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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (11) : 860 -865. doi: 10.3877/cma.j.issn.1674-0785.2025.11.010

综述

微生物-肠-脑轴在注意缺陷多动障碍中的研究进展
史若琳, 何凡()   
  1. 100088 北京,首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室 人脑保护高精尖创新中心
  • 收稿日期:2025-10-28 出版日期:2025-11-30
  • 通信作者: 何凡
  • 基金资助:
    首都卫生发展科研专项资助(首发2024-1-2123); 北京市科学技术委员会资助(Z201100005520076); 高层次公共卫生技术人才建设项目资助(学科带头人-02-01); 北京市属医院科研培育项目(PX2024067)

Advances in understanding the role of the microbiota-gut-brain axis in attention deficit hyperactivity disorder

Ruolin Shi, Fan He()   

  1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100088, China
  • Received:2025-10-28 Published:2025-11-30
  • Corresponding author: Fan He
引用本文:

史若琳, 何凡. 微生物-肠-脑轴在注意缺陷多动障碍中的研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(11): 860-865.

Ruolin Shi, Fan He. Advances in understanding the role of the microbiota-gut-brain axis in attention deficit hyperactivity disorder[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(11): 860-865.

注意缺陷多动障碍(ADHD)是儿童期常见的神经发育障碍,主要表现为注意力不集中、多动及冲动,其患病率估计约为8.0%并常持续至成年。传统机制主要聚焦于脑内多巴胺与去甲肾上腺素通路异常,而日益增多的研究将视角扩展至微生物-肠-脑轴(MGBA),揭示肠道微生物群通过神经、内分泌及免疫通路参与ADHD的发生与发展。本文综述了近期关于ADHD患儿肠道菌群特征、MGBA通路及干预研究的最新进展,旨在为肠–脑轴在ADHD研究中的机制解析与精准干预策略提供参考。

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, primarily characterized by inattention, impulsivity, and hyperactivity. With an estimated prevalence of approximately 8.0%, ADHD often persists into adulthood. Traditional explanations of its pathophysiological mechanisms mainly focus on abnormalities in the dopamine and norepinephrine pathways in the brain. However, a growing body of research is expanding the perspective to the microbiota-gut-brain axis (MGBA), revealing that the gut microbiota is involved in the pathogenesis and development of ADHD through neural, endocrine, and immune pathways. This article reviews recent advances in the understanding of the characteristics of the gut microbiota in children with ADHD, the MGBA pathways involved, and related intervention studies, aiming to provide insights for understanding the mechanisms of the gut-brain axis in ADHD and developing precise intervention strategies.

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