Urinary tract infection (UTI) is one of the most common infectious diseases in the world, and the UTI rate ranks second only to that of respiratory infection. Postmenopausal women are a special population, and UTI in this population presents the features of persistence and high recurrence. So far, there have been few effective strategies available for the prevention and treatment of UTI in postmenopausal women. This paper, based on the literature, discusses the effectiveness and safety of estrogen supplementation, lactobacilli, and antibiotics, alone or in combination, in the prevention and treatment of UTI in postmenopausal women. At present, antibiotics and estrogen are the main treatments for preventing and treating UTI in postmenopausal women. However, new clinical drugs or experimental drugs are under development and trial, which may improve the treatment of UTI in postmenopausal women.