This article provides a reflective overview of my academic career in parallel with the development of psychosomatic medicine in China. From a junior physician to the current chair of the Psychosomatic Medicine Branch of the Chinese Medical Association, I have witnessed the discipline's evolution from its nascent stage to a thriving field. Psychosomatic medicine traces its origins to the traditional Chinese philosophy of the unity of body and mind. It progressed through its early origin, initial establishment, rapid expansion, and significant advancement, evolving into a discipline with distinct Chinese characteristics. A national psychosomatic medicine service network has been established, actively promoting regional branches and specialized collaborative groups. In addition, professional personal development, social education, continuing education programs, and science communication initiatives have been implemented to enhance social awareness. Last, the criteria include the 'Chinese Guidelines for the Standardized Diagnosis and Treatment of Psychosomatic-related Disorders' that have been formed and published. Looking ahead, we will continue to advance basic research, refine the psychosomatic health care system, foster professional growth, and elevate Chinese psychosomatic medicine's global presence and influence.

To evaluate the safety and efficacy of zero-contrast percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) in patients with acute coronary syndrome (ACS) and contrast agent contraindications.

A retrospective analysis was conducted on the clinical data of acute coronary syndrome (ACS) patients who underwent IVUS-guided zero-contrast PCI at the Department of Cardiology, Peking University Third Hospital from January 2021 to December 2024. Data collected included demographic information, medical history, IVUS-assessed coronary lesion characteristics, procedural details, and follow-up cardiovascular events.

A total of 8 ACS patients with contrast agent contraindications underwent IVUS-guided zero-contrast PCI, including 4 with severe contrast allergy and 4 with chronic kidney disease. All patients successfully completed the procedure without in-procedure complications such as dissection, hematoma, or occlusion. During a follow-up period of 1~3.5 years, no major adverse cardiovascular events (MACEs) occurred.

IVUS-guided zero-contrast PCI provides a safe and effective treatment option for ACS patients with contrast agent contraindications. This approach effectively avoids contrast-related complications and demonstrates favorable short-term outcomes. However, larger-scale, long-term follow-up studies are needed to further confirm its long-term efficacy and safety.

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) serves as a pivotal biomarker in clinical contexts, enabling the precise assessment of an individual's risk for atherosclerosis and the development of metabolic diseases, particularly diabetes mellitus. Dyslipidemia is strongly associated with the development of several psychiatric disorders. The aim of this study was to explore the association between NHHR and the risk of developing depression in a middle-aged and elderly population from a community in Beijing, China.

We conducted a cross-sectional study using data from 764 questionnaires collected in a community in Beijing, China in 2019. The CESD-10 questionnaire was used to evaluate depression. A multivariable logistic regression model and a restricted cubic spline (RCS) model were applied to investigate the association between NHHR and depression risk. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results.

A total of 152 individuals were diagnosed with depression in this study. After adjusting for covariates, higher NHHR was significantly associated with an elevated risk of depression (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.24~2.12, P<0.001). Compared with the reference group with the lowest NHHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustments (OR: 1.84, 95%CI: 1.09–3.13, P=0.009). A linear dose-response relationship existed between NHHR and depression risk (P=0.157). The results were robust in subgroup and sensitivity analyses.

Higher NHHR (either as a continuous or categorical variable) is significantly associated with a higher risk of depression. Further research on dyslipidemia will aid in the diagnosis and treatment of depression.

To investigate the incidence and related influencing factors of postoperative acute heart failure in patients with gynecological malignant tumors, in order to prevent and reduce the occurrence of postoperative acute heart failure (AHF), thereby improving the therapeutic effect and prognosis of these patients.

