Correlation between inflammatory markers in maternal peripheral blood and pre-eclampsia

doi:10.3877/cma.j.issn.1674-0785.2021.11.012

Abstract

Abstract:

Objective

To explore the correlation of inflammatory indexes in peripheral blood, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio with pre-eclampsia in patients with pre-eclampsia and to assess their value in the prediction of pre-eclampsia.

Methods

From January 2018 to January 2019, 102 pregnant women who met the diagnostic criteria for pre-eclampsia at Jiangsu Subei People's Hospital were included in an observation group and 179 healthy pregnant women in the same period were included in a normal control group. The observation group was further divided into a mild pre-eclampsia subgroup (45 cases) and a severe pre-eclampsia group (57 cases). Fasting venous blood was collected from all subjects on the morning after admission to perform routine blood test. White blood cell count, neutrophil count, lymphocyte count, the number of monocytes, etc. were assessed, and neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were calculated. The correlation of these indexes with the severity of pre-eclampsia and their predictive value for pre-eclampsia were analyzed.

Results

The mean values of white blood cell count, neutrophil count, and neutrophil to lymphocyte ratio in the pre-eclampsia group were significantly higher than those in the normal control group (P＜0.001), and increased with the severity of the disease, however, platelet count and platelet to lymphocyte ratio in the pre-eclampsia group were significantly lower than those in the normal control group (P＜0.001). Receiver operating curve analysis showed that the area under the curve of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio was 0.773 and 0.735, respectively, suggesting that they had appreciated predictive value for pre-eclampsia.

Conclusion

Leukocyte count, neutrophil count, neutrophil to lymphocyte ratio, platelet count, and platelet to lymphocyte ratio are obviously different between pregnant women with pre-eclampsia and healthy pregnant women, and between pregnant women with mild pre-eclampsia and those with severe pre-eclampsia, suggesting that they are associated with pre-eclampsia and illness severity. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have some value in predicting preeclampsia.

Key words: Pre-eclampsia, Inflammatory markers, Neutrophil to lymphocyte ratio, Platelet to lymphocyte ratio

Danmo Zhu, Xueqiong Liu, Dan Lu. Correlation between inflammatory markers in maternal peripheral blood and pre-eclampsia[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(11): 865-870.

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Figures/Tables 4

组别	例数	年龄（岁， $x ¯$ ±s）	BMI（kg/m²， $x ¯$ ±s）	孕次（次， $x ¯$ ±s）	收缩压（mmHg， $x ¯$ ±s）	舒张压（mmHg， $x ¯$ ±s）	有子痫前期史［例（%）］	新生儿体质量（g， $x ¯$ ±s）	顺产［例（%）］	新生儿男性［例（%）］
轻度子痫前期组	45	28.23±3.93	23.93±3.89^a	1.68±0.91	151.35±13.25^a	98.28±8.75^a	4（8.89）^a	3257.37±746.28^a	22（48.89）^a	27（60.00）
重度子痫前期组	57	28.82±4.73	23.99±2.75^ab	2.42±1.95	172.87±14.95^ab	111.87±10.45^ab	3（5.26）^ab	2673.11±958.51^ab	5（8.77）^ab	22（38.60）
正常对照组	179	27.61±3.20	22.56±2.53	1.82±0.93	116.79±8.76	76.40±6.97	2（1.12）	3373.35±357.29	169（94.41）	86（48.04）
统计值		F=0.417	F=15.347	F=4.030	F=196.957	F=188.737	χ²=6.928	F=22.413	χ²=151.162	χ²=0.023
P值		0.578	＜0.001	0.133	＜0.001	＜0.001	0.031	0.031	＜0.001	0.988

组别	例数	年龄（岁， $x ¯$ ±s）	BMI（kg/m²， $x ¯$ ±s）	孕次（次， $x ¯$ ±s）	收缩压（mmHg， $x ¯$ ±s）	舒张压（mmHg， $x ¯$ ±s）	有子痫前期史［例（%）］	新生儿体质量（g， $x ¯$ ±s）	顺产［例（%）］	新生儿男性［例（%）］
轻度子痫前期组	45	28.23±3.93	23.93±3.89^a	1.68±0.91	151.35±13.25^a	98.28±8.75^a	4（8.89）^a	3257.37±746.28^a	22（48.89）^a	27（60.00）
重度子痫前期组	57	28.82±4.73	23.99±2.75^ab	2.42±1.95	172.87±14.95^ab	111.87±10.45^ab	3（5.26）^ab	2673.11±958.51^ab	5（8.77）^ab	22（38.60）
正常对照组	179	27.61±3.20	22.56±2.53	1.82±0.93	116.79±8.76	76.40±6.97	2（1.12）	3373.35±357.29	169（94.41）	86（48.04）
统计值		F=0.417	F=15.347	F=4.030	F=196.957	F=188.737	χ²=6.928	F=22.413	χ²=151.162	χ²=0.023
P值		0.578	＜0.001	0.133	＜0.001	＜0.001	0.031	0.031	＜0.001	0.988

组别	例数	WBC（×10⁹/L）	NE（×10⁹/L）	LY（×10⁹/L）	MON（×10⁹/L）	PLT（×10⁹/L）	PLR	NLR
轻度子痫前期组	45	10.62±1.48^a	8.02±1.30^a	1.32±0.40^a	0.57±0.26	171.72±28.67^a	137.53±35.13^a	6.42±1.56^a
重度子痫前期组	57	11.97±2.60^ab	9.01±2.59^ab	1.35±0.39^ab	0.54±0.26	118.71±23.10^ab	92.31±22.95^ab	7.06±2.42^ab
正常对照组	179	10.37±1.74	7.26±1.54	1.56±0.43	0.53±0.18	230.00±47.95	156.90±52.29	4.90±1.44
F值		16.875	29.321	23.853	0.633	142.165	74.488	58.373
P值		＜0.001	＜0.001	＜0.001	0.729	＜0.001	＜0.001	＜0.001

项目	AUC	标准误	渐进显著性	95%可信区间		特异度（%）	敏感度（%）	截断值
项目	AUC	标准误	渐进显著性	上限	下限	特异度（%）	敏感度（%）	截断值
PLR	0.735	0.031	0.000	0.675	0.795	54.9	78.8	0.337
NLR	0.773	0.033	0.000	0.708	0.838	72.5	84.4	0.569

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