Study of serum vitamin A and vitamin D level in idiopathic short stature children

doi:10.3877/cma.j.issn.1674-0785.2021.06.008

Abstract

Abstract:

Objective

To compare the difference of serum vitamin A and vitamin D level in idiopathic short stature (ISS) children and normal.

Methods

Data of 158 ISS children (ISS group) in our hospital from May 2018 to May 2020 were analyzed retrospectively, including 86 boys and 72 girls, with an average age of (6.09±2.39) years. The control group consisted of 144 health children of normal height, including 78 boys and 66 girls, with an average age of (6.10±2.89) years. Serum samples of all children were collected, while levels of vitmin A and 25 (OH) D were detected.

Results

The levels of vitamin A [(0.32±0.08) mg/L] and 25 (OH) D [(24.21±7.61) ng/ml] in ISS group were all lower than normal [(0.35±0.08) mg/L, (27.28±7.86) ng/ml], the differences between the two groups had statistical significance (P＜0.01). Vitmin A deficiency rate and marginal vitamin A deficiency rate were statistically significant higher in ISS group (4.43%, 40.51%) than those in the control group (0.69%, 25.00%) (P＜0.01). Vitamin D insufficiency and deficiency rates were statistically significant higher in ISS group (14.56%, 13.29%) than those in the control group (7.64%, 4.86%) (P＜0.01). In this study taken height normal or not as dependent variable, the factors that P＜0.1 in single factor analysis as the independent variable, multi-factor Logistic analysis showed that father's height, loss of appetite and vitamin D deficiency were connected with children's height (P＜0.05).

Conclusion

The serum vitamin A and vitamin D levels are all lower in ISS chliden than in normal. Vitmin A deficiency/marginal deficiency rate and vitamin D insufficiency/deficiency rate are all significant higher in ISS children than in normal. We also find that vitamin D deficiency is connected with short stature of children.Vitamin D supplementation is beneficial for children's height growth.

Key words: Idiopathic short stature, Vitamin A, Vitamin D, 25-hydroxyvitamin D

Hui Wang, Yingwei Bi. Study of serum vitamin A and vitamin D level in idiopathic short stature children[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(06): 445-449.

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Figures/Tables 3

项目	矮身材组（158例）	对照组（144例）	统计值	P值
性别［例（%）］			χ²=0.002	0.963
男	86（54.43）	78（54.17）
女	72（45.57）	66（45.83）
年龄（岁， $x ¯$ ±s）	6.09±2.39	6.10±2.89	t=0.46	0.983
身高（cm， $x ¯$ ±s）	108.24±13.14	120.17±18.46	t=6.41	＜0.001
体质量（kg， $x ¯$ ±s）	18.51±5.81	23.96±10.80	t=5.38	＜0.001
父亲身高（cm， $x ¯$ ±s）	171.05±4.73	172.94±5.13	t=3.34	0.001
母亲身高（cm， $x ¯$ ±s）	158.51±4.66	159.64±5.40	t=1.96	0.052
出生身长（cm， $x ¯$ ±s）	49.14±2.31	49.80±1.79	t=2.09	0.004
出生体质量（g， $x ¯$ ±s）	3047.11±488.61	3242.29±532.62	t=3.32	0.001
早产［例（%）］	19（12.03）	7（4.86）	χ²=4.92	0.027
萌牙时间（月龄， $x ¯$ ±s）	6.59±1.47	6.34±1.42	t=-1.49	0.138
食欲差［例（%）］	103（65.19）	65（45.14）	χ²=12.27	＜0.001
运动少［例（%）］	23（14.56）	11（7.64）	χ²=3.68	0.055
睡眠差［例（%）］	25（15.82）	25（17.36）	χ²=0.83	0.363

项目	矮身材组（158例）	对照组（144例）	统计值	P值
性别［例（%）］			χ²=0.002	0.963
男	86（54.43）	78（54.17）
女	72（45.57）	66（45.83）
年龄（岁， $x ¯$ ±s）	6.09±2.39	6.10±2.89	t=0.46	0.983
身高（cm， $x ¯$ ±s）	108.24±13.14	120.17±18.46	t=6.41	＜0.001
体质量（kg， $x ¯$ ±s）	18.51±5.81	23.96±10.80	t=5.38	＜0.001
父亲身高（cm， $x ¯$ ±s）	171.05±4.73	172.94±5.13	t=3.34	0.001
母亲身高（cm， $x ¯$ ±s）	158.51±4.66	159.64±5.40	t=1.96	0.052
出生身长（cm， $x ¯$ ±s）	49.14±2.31	49.80±1.79	t=2.09	0.004
出生体质量（g， $x ¯$ ±s）	3047.11±488.61	3242.29±532.62	t=3.32	0.001
早产［例（%）］	19（12.03）	7（4.86）	χ²=4.92	0.027
萌牙时间（月龄， $x ¯$ ±s）	6.59±1.47	6.34±1.42	t=-1.49	0.138
食欲差［例（%）］	103（65.19）	65（45.14）	χ²=12.27	＜0.001
运动少［例（%）］	23（14.56）	11（7.64）	χ²=3.68	0.055
睡眠差［例（%）］	25（15.82）	25（17.36）	χ²=0.83	0.363

组别	例数	维生素A				维生素D
组别	例数	血清维生素A水平（mg/L， $x ¯$ ±s）	缺乏［例（%）］	边缘型缺乏［例（%）］	充足［例（%）］	（ng/ml，±s）血清25（OH）D水平	缺乏［例（%）］	不足［例（%）］	充足［例（%）］
矮身材组	158	0.32±0.08	7（4.43）	64（40.51）	87（55.06）	24.21±7.61	23（14.56）	21（13.29）	114（72.15）
对照组	144	0.35±0.08	1（0.69）	36（25.00）	107（74.31）	27.28±7.86	11（7.64）	7（4.86）	126（87.50）
统计值		t=3.87	χ²=13.78			t=3.45	χ²=11.21
P值		<0.001	0.001			0.001	0.004

组别	例数	维生素A				维生素D
组别	例数	血清维生素A水平（mg/L， $x ¯$ ±s）	缺乏［例（%）］	边缘型缺乏［例（%）］	充足［例（%）］	（ng/ml，±s）血清25（OH）D水平	缺乏［例（%）］	不足［例（%）］	充足［例（%）］
矮身材组	158	0.32±0.08	7（4.43）	64（40.51）	87（55.06）	24.21±7.61	23（14.56）	21（13.29）	114（72.15）
对照组	144	0.35±0.08	1（0.69）	36（25.00）	107（74.31）	27.28±7.86	11（7.64）	7（4.86）	126（87.50）
统计值		t=3.87	χ²=13.78			t=3.45	χ²=11.21
P值		<0.001	0.001			0.001	0.004

项目	B	OR值	95%CI	P值
出生身长	0.041	1.041	0.859~1.263	0.680
出生体质量	-0.001	0.999	0.999~1.000	0.147
是否足月	1.096	2.993	0.947~9.456	0.062
父亲身高	-0.076	0.927	0.877~0.979	0.007
母亲身高	-0.023	0.977	0.927~1.030	0.387
运动少	0.445	1.560	0.653~3.725	0.317
食欲差	0.600	1.822	1.068~3.108	0.028
维生素A
边缘型缺乏	1.826	6.210	0.669~57.666	0.108
缺乏	0.558	1.747	0.980~3.115	0.059
维生素D
不足	0.788	2.198	0.877~5.506	0.093
缺乏	1.150	3.158	1.199~8.318	0.020

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