Abstract:
Objective To detect the expression of caudal homeobox gene 2 (CDX2) and Topoisomerase Ⅱ (TopoⅡ) in stage Ⅲ colon cancer in elderly patients and to analyze their relationship with the prognosis of the patients.
Methods A retrospective study was performed of the clinical data for 186 elderly patients with stage Ⅲ colon cancer (≥70 years old) who received radical surgery at Renji Hospital from January 2005 to December 2009. All the patients were followed after surgery, and the relationship between CDX2 and TopoⅡ expression and prognosis was analyzed.
Results The positive expression rates of CDX2 and TopoII in colon cancer were 50.0% and 55.9%, respectively. The 5-year disease-free survival rate was significantly higher in CDX2-positive patients than in CDX2-negative patients, and in TopoⅡ-negative patients than in TopoⅡ-positive patients (P<0.05). The 5-year disease-free survival rate was significantly higher in CDX2-positive and TopoⅡ-negative cases than in CDX2-positive and TopoⅡ-positive cases (P<0.05).
Conclusion The expression of CDX2 and TopoⅡ is closely related to the invasion and metastasis of colon cancer in elderly patients. Detection of CDX2 and TopoⅡ expression is helpful for evaluating the prognosis of elderly patients with colon cancer.
Key words:
Elderly,
Stage Ⅲ colon cancer,
CDX2,
Topoisomerase Ⅱ
Chunbo Yu, Liang Huang, Shufang Tao, Weizhong Yan, Dong Li, Qing Xu, Jinxian Chen. Clinical significance of expression of CDX2 and Topo Ⅱ in stage Ⅲ colon cancer in elderly patients[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(15): 2073-2076.