A retrospective analysis was performed on the clinical data of gynecological malignant tumor patients who were hospitalized and underwent surgery at the Second Hospital of Hebei Medical University from January 2021 to December 2023, including age, body mass index (BMI), medical history, and auxiliary examination results after admission: white blood cell count (WBC), hemoglobin (HGB), platelet count (PLT), D-dimer, alanine aminotransferase (ALT), total bilirubin (TBil), creatinine (Cr), left ventricular ejection fraction (LVEF), surgical duration, intraoperative blood loss, postoperative day 1 fluid replacement volume, and postoperative day 1 urine volume. According to whether AHF occurred from postoperative to discharge, the patients were divided into an AHF group and a non-AHF group, and the differences in the above indicators between the two groups were compared.

Among the 1049 patients included, 100 had postoperative AHF, with an incidence rate of 9.53%. Specifically, the incidence rate of postoperative AHF was 8.67% for cervical cancer patients, 11.71% for ovarian cancer patients, 9.04% for endometrial cancer patients, and 11.1% for other gynecological malignant tumors. There were significant differences between the AHF group and the non-AHF group in BMI, hypertension, diabetes, D-dimer, LVEF, operation duration, intraoperative blood loss, and fluid replacement volume on the first day after operation (P<0.05). The duration of surgery and the amount of fluid replenished on the first day after surgery were identified to be independent risk factors for AHF after gynecological malignant tumor surgery (P<0.05). With respective cutoff values of 4.25 and 2275, the area under the ROC curve values of the duration of surgery and the amount of fluid replacement on the first day after surgery for predicting AHF were 0.657 and 0.730, respectively, with cutoff values of 4.25 and 2275.

AHF is a common postoperative complication in patients with gynecological malignancies. Patients with gynecological malignancies with a high BMI, diabetes, hypertension, high D-dimer, low LVEF, long operation time, excessive intraoperative blood loss, and excessive fluid replacement on the first day after operation tend to develop postoperative AHF. Accurate preoperative evaluation, paying attention to the management of patients with a high BMI, hypertension, diabetes, high D-dimer, and low LVEF, shortening the length of surgery, reducing intraoperative bleeding, and adjusting the amount of postoperative fluid replacement can reduce the risk of AHF, thus improving the therapeutic effect and prognosis of such patients.

To investigate the clinical characteristics of children with tic disorder (TD) complicated by respiratory tract infection and identify the risk factors for tic symptom aggravation, in order to provide reference and help for clinical treatment of this condition.

A total of 153 children with tic disorder complicated by respiratory tract infection, who were treated in the pediatric tic specialist clinic of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from December 2014 to September 2024, were retrospectively selected. They were divided into two groups according to whether the tic symptoms were aggravated. The clinical characteristics between the two groups were compared, and the risk factors for tic symptom aggravation were identified by univariate analysis.

The main manifestations of respiratory tract infection in the 153 children with tic disorder were fever, cough, and expectoration. After respiratory tract infection, tic symptoms were aggravated in 94 cases (61.44%) and were not in 59 (38.56%). Head and face tic symptoms were most commonly aggravated, followed by vocal symptoms, and the symptoms of limbs and trunk were the least aggravated. Univariate analysis showed that the aggravation of tic symptoms after respiratory tract infection was related to gender, history of allergic diseases, whether there is vocal tic before infection, and whether there is Yinqiaosan in the prescription before infection. The results of multivariate logistic regression analysis suggested that the model failed to identify significant independent risk factors.

Male gender, history of allergic disease, vocal tic before infection, and no use of Yinqiaosan powder in the prescription before infection are risk factors for aggravation of tic symptoms after respiratory tract infection. In seasons with a high incidence of respiratory tract infection, Yinqiaosan powder can be prophylactically used in traditional Chinese medicine prescriptions to reduce the aggravation of tic symptoms.

To evaluate the clinical efficacy of the immunocolloidal gold technique (ICGT), near-infrared autofluorescence imaging (NIRAF), and visual recognition in the intraoperative identification and preservation of parathyroid glands (PTGs).

