Significance of serum levels of amyloid A, C-reactive protein, and alanine aminotransferase in early pregnancy patients with missed abortion

doi:10.3877/cma.j.issn.1674-0785.2021.12.015

Abstract

Abstract:

Objective

To assess the clinical significance of serum levels of amyloid A (SAA), C-reactive protein (CRP), and alanine aminotransferase (ALT) in early pregnancy patients with missed abortion.

Methods

A total of 104 patients with missed abortion in early pregnancy at Maternal and Child Health Hospital of Hubei from September 2019 to January 2020 were selected as an observation group, and 103 pregnant women who voluntarily requested termination of pregnancy were selected as a control group. The patients in the two groups were examined for the serum levels of SAA, CRP, and ALT. Logistic regression analysis was used to evaluate the risk factors for missed abortion during early pregnancy.

Results

Serum levels of SAA, CRP, and ALT in the observation group were significantly higher than those in the control group (P＜0.05). The area under the curve of serum SAA for the diagnosis of missed abortion in early pregnancy was 0.607 (P＜0.05), suggesting that serum SAA has diagnostic and predictive value for missed abortion. Multivariate Logistic regression analysis showed that age, pregnancy history, childbirth history, miscarriage, and dysmenorrhea were not independent risk factors for missed abortion (P＞0.05).

Conclusion

Serum levels of SAA, CRP, and ALT significantly increase in early pregnancy patients with missed abortion, and the high expression of these indicators might be involved in the occurrence and development of missed abortion.

Key words: Serum amyloid A, C-reactive protein, Missed abortion

Dan Yu, Bo Nie, Jianbo Xia. Significance of serum levels of amyloid A, C-reactive protein, and alanine aminotransferase in early pregnancy patients with missed abortion[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(12): 995-998.

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https://zhlcyszz.cma-cmc.com.cn/EN/Y2021/V15/I12/995

Figures/Tables 6

项目	观察组（104例）	对照组（103例）	t/χ²值	P值
孕妇年龄（岁， $x ¯$ ±s）	30.75±5.09	30.35±5.25	0.557	0.578
孕次［例（%）］			8.954	0.003
0~2次	61（58.70%）	39（37.90%）
3~5次	43（41.30%）	64（62.10%）
产次［例（%）］			77.891	＜0.001
0~1次	96（92.30%）	34（33.00%）
2~3次	8（7.70%）	69（67.00%）
流产［例（%）］			2.307	0.129
0~2次	95（91.30%）	87（84.50%）
3~5次	9（8.60%）	16（15.50%）
疤痕子宫［例（%）］			6.372	0.012
是	28（26.90%）	45（43.70%）
否	76（73.10%）	58（56.30%）
痛经［例（%）］			13.533	＜0.001
是	17（16.30%）	1（0.97%）
否	87（83.70%）	102（99.03%）
饮酒［例（%）］			0.245	0.318
是	3（2.90%）	1（0.97%）
否	101（97.10%）	102（99.03%）
吸烟史［例（%）］			0.329	0.567
是	2（1.90%）	1（0.97%）
否	102（98.10%）	102（99.03%）

项目	观察组（104例）	对照组（103例）	t/χ²值	P值
孕妇年龄（岁， $x ¯$ ±s）	30.75±5.09	30.35±5.25	0.557	0.578
孕次［例（%）］			8.954	0.003
0~2次	61（58.70%）	39（37.90%）
3~5次	43（41.30%）	64（62.10%）
产次［例（%）］			77.891	＜0.001
0~1次	96（92.30%）	34（33.00%）
2~3次	8（7.70%）	69（67.00%）
流产［例（%）］			2.307	0.129
0~2次	95（91.30%）	87（84.50%）
3~5次	9（8.60%）	16（15.50%）
疤痕子宫［例（%）］			6.372	0.012
是	28（26.90%）	45（43.70%）
否	76（73.10%）	58（56.30%）
痛经［例（%）］			13.533	＜0.001
是	17（16.30%）	1（0.97%）
否	87（83.70%）	102（99.03%）
饮酒［例（%）］			0.245	0.318
是	3（2.90%）	1（0.97%）
否	101（97.10%）	102（99.03%）
吸烟史［例（%）］			0.329	0.567
是	2（1.90%）	1（0.97%）
否	102（98.10%）	102（99.03%）

组别	例数	SAA（mg/L）	ALT（U/L）	CRP（mg/L）
观察组	104	7.69±19.6	17.09±13.1	4.12±7.63
对照组	103	3.03±2.78	13.75±8.4	2.40±2.77
t值		-2.410	-2.170	-2.150
P值		0.018	0.031	0.033

组别	例数	SAA（mg/L）
低孕次（0~2次）	61	3.64±3.48
高孕次（3~5次）	43	13.43±29.41
t值		-2.174
P值		0.035

指标	最佳临界值	敏感度（%）	特异度（%）	曲线下面积	95%CI
SAA	2.99 mg/L	51.0	68.6	0.607	0.529~0.684
CRP	2.51 mg/L	46.0	68.9	0.573	0.500~0.639
ALT	12.1 U/L	54.9	59.8	0.556	0.485~0.625

因素	β值	SE	Wald χ²值	P值	OR值	95%CI
年龄	0.358	0.385	0.867	0.352	1.431	0.673~3.043
妊娠史	-0.391	0.586	0.446	0.504	0.676	0.214~2.133
痛经史	-0.090	0.357	0.063	0.802	0.914	0.455~1.839
流产史	0.401	0.457	0.772	0.380	1.494	0.610~3.655
分娩史	-0.573	0.372	2.370	0.124	0.564	0.272~1.169

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