To investigate the relationship between gastric mucosal atrophy with intestinal metaplasia and chronic gastritis, and to evaluate the therapeutic effect of combined drug therapy on chronic atrophic gastritis with intestinal metaplasia.

One hundred and fourteen patients who were diagnosed with chronic gastritis with atrophy and intestinal metaplasia by endoscopic pathological biopsy at our hospital from February 2014 to September 2015 were randomly divided into two groups: a control group (treated with Weifuchun tablets alone; n=56) and a combination treatment group (treated with Weifuchun tablets combined with compound allantoin and multi-vitamin B tablets; n=58). Six months after treatment, gastroscopic biopsy was performed to assess the degree of mucosal inflammation, atrophy, and intestinal metaplasia. SPSS 20.0 software was used for statistical analysis.

After treatment, gastroscopic biopsy revealed that atrophy was reversed in ten (17.24%) cases in the combination treatment group and three (5.36%) cases in the control group, and the cure rate of atrophy was significantly higher in the combination treatment group than in the control group (χ²=3.983, P=0.046); and that intestinal metaplasia was reversed in 20 (34.48%) cases in the combination treatment group and eight (14.29%) cases in the control group, and the cure rate of intestinal metaplasia was significantly higher in the combination treatment group than in the control group (χ²=6.272, P=0.012). After treatment, the degree of atrophy and intestinal metaplasia in the combination treatment group was significantly lower than that of the control group (χ²=14.856, P=0.002; χ²=11.469, P=0.009). The degree of atrophy and intestinal metaplasia in the combination treatment group was significantly reduced after treatment compared with before treatment (χ²=41.970, P=0.000; χ²=32.253, P=0.000). The degree of intestinal metaplasia in the control group was significantly reduced after treatment compared with before treatment (χ²=8.949, P=0.03), but atrophy showed no significant improvement (χ²=4.308, P=0.230).

Appropriate drug therapy is useful to treat atrophy and intestinal metaplasia in chronic gastritis. Combined Weifuchun tablets, multi-vitamin B tablets, and compound allantoin have significantly better therapeutic effect than Weifuchun tablets alone, especially in some cases.