A comparative study of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure

doi:10.3877/cma.j.issn.1674-0785.2017.11.005

Abstract

Abstract:

Objective

To compare the effect of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure.

Methods

One-step and two-step approach were used to establish the model of 5/6 nephrectomy, and the mortality rate and the levels of creatinine and urea nitrogen were recorded in the two groups at the end of week 4, week 8 and week 12 after the operation.

Results

The mortality rate was 17.65% in the one-step group at the end of the 4th week, compared with 29.41% in the two-step group at the same time after the operation. The renal failure models were successfully established in the two groups, and there was no significant difference in the levels of creatinine and urea nitrogen between the two groups at the end of the 8th week.

Conclusion

One-step and two-step approach can successfully establish 5/6 nephrectomy model of renal failure, and the one-step approach may produce lower mortality.

Key words: 5/6 Nephrectomy, Renal failure

Jian Zhang, Jijun Li, Yan Song. A comparative study of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(11): 1886-1888.

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References 7

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组别	只数	4周死亡率	8周死亡率
假手术组	6	1（16.67）	1（16.67）
两步法组	17	5（29.41）	6（35.29）
一步法组	17	3（17.65）^a	4（23.53）^a

组别	只数	4周死亡率	8周死亡率
假手术组	6	1（16.67）	1（16.67）
两步法组	17	5（29.41）	6（35.29）
一步法组	17	3（17.65）^a	4（23.53）^a

组别	只数	4周	8周	12周
假手术组	6	42.33±9.63	41.57±7.24	40.26±10.24
一步法手术组	17	86.42±15.61^a	100.22±17.84^a	164.33±20.82^a
两步法手术组	17	60.73±11.52^a	105.72±15.36^a	154.82±19.67^a

组别	只数	4周	8周	12周
假手术组	6	42.33±9.63	41.57±7.24	40.26±10.24
一步法手术组	17	86.42±15.61^a	100.22±17.84^a	164.33±20.82^a
两步法手术组	17	60.73±11.52^a	105.72±15.36^a	154.82±19.67^a

组别	只数	4周	8周	12周
假手术组	6	6.67±2.03	6.89±1.94	6.73±1.71
一步法手术组	17	12.36±3.42^a	14.72±4.72^a	16.33±4.29^a
两步法手术组	17	10.38±1.84^a	15.36±4.89^a	15.98±5.33^a

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