Correlation between carotid intima-media thickness and cardio-ankle vascular index in hypertension subjects

doi:10.3877/cma.j.issn.1674-0785.2021.07.001

Abstract

Abstract:

Objective

To investigate the correlation between carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI) in hypertension subjects.

Methods

A total of 324 subjects in Department of Vascular Medicine, Peking University Shougang Hospital were enrolled into our study, and they were divided into two groups based on blood pressure levels: control group (173 cases) and hypertension group (151 cases). Two-dimensional ultrasound and VS-1000 were used to measure CIMT and CAVI.

Results

The prevalence of coronary artery disease and stroke was significantly higher in the hypertension group than in the control group (P＜0.05). The levels of CIMT and CAVI were significantly higher in the hypertension group than in the control group [(0.62±0.23) mm vs (0.51±0.22) mm and 8.40±1.51 vs 7.46±1.10, respectively, P＜0.001 ]. There was a positive correlation between CIMT and CAVI in hypertension subjects (r=0.191, P＜0.05). Multivariate analysis showed that age and systolic blood pressure were independent risk factors for CIMT in hypertension subjects (β=0.253, P=0.004; β=0.283, P=0.001).

Conclusion

CIMT is significantly higher and positively correlated with CAVI in hypertension subjects, indicating the role of CIMT in predicting arteriosclerosis.

Key words: Carotid intima-media thickness, Cardio-ankle vascular index, Hypertension

Wei Huang, Hongyu Wang, Jinbo Liu, Huan Liu, Hongwei Zhao, Na Zhao. Correlation between carotid intima-media thickness and cardio-ankle vascular index in hypertension subjects[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(07): 481-484.

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URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2021.07.001

https://zhlcyszz.cma-cmc.com.cn/EN/Y2021/V15/I07/481

Figures/Tables 1

项目	对照组（173例）	高血压组（151例）	统计值	P值
年龄（岁， $x ¯$ ±s）	51.53±13.71	59.00±11.77	t=-6.707	＜0.001
男性［例（%）］	66（38.2）	61（40.4）	χ²=0.171	0.679
冠心病［例（%）］	2（1.2）	10（6.6）	χ²=6.678	0.009
糖尿病［例（%）］	8（4.6）	15（9.9）	χ²=3.510	0.063
卒中［例（%）］	0（0）	5（3.3）	χ²=6.005	0.005
动脉闭塞症［例（%）］	1（1.2）	3（2.0）	χ²=2.243	0.252
吸烟［例（%）］	68（39.3）	51（33.8）	χ²=1.062	0.303
体质量指数（kg/m²， $x ¯$ ±s）	22.17±3.05	23.22±3.73	t=-1.198	0.006
血糖（mmol/L， $x ¯$ ±s）	5.34±1.45	5.52±1.15	t=-1.198	0.232
尿酸（µmol/L， $x ¯$ ±s）	283.87±77.86	297.50±91.82	t=-1.407	0.160
总胆固醇（mmol/L， $x ¯$ ±s）	4.66±1.01	4.93±1.00	t=-2.247	0.025
高密度脂蛋白胆固醇（mmol/L， $x ¯$ ±s）	1.48±0.57	1.53±0.49	t=-0.787	0.432
低密度脂蛋白胆固醇（mmol/L， $x ¯$ ±s）	2.75±1.23	2.82±0.94	t=-0.530	0.597
三酰甘油（mmol/L， $x ¯$ ±s）	1.42±0.97	1.56±1.20	t=-1.101	0.272
糖化血红蛋白（%， $x ¯$ ±s）	5.61±0.53	5.77±0.53	t=-0.908	0.370
收缩压（mmHg， $x ¯$ ±s）	125.75±13.05	158.87±21.56	t=-16.959	＜0.001
舒张压（mmHg， $x ¯$ ±s）	80.70±8.72	96.26±12.24	t=-13.006	＜0.001
脉压（mmHg， $x ¯$ ±s）	45.05±9.55	62.60±16.02	t=-11.758	＜0.001
心率（次/min， $x ¯$ ±s）	68.29±10.87	72.40±14.41	t=-2.884	0.004
CIMT（mm， $x ¯$ ±s）	0.51±0.22	0.62±0.23	t=-4.144	＜0.001
CAVI	7.46±1.10	8.40±1.51	t=-6.360	＜0.001

项目	对照组（173例）	高血压组（151例）	统计值	P值
年龄（岁， $x ¯$ ±s）	51.53±13.71	59.00±11.77	t=-6.707	＜0.001
男性［例（%）］	66（38.2）	61（40.4）	χ²=0.171	0.679
冠心病［例（%）］	2（1.2）	10（6.6）	χ²=6.678	0.009
糖尿病［例（%）］	8（4.6）	15（9.9）	χ²=3.510	0.063
卒中［例（%）］	0（0）	5（3.3）	χ²=6.005	0.005
动脉闭塞症［例（%）］	1（1.2）	3（2.0）	χ²=2.243	0.252
吸烟［例（%）］	68（39.3）	51（33.8）	χ²=1.062	0.303
体质量指数（kg/m²， $x ¯$ ±s）	22.17±3.05	23.22±3.73	t=-1.198	0.006
血糖（mmol/L， $x ¯$ ±s）	5.34±1.45	5.52±1.15	t=-1.198	0.232
尿酸（µmol/L， $x ¯$ ±s）	283.87±77.86	297.50±91.82	t=-1.407	0.160
总胆固醇（mmol/L， $x ¯$ ±s）	4.66±1.01	4.93±1.00	t=-2.247	0.025
高密度脂蛋白胆固醇（mmol/L， $x ¯$ ±s）	1.48±0.57	1.53±0.49	t=-0.787	0.432
低密度脂蛋白胆固醇（mmol/L， $x ¯$ ±s）	2.75±1.23	2.82±0.94	t=-0.530	0.597
三酰甘油（mmol/L， $x ¯$ ±s）	1.42±0.97	1.56±1.20	t=-1.101	0.272
糖化血红蛋白（%， $x ¯$ ±s）	5.61±0.53	5.77±0.53	t=-0.908	0.370
收缩压（mmHg， $x ¯$ ±s）	125.75±13.05	158.87±21.56	t=-16.959	＜0.001
舒张压（mmHg， $x ¯$ ±s）	80.70±8.72	96.26±12.24	t=-13.006	＜0.001
脉压（mmHg， $x ¯$ ±s）	45.05±9.55	62.60±16.02	t=-11.758	＜0.001
心率（次/min， $x ¯$ ±s）	68.29±10.87	72.40±14.41	t=-2.884	0.004
CIMT（mm， $x ¯$ ±s）	0.51±0.22	0.62±0.23	t=-4.144	＜0.001
CAVI	7.46±1.10	8.40±1.51	t=-6.360	＜0.001

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