A total of 227 patients undergoing thyroid surgery at Hefei Second People's Hospital from February 2020 to December 2021 were enrolled and divided into three groups based on the parathyroid identification method used: visual recognition group (n=73), NIRAF group (n=76), and ICGT group (n=78). The differences in intraoperative PTG identification, trends in parathyroid hormone (PTH) and serum calcium levels, and postoperative complications were compared among the groups.

In the visual recognition group, 106 suspected PTG samples were collected from 73 patients. The method demonstrated a specificity of 44%, sensitivity of 82.7%, misdiagnosis rate of 56%, and accuracy of 73.6%. In the NIRAF group, 118 samples were obtained from 76 patients, with a specificity of 83.9%, sensitivity of 95.4%, misdiagnosis rate of 16.1%, and accuracy of 92.4%. In the ICGT group, 133 samples were collected from 78 patients, with a specificity of 95.2%, sensitivity of 92.3%, misdiagnosis rate of 4.8%, and accuracy of 93.2%. Compared with visual recognition and NIRAF, ICGT demonstrated superior specificity and accuracy. No significant differences in PTH and serum calcium levels were observed among the three groups preoperatively or at 6 months postoperatively (P>0.05). However, at postoperative days 3 and 5, and at 1 and 3 months, both the ICGT and NIRAF groups exhibited significantly higher PTH and calcium levels than the visual recognition group (P<0.05), though there was no significant difference between ICGT and NIRAF (P>0.05). The incidence of postoperative hypocalcemia was 24.7% in the visual recognition group, 10.5% in the NIRAF group, and 7.7% in the ICGT group, with the visual group showing a significantly higher rate (P<0.05). The incidence of permanent hypoparathyroidism was 2.7% in the visual group, 0 in the NIRAF group, and 0 in the ICGT group, with no significant intergroup difference (P>0.05).

ICGT demonstrates high specificity and accuracy in identifying PTGs during thyroidectomy, effectively reducing postoperative complications and showing strong clinical value in preserving parathyroid function.

To compare the difference in long-term efficacy between injection therapy and other non-injection therapy for the treatment of complete rectal prolapse.

A retrospective cohort study was conducted to include 180 patients with complete rectal prolapse who were treated with Xiaozhiling injection therapy (116 patients) versus non-injection therapy (64 patients) at Guang'anmen Hospital of the China Academy of Traditional Chinese Medicine from January 1, 2013 to June 30, 2024. Statistical analyese were performed using the R and Fengrui statistical software, with two consecutive survival analysis models constructed to compare patients with different treatment modalities for overall recurrence rate, cumulative recurrence-free survival rate, and postoperative distant recurrence.

The recurrence rate was lower for non-injection therapy (28.1%) than for injection therapy (42.2%). In the unadjusted model, hazard ratio (HR) was 1.34 for non-injection therapy, while it was 1.34 after adjusting for age and sex (model 1), and 1.35 after further adjusting for disease duration and prolapse length (model 2) (0.62~2.96, P=0.451). All models showed that the risk of recurrence associated with injection therapy was not significantly different from that with non-injection therapy, and the cumulative recurrence-free survival analysis was consistent with the results of the multi-factorial analysis.

Despite numerically lower recurrence rates with non-injection therapy, the effect of treatment modality (injection therapy vs. non-injection therapy) on the risk of recurrence was not statistically significant after adjusting for age, sex, duration of disease, and length of prolapse, suggesting that the choice of treatment modality is not a central factor in independently predicting recurrence.

The cardiovascular, renal, and cerebrovascular protective properties as well as metabolic benefits of SGLT2 inhibitors have been well established. However, the potential association between SGLT2 inhibitor treatment and the risk of kidney stones remains an area under investigation and discussion.

This study conducted a systematic search of PubMed, Embase, Cochrane Library, CNKI, and other Chinese and English databases (up to February 2025) and included 10 eligible studies involving 13,430,554 patients. A meta-analysis was performed to compare the risk of kidney stones between the SGLT-2 inhibitor group and the control group.

