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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (10) : 798 -802. doi: 10.3877/cma.j.issn.1674-0785.2025.10.011

综述

细胞泛凋亡与癌症的关系研究进展
丁洪基, 王贵珍(), 王灿, 李龙龙   
  1. 257000 东营,山东大学齐鲁医院东营分院病理科
  • 收稿日期:2025-10-28 出版日期:2025-10-30
  • 通信作者: 王贵珍

Relationship between PANoptosis and cancer: an update

Hongji Ding, Guizhen Wang(), Can Wang, Longlong Li   

  1. Department of Pathology, Qilu Hospital of Shandong University at Dongying, Dongying 257000, China
  • Received:2025-10-28 Published:2025-10-30
  • Corresponding author: Guizhen Wang
引用本文:

丁洪基, 王贵珍, 王灿, 李龙龙. 细胞泛凋亡与癌症的关系研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(10): 798-802.

Hongji Ding, Guizhen Wang, Can Wang, Longlong Li. Relationship between PANoptosis and cancer: an update[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(10): 798-802.

泛凋亡是近年来新发现的一种独特的炎症细胞死亡模式,它融合了细胞凋亡、焦亡和坏死性凋亡的主要特征及相互作用,由先天免疫传感器发起,通过泛凋亡小体驱动。泛凋亡是目前已知的最复杂的程序性细胞死亡(PCD)形式之一,它与人类多种全身性疾病的发展密切相关,包括传染病、癌症、神经退行性疾病和炎症性疾病。因此,了解泛凋亡的发病机制,为人类疾病的治疗提供依据具有重要意义。泛凋亡在肿瘤治疗中的作用是多方面的,包括抑制肿瘤生长,提高化疗敏感性,预测治疗反应和预后,促进免疫监测等。鉴于泛凋亡在整个疾病谱中的影响,靶向其分子成分为疾病的治疗提供了巨大的潜力。

PANoptosis is a unique inflammatory cell death pattern newly discovered in recent years. It integrates the main features and interactions of apoptosis, pyroptosis, and necroptosis, initiated by innate immune sensors and driven by PANoptosome. As one of the most intricate forms of programmed cell death (PCD) identified to date, PANoptosis is closely related to the pathogenesis of various systemic diseases in humans, including infectious diseases, cancer, neurodegenerative disorders, and inflammatory conditions. Therefore, understanding the pathogenesis of PANoptosis is of great significance for providing a basis for the treatment of human diseases. The role of PANoptosis in tumor treatment is multi-faceted, including inhibiting tumor growth, enhancing chemotherapy sensitivity, predicting treatment response and prognosis, and promoting immune monitoring. Given the impact of PANoptosis across the entire disease spectrum, targeting its molecular components offers great potential for the treatment of diseases.

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