Cancer rehabilitation has become a critical component in improving patients' quality of life，reducing treatment side effects，and promoting functional recovery.This consensus，grounded in the latest global research and clinical practices，establishes systematic assessment criteria and intervention strategies for cancer rehabilitation.The consensus was developed using the Delphi method，with a multidisciplinary expert panel integrating evidence from international guidelines，systematic reviews，randomized controlled trials，and expert opinions to formulate scientifically robust and clinically feasible rehabilitation strategies.The consensus defines the target population and objectives of cancer rehabilitation，emphasizing that rehabilitation should span the entire treatment continuum，including prehabilitation before treatment，rehabilitation interventions during therapy，and long-term recovery.For assessments，the consensus recommends adopting the International Classification of Functioning，Disability，and Health framework to comprehensively evaluate patients' body structure/function，activity and participation levels，and environmental factors，alongside proposing standardized assessment tools.For interventions，the consensus outlines “Five Core Prescriptions for Cancer Rehabilitation”： exercise，nutrition，medication，psychological support，and palliative care.Additionally，it highlights the pivotal role of multidisciplinary teams in cancer rehabilitation，advocating for dynamic assessment and communication mechanisms to optimize rehabilitation protocols and enhance outcomes.
Subcutaneous emphysema is a common complication following lung cancer surgery，influenced by factors such as disease type，surgical technique，incision selection，and suture quality.Extensive subcutaneous emphysema could lead to dyspnea，dysphagia，and localized abdominal pain，potentially progressing to respiratory failure in severe cases.The nursing care of patients with subcutaneous emphysema is a crucial aspect of clinical management，positively impacting their quality of life.Currently，there is a lack of expert consensus or guidelines for the nursing of patients with subcutaneous emphysema after lung cancer surgery.To further standardize the management of patients with subcutaneous emphysema after lung cancer surgery，the Lung Cancer Case Management Professional Committee of the Guangdong Nursing Association and the Lung Oncology Branch of the Guangdong Medical Association jointly organized experts from related fields to formulate an expert consensus on nursing standards for patients with subcutaneous emphysema after lung cancer surgery，focusing on the occurrence mechanism，grading standards，prevention and monitoring，intervention，and nursing of patients with subcutaneous emphysema after lung cancer surgery，aiming to provide scientific and systematic guidance for clinical nursing practice.
To identify the risk factors for delayed recovery after surgery in infants with non-restrictive ventricular septal defects （VSD），in order to provide evidence for early intervention and optimization of treatment strategies in clinical practice.
Methods
This study included 86 infants with nonrestrictive VSD who underwent surgery at the Department of Cardiovascular Surgery of Capital Institute of Pediatrics between October 2016 and January 2025.The infants were divided into two groups based on whether their postoperative ICU stay exceeded the median duration （4 days）： normal recovery group（ICU stay≤4 days，n=49） and delayed recovery group （ICU stay＞4 days，n=37）.Univariate analysis was performed on the general data as well as preoperative，intraoperative，and postoperative clinical indicators of both groups，and variables with statistical significance were included in a binary logistic regression analysis to identify the risk factors for delayed recovery after surgery.
Results
Significant differences between the two groups were found in terms of weight，admission heart rate，respiratory status，N-terminal pro B-type natriuretic peptide，heart function classification，preoperative pulmonary hypertension，and postoperative intubation time （P＜0.05）.Binary logistic regression analysis revealed that the regression coefficients for admission respiratory status，preoperative pulmonary hypertension，and postoperative intubation time were 2.923，0.053，and 0.071，respectively，all showing statistical significance （P＜0.05），and the odds ratios were 6.84，1.055，and 1.073，respectively.
Conclusion
Preoperative pulmonary hypertension，admission respiratory status，and postoperative intubation time are independent risk factors for delayed recovery in infants with non-restrictive VSD.Early intervention and optimization of treatment are crucial in clinical practice to reduce the occurrence of delayed recovery and improve treatment outcomes.
To analyze the pathogen distribution and risk factors for peritoneal dialysis（PD）-associated peritonitis （PDAP） in patients with end-stage renal disease （ESRD）.
Methods
Clinical data of 231 ESRD patients undergoing PD at Ansteel Group General Hospital from January 2019 to January 2024 were retrospectively collected.Biochemical indicators and comorbidities were compared between the PDAP group and the control group，with risk factors identified using logistic regression.
Results
Among the 231 PD patients included，128 episodes of PDAP occurred.Gram-positive bacteria，predominantly Staphylococcus epidermidis，accounted for 75 cases （58.59%）.Gram-negative bacteria，primarily Escherichia coli，caused 32 cases （25.0%）.Other pathogens included Stenotrophomonas maltophilia （2 cases，1.56%） and fungi （3 cases，2.34%）.Risk factors identified for PDAP included hypoalbuminemia，anemia，comorbid diabetes，and hypokalemia （P＜0.05）.
Conclusion
The primary pathogens of PDAP are Staphylococcus epidermidis and Escherichia coli.Key risk factors for PDAP include comorbid diabetes，hypoalbuminemia，anemia，and hypokalemia.