The results showed that the incidence of kidney stones in the SGLT-2 inhibitor group was significantly lower than that of the control group (odds ratio [OR]=0.68, 95% confidence interval [CI]: 0.57~0.82, P<0.01). Subgroup analysis further indicated that compared with the placebo group (OR=0.71, 95%CI: 0.56~0.90, P<0.01), the GLP-1RA group (OR=0.74, 95%CI: 0.57~0.97, P=0.03), and the DPP-4i group (OR=0.61, 95%CI: 0.40~0.95, P=0.03), SGLT-2 inhibitors were associated with a lower risk of kidney stones. Sensitivity analysis and publication bias tests supported the robustness of the results.

This study suggests that SGLT-2 inhibitors may reduce the risk of kidney stones, which has important implications for clinical practice in diabetic patients with hyperuricemia or a history of kidney stones. Future prospective studies are needed to verify the results, and the safety of their clinical application deserves further attention.

The rapid and precise perfusion assessment of acute ischemic stroke is of paramount significance for treatment guidance and prognosis evaluation. With the continuous progress of imaging technologies, multi-delay pseudocontinuous arterial spin labeling (md-ASL), a non-invasive and radiation-free perfusion imaging technique, has increasingly drawn attention. This technique can provide key parameters such as cerebral blood flow (CBF) and arterial transit time (ATT), which helps to identify the ischemic penumbra and predict the evolution of lesions. However, although numerous studies have investigated the application of md-ASL in acute ischemic stroke (AIS), problems such as insufficient parameter standardization and limited clinical applicability still remain. Therefore, this paper aims to comprehensively summarize the latest research findings on md-ASL in the field of perfusion assessment for acute ischemic stroke, and conduct an in-depth analysis of the relationships between CBF and ATT parameters, the core and penumbra regions of the ischemic area, and clinical outcomes. Meanwhile, the paper explores the clinical application value of md-ASL under various recanalization conditions and its future development trends.

Septic cardiomyopathy is a form of reversible myocardial injury caused by sepsis, contributing significantly to the mortality associated with sepsis. The pathophysiological mechanisms underlying septic cardiomyopathy are intricate, involving a multitude of factors such as cytokine release, myocardial cell injury or death, mitochondrial dysfunction, disrupted calcium homeostasis, and abnormal nitric oxide synthesis. As a complex clinical syndrome, the management of septic cardiomyopathy requires a thorough understanding of these pathophysiological processes and the application of multifaceted therapeutic strategies. With ongoing research advancements and the accumulation of clinical insights, enhancements in the diagnosis and treatment of septic cardiomyopathy are expected, potentially leading to a decrease in sepsis-related mortality. This article aims to review the current research developments regarding the pathophysiological mechanisms, clinical presentations, diagnostic approaches, and therapeutic interventions for septic cardiomyopathy.

Overweight and obesity are characterized by an imbalance where energy intake exceeds energy expenditure. Due to the high prevalence and numerous complications, they are impacting the global public health. Dieting, exercise, medication, and surgery are common therapeutic approaches, yet all have their limitations. Currently, endoscopic gastric injection of botulinum toxin type A for weight reduction has gained attention. In this paper, we review the advancements in this technique, with an aim to provide a basis for its appropriate application.

Bladder cancer is a common malignant tumor of the urinary system, and immunotherapy has brought new opportunities for its treatment. This article synthesizes the relevant literature to elaborate on various methods of immunotherapy for bladder cancer, including immune checkpoint inhibitor therapy and bacille Calmette-Guérin (BCG) intravesical perfusion therapy. By analyzing their curative effects, related biomarkers, and safety profiles, this paper discusses the challenges faced by immunotherapy and its future development directions, aiming to provide a comprehensive reference for immunotherapy of bladder cancer and promote advancements in clinical practice.