Relationship between stromal cell-derived factor-1 and chronic complications of diabetes

doi:10.3877/cma.j.issn.1674-0785.2017.14.006

Abstract

Abstract:

Diabetic chronic complications have high morbidity and mortality, but their pathogenesis is not completely clear yet. In recent years, it is recognized that stromal cell-derived factor-1 (SDF-1) is closely related to the development and progression of diabetic chronic complications. As a chemokine, SDF-1 binds to its specific receptor and thus exerts chemotactic effects on the infiltration of inflammatory cells, induces the differentiation of endothelial progenitor cells, and participates in new blood vessel formation and nerve repair. It has been found that SDF-1 plays a vital role in the development of chronic diabetic complications. The purpose of this paper is to review the recent advances in the understanding of the relationship between SDF-1 and diabetic chronic complications in order to provide a new strategy for the treatment of diabetic chronic complications.

Key words: Stromal cell derived factor-1, Diabetic microvascular complication, Diabetic macrovascular complication, Diabetic neuropathy

Wei Pang, Rui Han. Relationship between stromal cell-derived factor-1 and chronic complications of diabetes[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(14): 2038-2041.

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