Association between neovascular glaucoma and platelets

doi:10.3877/cma.j.issn.1674-0785.2017.14.003

Abstract

Abstract:

Objective

To investigate the change of platelets in neovascular glaucoma secondary to diabetic retinopathy and analyze its clinical significance.

Methods

This retrospective, case-control study involved a total of 288 subjects enrolled from January 2010 to December 2016 at Taian Central Hospital, including patients with NVG secondary to diabetic retinopathy (n=88), diabetes mellitus without retinopathy (n=104), and healthy individuals (n=96). The data of all the subjects were collected. NVG was divided into two categories: open-angle NVG and close-angle NVG. Independent samples t-test, one-way ANOVA, and multiple logistic regression analysis were used for statistical analysis in this study.

Results

There was no statistical difference in mean age or gender among the three groups. The mean levels of platelet distribution width (PDW), plateletcrit (PCT), and mean platelet volume (MPV) were higher in the NVG group compared with the control group [(16.14 ± 1.54) fl vs (13.69 ± 2.99) fl, (0.223 ± 0.059) % vs (0.196 ± 0.043) %, (10.69 ± 1.53) fl vs (9.78 ± 0.92) fl, respectively]. The mean level of PDW was higher in the NVG group compared with the diabetes mellitus group [(16.14 ± 1.54) fl vs (13.89 ± 3.35) fl]. There was no significant difference between the open-angle NVG and close-angle NVG groups. Multiple logistic regression analysis revealed that PDW (OR=1.519, 95% CI: 1.244-1.854, P<0.001) and MPV (OR=3.066, 95% CI: 1.156-8.134, P=0.024) were independent risk factors for NVG.

Conclusion

PDW and MPV are associated with NVG, suggesting that platelets might play an important role in the development of NVG.

Key words: Neovascular glaucoma, Platelets, Diabetic retinopathy, Correlation study

Yongjun Liu, Qian Xu, Jintao Mao, Tian Wang, Tong Lu, Xiaohan Yang, Qiang Chen. Association between neovascular glaucoma and platelets[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(14): 2023-2027.

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Figures/Tables 4

References 16

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组别	例数	年龄（岁，±s）	性别（男/女，例）	BMI（kg/m²，±s）	高血压[例（%）]
NVG	88	54.13±10.81	51/37	21.21±6.69	38（43.18）
糖尿病组	104	55.08±15.15	61/43	22.41±2.12	44（42.31）
对照组	96	54.88±12.99	50/46	21.61±2.96	26（27.08）
统计值	?	t=0.135	χ²=1.025	t=0.538	χ²=2.235
P值	?	0.874	0.599	0.586	0.327

组别	例数	年龄（岁，±s）	性别（男/女，例）	BMI（kg/m²，±s）	高血压[例（%）]
NVG	88	54.13±10.81	51/37	21.21±6.69	38（43.18）
糖尿病组	104	55.08±15.15	61/43	22.41±2.12	44（42.31）
对照组	96	54.88±12.99	50/46	21.61±2.96	26（27.08）
统计值	?	t=0.135	χ²=1.025	t=0.538	χ²=2.235
P值	?	0.874	0.599	0.586	0.327

组别	PLT（×10⁹/L）	PDW（?fl?）	PCT（%）	MPV（?fl?）
NVG	211.26±62.96	16.14±1.54	0.223±0.059	10.69±1.53
糖尿病组	202.92±79.39	13.89±3.35	0.220±0.077	10.40±10.88
对照组	199.95±53.58	13.69±2.99	0.196±0.043	9.78±0.92
F值	0.601	19.060	3.695	12.658
P值	0.549	＜0.001	0.049	0.002
t₁值	0.744	5.672	0.309	1.495
P₁值	0.458	＜0.001	0.758	0.137
t₂值	1.203	6.416	2.968	4.503
P₂值	0.231	＜0.001	0.004	＜0.001
t₃值	0.286	0.403	2.257	4.251
P₃值	0.775	0.687	0.025	＜0.001

组别	PLT（×10⁹/L）	PDW（?fl?）	PCT（%）	MPV（?fl?）
NVG	211.26±62.96	16.14±1.54	0.223±0.059	10.69±1.53
糖尿病组	202.92±79.39	13.89±3.35	0.220±0.077	10.40±10.88
对照组	199.95±53.58	13.69±2.99	0.196±0.043	9.78±0.92
F值	0.601	19.060	3.695	12.658
P值	0.549	＜0.001	0.049	0.002
t₁值	0.744	5.672	0.309	1.495
P₁值	0.458	＜0.001	0.758	0.137
t₂值	1.203	6.416	2.968	4.503
P₂值	0.231	＜0.001	0.004	＜0.001
t₃值	0.286	0.403	2.257	4.251
P₃值	0.775	0.687	0.025	＜0.001

组别	例数	年龄（岁）	性别（男性/女性，例）	高血压[例（%）]	BMI（kg/m²）	PLT（×10⁹/L）	PDW（?fl?）
开角型NVG	39	52.87±10.94	21/18	15（38.46）	20.83±7.26	200.13±50.36	16.34±1.46
闭角型NVG	49	55.12±10.71	30/19	23（46.94）	21.49±6.35	213.84±68.57	15.96±1.84
统计值	?	t=0.97	χ²=0.485	χ²=0.636	t=0.356	t=1.044	t=1.061
P值	?	0.335	0.486	0.425	0.723	0.299	0.292
组别	例数	PCT（%）	MPV（?fl?）	IOP（mmHg）	VCDR	MD（dB）	MS（dB）
开角型NVG	39	0.215±0.054	10.82±1.64	37.84±13.66	0.59±0.17	26.77±1.02	1.07±1.01
闭角型NVG	49	0.222±0.063	10.49±1.46	38.99±13.21	0.57±0.21	25.29±1.82	2.25±1.54
统计值	?	t=0.491	t=0.982	t=0.398	t=0.328	t=2.352	t=2.146
P值	?	0.625	0.329	0.692	0.745	0.027	0.042

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