Application of patient-derived xenograft model in study of triple-negative breast cancer

doi:10.3877/cma.j.issn.1674-0785.2021.10.013

Abstract

Abstract:

Triple-negative breast cancer is one of the subtypes of breast cancer, which exhibits a lack of the expression of estrogen receptor and progesterone receptor and the amplification of human epidermal growth factor receptor 2. Compared with other subtypes, triple-negative breast cancer has a younger onset age, higher degree of malignancy, and worse prognosis, which has always been the focus of clinical and research. Patient-derived xenograft model is established by engrafting tumor tissue or primary cells into immunodeficient mice, which faithfully retains the biological features of the primary tumor. It has been widely used in the study of triple-negative breast cancer. This review describes the application of patient-derived xenograft model in the study of triple-negative breast cancer.

Key words: Triple-negative breast cancer, Patient-derived xenograft model, Animal model

Qiaoli Guo, Hui Hu. Application of patient-derived xenograft model in study of triple-negative breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(10): 790-793.

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References 30

1	International Agency for Research on Cancer. Global Cancer Observatory: Cancer Today [EB/OL]. [2021-01-11]. URL
2	Sasaki Y, Tsuda H. Clinicopathological characteristics of triple-negative breast cancers [J]. Breast Cancer, 2009, 16(4): 254-259.
3	Rhee J, Han SW, Oh DY, et al. The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer [J]. BMC Cancer, 2008, 8(1): 307.
4	Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence [J]. Clin Cancer Res, 2007, 13(15): 4429-4434.
5	Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer [J]. N Engl J Med, 2009, 353(16): 1673-1684.
6	Peto R, Davies C, Godwin J, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100000 women in 123 randomised trials [J]. The Lancet, 2012, 379(9814): 432-444.
7	Zhang X, Claerhout S, Prat A, et al. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models [J]. Cancer Research, 2013, 73(15): 4885-4897.
8	Manoir SD, Orsetti B, Rui BG, et al. Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse [J]. Mol Oncol, 2014, 8(2): 431-443.
9	Ledford H. US cancer institute to overhaul tumour cell lines [J]. Nature, 2016, 530(7591): 391-391.
10	Gómez-Miragaya J, Palafox M, Paré L, et al. Resistance to taxanes in triple-negative breast cancer associates with the dynamics of a CD49f+ tumor-initiating population [J]. Stem Cell Reports, 2017, 8(5): 1392-1407.
11	Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell [J]. J Cell Biochem, 2003, 88(4): 660.
12	Saatci O, Kaymak A, Raza U, et al. Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer [J]. Nat Commun, 2020, 11(1): 2416.
13	Marty B, Maire V, Gravier E, et al. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells [J]. Breast Cancer Res, 2008, 10(6): R101.
14	Zeng Q, Yang Z, Gao YJ, et al. Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study [J]. Eur J Cancer, 2010, 46(6): 1132-1143.
15	Zhang H, Cohen AL, Krishnakumar S, et al. Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition [J]. Breast Cancer Res, 2014, 16(2): R36.
16	Marangoni E, Laurent C, Coussy F, et al. Capecitabine efficacy is correlated with TYMP and RB expression in PDX established from triple-negative breast cancers [J]. Clin Cancer Res, 2018, 24(11): 2605-2615.
17	Cowan LA, Talwar S, Yang AS. Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors [J]. Epigenomics, 2010, 2(1): 71-86.
18	Jia Y, Bo Q, Moyer AM, et al. DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine [J]. J Clin Invest, 2018, 128(6): 2376-2388.
19	Dang C. MYC on the path to cancer [J]. Cell, 2012, 149(1): 22-35.
20	Dai H, Kusdra L, Huskey NE, et al. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition [J]. J Exp Med, 2012, 209(4): 679-696.
21	Dai H, Camarda R, Zhou AY, et al. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression [J]. Nat Med, 2016, 22(11): 1321-1329.
22	Liu Y, Zhou Y, Huang KH, et al. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor [J]. Cell Prolif, 2020, 53(8): e12858.
23	Contrino J, Hair G, Kreutzer DL, et al. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease [J]. Nat Med, 1996, 2(2): 209-215.
24	Duanmu J, Cheng J, Xu J, et al. Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor Ⅷ-targeted photodynamic therapy [J]. Br J Cancer, 2011, 104(9): 1401-1409.
25	Hu Z, Shen R, Campbell A, et al. Targeting tissue factor for immunotherapy of triple-negative breast cancer using a second-generation ICON [J]. Cancer Immunol Res, 2018, 6(6): 671-684.
26	Bourcy M, Suarez-Carmona M, Lambert J, et al. Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells [J]. Cancer Res, 2016, 76(14): 4270-4282.
27	Bousquet G, Feugeas JP, Ferreira I, et al. Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma [J]. Breast Cancer Res, 2014, 16(1): 401-403.
28	Moon HG, Oh K, Lee J, et al. Prognostic and functional importance of the engraftment-associated genes in the patient-derived xenograft models of triple-negative breast cancers [J]. Breast Cancer Res Treat, 2015, 154(1): 13-22.
29	Peterson JK, Houghton PJ. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development [J]. Eur J Cancer, 2004, 40(6): 837-844.
30	Izumchenko E, Paz K, Ciznadija D, et al. Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors [J]. Ann Oncol, 2017, 28(10): 2595-2605.

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