To investigate the association between serum 25（OH）D levels and islet β-cell function in type 2 diabetes mellitus （T2DM） patients，and assess the therapeutic effects of vitamin D （VD） supplementation on pancreatic islet function in VD-deficient T2DM subjects，with the objective of establishing an evidence-based treatment approach.
Methods
A total of 440 patients with T2DM who met the inclusion and exclusion criteria were selected from the Department of Endocrinology，The First Affiliated Hospital of Xinjiang Medical University.General clinical data and biochemical parameters were collected，and the 2-hour C-peptide to fasting C-peptide ratio （2hC-P/C-P） was calculated to assess pancreatic islet function.The patients were stratified into three groups based on VD levels，and differences in clinical indicators among the groups were compared，followed by correlation analysis.Additionally，48 T2DM patients were followed after VD supplementation to evaluate changes in islet function before and after intervention.
Results
Among the three groups with varying VD levels，fasting blood glucose （FBG），2-hour postprandial blood glucose （2hPG），and hemoglobin A1c （HbA1c） progressively decreased，while 2hC-P/C-P increased with higher VD levels，with statistically significant differences （P＜0.05）.Both Spearman correlation analysis and partial correlation analysis demonstrated significant associations between 25（OH）D levels and islet β-cell function as well as glycemic control （P＜0.05）.After VD supplementation，FBG，2hPG，and HbA1c decreased，whereas 2hC-P/C-P increased compared to baseline，with all changes being statistically significant （P＜0.05）.
Conclusion
VD levels influence islet β-cell function in T2DM patients.Supplementation with VD in VD-deficient individuals may improve β-cell function and glycemic control.Therefore，routine screening of VD levels should be incorporated into T2DM management，and VD supplementation should be considered alongside conventional glucose-lowering therapies.
A scientific and standardized system is the foundation for the efficient operation of hospitals and an important guarantee for achieving modernization，refinement，and sustainable development of hospital governance.This paper discusses the application of the PDCA theory to hospital system construction，and provides a detailed introduction of the practice in deploying and promoting hospital system construction in the four stages of “planning，implementation，inspection，and feedback”.Discussions are conducted from the perspectives of “connotation construction，framework system，operational guarantee，and cultural construction” to explore the practical significance of system construction in enhancing hospital governance capacity.
Cerebrovascular disease is one of the major threats to global health.Early accurate diagnosis and treatment decisions are crucial for improving patient outcomes，but traditional imaging evaluation methods have many limitations.In recent years，artificial intelligence （AI） has significantly enhanced the efficiency and accuracy of cerebrovascular disease imaging analysis through data preprocessing，automatic feature extraction，and the construction of deep learning models.This paper systematically reviews the latest advancements in AI technology for cerebrovascular disease imaging evaluation，focusing on its clinical application in detecting acute ischemic stroke，hematoma，aneurysm，and microbleeding.The current challenges and future directions are also discussed.
The chronic kidney disease （CKD） population in China continues to grow，accompanied by an increasing number of CKD-related pruritus cases.This condition has emerged as a key clinical concern due to its marked impairment of life quality and elevated mortality risk.However，its pathological mechanisms and therapeutic options remain poorly understood.This article systematically reviews the pathogenesis and current therapeutic approaches for this condition，aiming to enhance clinical outcomes and improve patients' quality of life.
This review aims to summarize the role of COL10A1 in cancer biology，particularly its impact on tumor progression，immune modulation，and its potential as a therapeutic target.The paper also highlights some gaps in current research，especially in terms of understanding the exact molecular mechanisms linking COL10A1 to various signaling pathways and immune responses.Future research，especially large-scale clinical trials，is urgently needed to validate the value of COL10A1 as a reliable cancer prognostic and therapeutic biomarker.By targeting COL10A1 or its associated pathways，new therapeutic strategies could be developed to improve cancer treatment outcomes and enhance the patient's immune response.
S100B is a calcium binding protein，mainly secreted by astrocytes，Schwann cells，and oligodendrocytes in the nervous system.It is commonly used clinically to evaluate brain injury and its severity.As a damage-associated molecular pattern protein，S100B can also be secreted in cardiomyocytes，causing damage to the endothelium of cardiac blood vessels，inducing apoptosis of cardiomyocytes，disrupting calcium ion homeostasis in cardiomyocytes，inhibiting the intrinsic nervous system of the heart，leading to myocardial injury and ventricular remodeling，and inducing cardiovascular events.This article reviews the progress in the research of S100B protein in cardiovascular diseases，opening up the perspective that S100B protein may be considered as a diagnostic and therapeutic target for cardiovascular diseases.
Chronic hepatitis B virus （HBV） infection is a significant global public health issue，severely impacting patients' quality of life and increasing the risk of liver cirrhosis and hepatocellular carcinoma.In recent years，functional cure has emerged as a major research priority，particularly with the combined application of small interfering RNA （siRNA） technology and Toll-like receptor 8 （TLR8） agonists.This article reviews the latest advancements in the field of functional cure for HBV infection，with a focus on analyzing the synergistic mechanisms between siRNAs （e.g.，VIR-2218） and TLR8 agonists.Through an indepth examination of the existing literature，this paper outlines the potential advantages and prospects of these two therapeutic strategies in HBV clearance，especially their interplay in enhancing immune responses and promoting viral eradication，with an aim to provide an important theoretical foundation for subsequent clinical research.
