Comprehensive and strict governance of the Party is the political guarantee for the development of the Party and the state in the new era, and is the fundamental follow of exploring the law of Party building in the development of scientific research and innovation. Party building is the fundamental guarantee of scientific research, which determines the direction, depth, and breadth of scientific research. Strengthening Party building in scientific research is an inevitable requirement for implementing the strategy of rejuvenating the country through science and education, strengthening the country through talents and sustainable development, deepening the reform of scientific and technological system, promoting the development of scientific and technological undertakings, and stimulating the vitality of scientific and technological innovation. How to lead scientific research innovation, strengthen the integration of Party building and business, enhance the comprehensive strength of scientific research institutions, improve the confidence and determination of scientific and technological workers in innovation, more widely transform the basic research into productivity, and benefit the mankind are the key issues that Party workers should face in every scientific research institution.