Clinical value of 18F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen

doi:10.3877/cma.j.issn.1674-0785.2019.11.005

Abstract

Abstract:

Objective

To explore the value of 18-fluorine flurodeoxyglucose (¹⁸F-FDG) positron-emission tomography (PET)/computed tomography (CT) in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen (CEA).

Methods

Clinical data of 60 cases of colorectal cancer, including PET/CT, pathological, and follow-up results, were analyzed retrospectively.

Results

There were 50 ¹⁸F-FDG PET/CT positive and 10 ¹⁸F-FDG PET/CT negative cases, including 1 false positive and 3 false negative cases. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ¹⁸F-FDG PET/CT in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum CEA were 94.2%(49/52), 87.5% (7/8), 98.0% (49/50), 70.0% (7/10), and 93.3% (56/60), respectively.

Conclusion

¹⁸F-FDG PET/CT has high clinical value in postoperative colorectal cancer patients with elevated serum CEA, and it has a high sensitivity, specificity, and accuracy in the detection of recurrence and metastasis.

Key words: Colorectal neoplasms, Recurrence, Neoplasm metastasis, Positron-emission tomography, Tomography, X-ray computed, Carcinoembryonic antigen

Xinfeng Lin, Nan Li, Fei Wang, Wei Zhao, Zhi Yang. Clinical value of ¹⁸F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(11): 822-827.

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Figures/Tables 6

References 30

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项目		相关数据
性别（例）		?
?	男	41
?	女	19
中位年龄（年龄范围，岁）		59（37~84）
病灶部位（例）		?
?	结肠	28
?	直肠	32
病理类型（例）		?
?	黏液腺癌	2
?	非黏液腺癌	58
CEA值（±s，μg/L）		128.6±373.5
CEA合并CA199升高（例）		25
确诊手段（例）		?
?	再次手术	15
?	肠镜	2
?	穿刺活检	3
?	多种影像学检查	13
?	随访	27

项目		相关数据
性别（例）		?
?	男	41
?	女	19
中位年龄（年龄范围，岁）		59（37~84）
病灶部位（例）		?
?	结肠	28
?	直肠	32
病理类型（例）		?
?	黏液腺癌	2
?	非黏液腺癌	58
CEA值（±s，μg/L）		128.6±373.5
CEA合并CA199升高（例）		25
确诊手段（例）		?
?	再次手术	15
?	肠镜	2
?	穿刺活检	3
?	多种影像学检查	13
?	随访	27

¹⁸F-FDG PET/CT检查结果	最终诊断		合计
¹⁸F-FDG PET/CT检查结果	阳性	阴性	合计
阳性	49	1	50
阴性	3	7	10
合计	52	8	60

¹⁸F-FDG PET/CT检查结果	最终诊断		合计
¹⁸F-FDG PET/CT检查结果	阳性	阴性	合计
阳性	49	1	50
阴性	3	7	10
合计	52	8	60

复发/转移部位	例数	占比（%）
局部复发	12	24.5（12/49）
腹膜转移	17	34.7（17/49）
全身淋巴结转移	13	26.5（13/49）
肝转移	25	51.0（25/49）
肺转移	22	44.9（22/49）
其他（骨、脑、肾上腺等）转移	11	22.4（11/49）

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