Effects of cardiac plexus ablation combined with low intensity tragus vagus nerve stimulation on electrophysiological characteristics of atrial fibrillation in dogs

doi:10.3877/cma.j.issn.1674-0785.2021.05.011

Abstract

Abstract:

Objective

To study the effect of cardiac ganglion plexus ablation combined with low intensity tragus vagus nerve stimulation on electrophysiological characteristics in a dog model of atrial fibrillation, and to explore the value of tragus vagus nerve stimulation in preventing the recurrence of atrial fibrillation after ablation.

Methods

Twenty-one adult beagle dogs were randomly divided into three groups: RAP group (n=7; 500 times/min rapid atrial pacing), ABL group [n=7; ablation of the right superior ganglion plexus (ARGP) and left superior ganglion plexus (LSGP) + 500 times/min rapid atrial pacing], and LL-ST group (n=7; ARGP and LSGP ablation + low intensity right ear vagus nerve stimulation + 500 times/min rapid atrial pacing). At baseline and 2, 4, 6, 8, 10, 12, 14, and 16 h after pace-making, the inducibility and duration of atrial fibrillation, effective refractory period (ERP), and dispersion effective refractory period(dERP) in different locations of the atrium and pulmonary veins were detected.

Results

(1) Compared with RAP group, the inducibility and duration of atrial fibrillation were significantly reduced in the LL-ST group (P＜0.05); the ERP was significantly prolonged and the dERP was significantly decreased (P＜0.05). (2) Compared with ABL group, the inducibility and duration of atrial fibrillation were significantly reduced in the LL-ST group (P＜0.05); the ERP was significantly prolonged and the dERP was significantly decreased (P＜0.05).

Conclusion

Low intensity right tragus stimulation combined with cardiac ganglion plexus ablation can effectively control the recurrence of atrial fibrillation after ablation.

Key words: Atrial fibrillation, Electrical nerve stimulation, Vagus nerve, Cardiac ganglion plexus, Ablation

Zhi Yang, Feng Zhang, Fuhua Lei, Wenbo Chen, Yuemei Hou. Effects of cardiac plexus ablation combined with low intensity tragus vagus nerve stimulation on electrophysiological characteristics of atrial fibrillation in dogs[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(05): 370-374.

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References 18

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