Meta-analysis of diagnostic value of T-SPOT.TB test and tuberculin skin test in tuberculous disease in children

doi:10.3877/cma.j.issn.1674-0785.2020.02.011

Abstract

Abstract:

Objective

To systematically evaluate the diagnostic value of T-SPOT.TB test and tuberculin skin test (TST) in tuberculous disease in children.

Methods

Studies on the diagnosis of tuberculous disease in children by different detection methods, which were published before October 31, 2018, were searched in databases including CNKI, Wanfang Data, PubMed, and EMBASE. The positive rates of different test methods for children with tuberculous disease were collected, and methodology quality evaluation and data extraction were performed. Meta-Disc 1.4, RevMan 5.3, and Stata 15.1 were used to carry out the meta-analysis. Meta-disc1.4 software was used for sensitivity and specificity analysis, and the summary receiver operating characteristic (SROC) curves were plotted. QUADAS-2 in RevMan 5.3 software was used to evaluate the quality of the articles. Stata 15.1 was used to test publication bias and Deeks funnel plot was drawn.

Results

Fifteen studies were included in this study. Meta-analysis showed that the pooled sensitivity and specificity of T-SPOT. TB test were 89% (95%CI: 87%-91%) and 95% (95%CI: 93%-96%), respectively, and those of TST were 66% (95%CI: 63%-70%) and 70% (95%CI: 66%-73%), respectively.

Conclusion

Compared with TST, T-SPOT.TB has a higher sensitivity and specificity and therefore has higher diagnostic value in tuberculous disease in children.

Key words: T-SPOT.TB, Tuberculin skin test, Tuberculosis, Meta-analysis

Qiaopei Chen, Ying Ding. Meta-analysis of diagnostic value of T-SPOT.TB test and tuberculin skin test in tuberculous disease in children[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(02): 129-135.

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Figures/Tables 10

References 28

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