Molecular mechanisms of autophagy in cancers

doi:10.3877/cma.j.issn.1674-0785.2018.03.009

Abstract

Abstract:

Autophagy aims to capture and degrade intracellular proteins and organelles, which is induced by starvation and recycles intracellular components to sustain metabolism and survival. Autophagy maintains homeostasis by controlling protein and organelle quality and quantity. Many diseases can be attributed to dysfunctional autophagy. The role of autophagy in cancer is determined by many factors, and autophagy can be neutral, tumor-suppressive, or tumor-promoting in different contexts in cancers. Here we summarize the molecular mechanisms involved in autophagy in cancers and review the potential treatment targets for cancers.

Key words: Autophagy, Cancer, Molecular mechanism

Tingting Fu, Shanyong Yi, Ling Zhao. Molecular mechanisms of autophagy in cancers[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(03): 164-167.

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URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2018.03.009

https://zhlcyszz.cma-cmc.com.cn/EN/Y2018/V12/I03/164

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