510010 广州,南部战区总医院麻醉科
  • 收稿日期:2022-03-19 出版日期:2023-04-15
  • 通信作者: 赖志豪

Progress in research of pharmacokinetic models for intelligent target controlled infusion

Zhihao Lai(), Yan Lu, Xincheng OuYang, Kexin Song   

  1. Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
    Department of Anesthesiology, General Hospital of Southern Theatre Command, Guangzhou 510010, China
  • Received:2022-03-19 Published:2023-04-15
  • Corresponding author: Zhihao Lai
引用本文:

赖志豪, 路延, 欧阳锌澄, 宋可欣. 智能化靶控输注药代模型的研究进展[J/OL]. 中华临床医师杂志(电子版), 2023, 17(04): 491-495.

Zhihao Lai, Yan Lu, Xincheng OuYang, Kexin Song. Progress in research of pharmacokinetic models for intelligent target controlled infusion[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 491-495.

靶控输注(TCI)是一种静脉输注药物以达到特定体室或组织预设浓度(靶浓度)的给药技术。医学大数据时代的到来,TCI技术日趋成熟,一方面,为实现现代麻醉的智能化,自动给药系统的开发研究逐渐得到重视;另一方面,TCI药代模型的优化则强调了麻醉的个体化。本文就现代医学背景下TCI多通道闭环系统与药代模型优化的研究进展进行综述,为探究TCI的发展趋势提供参考。

Target controlled infusion (TCI) is a technique of infusing intravenous drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. TCI is becoming widely used with the advent of big data in medicine. In order to realize the intellectualization of modern anesthesia, more attention has been paid to the development and research of automatic drug delivery systems, while the optimization of TCI models emphasizes the individualization of anesthesia. This review intends to link TCI to modern medicine and thus to illustrate the multichannel closed-loop system and the optimization of pharmacokinetic models, which will characterize the future development of TCI.

图1 PTCI模型 注:PTCI为药物效应动力学模型控制的靶控输注
图2 复杂生理模型示意图 注:器官“Portal”为所有血流被门静脉收集的器官。结缔组织分为两个器官,“Tendon”的血流灌输相对低;“Other”的血流灌注相对较高
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