Relationship between serum n-pentamerin 3 level and blood lipids, cognitive function, and prognosis in patients with acute cerebral infarction

doi:10.3877/cma.j.issn.1674-0785.2022.05.009

Abstract

Abstract:

Objective

To explore the relationship between serum n-pentamerin 3 (PTX3) level and blood lipids, cognitive function, and prognosis in patients with acute cerebral infarction (ACI).

Methods

The clinical data of 94 patients with ACI (observation group) treated at Hainan Western Central Hospital from April 2018 to October 2020 were analyzed retrospectively. Ninety-two healthy people receiving health check in the same period were selected as controls. Blood lipids and serum PTX3 levels of the two groups were detected, and the scores of modified Hasegawa Dementia Scale (HDS-R) and modified Rankin Scale (mRS) were evaluated and compared between the two groups. The observation group was divided into two groups according to the results of carotid ultrasound examination, namely, unstable group (n=35, with unstable plaque) and stable group (n=59, with stable plaque). The mRS score, HDS-R score, blood lipids, and PTX3 level in the two groups were compared. Pearson correlation analysis and multivariate stepwise regression analysis were performed to explore the correlation between PTX3 level and HDS-R score, MRS score, and blood lipid levels.

Results

PTX3, total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in the observation group were all higher than those in the control group, and high density lipoprotein cholesterol (HDL-C), HDS-R score, and mRS score in the observation group were all lower than those in the control group (P＜0.05). PTX3, TC, TG, LDL-C, and mRS score in the unstable group were all higher than those in the stable group, and HDL-C and HDS-R score were both lower than those in the stable group (P＜0.05). Pearson correlation analysis showed that the level of PTX3 was positively correlated with TC, TG, LDL-C, and mRS (r=0.808, 0.506, 0.833, and 0.769, respectively, P＜0.001), and negatively correlated with the score of HDS-R (r=-0.419, P＜0.001). Multiple stepwise regression analysis showed that TC, LDL-C, and mRS had a significant positive impact on PTX3 (t=2.673, 3.579, and 2.708, respectively, P＜0.05).

Conclusion

The expression of PTX3 in patients with ACI is significantly increased, and it is negatively correlated with HDS-R score, and has a positive effect on TC, TG, and prognosis.

Key words: Acute cerebral infarction, Pentraxin 3, Blood lipids, Cognitive function, Prognosis, Relationship

Ying Lin, Jianhong Li, Hongquan Lu, Junling Chen. Relationship between serum n-pentamerin 3 level and blood lipids, cognitive function, and prognosis in patients with acute cerebral infarction[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(05): 420-424.

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References 15

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组别	例数	PTX3（μg/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HDS（分）	mRS（分）
观察组	94	2.86±0.56	4.59±0.49	1.49±0.23	1.37±0.19	2.39±0.24	18.75±2.68	1.89±0.75
对照组	92	1.12±0.04	4.02±0.11	1.01±0.11	1.86±0.22	2.01±0.11	31.42±0.12	3.46±0.14
t值		29.727	10.892	18.094	16.268	13.831	45.299	19.744
P值		＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001

组别	例数	PTX3（μg/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HDS（分）	mRS（分）
观察组	94	2.86±0.56	4.59±0.49	1.49±0.23	1.37±0.19	2.39±0.24	18.75±2.68	1.89±0.75
对照组	92	1.12±0.04	4.02±0.11	1.01±0.11	1.86±0.22	2.01±0.11	31.42±0.12	3.46±0.14
t值		29.727	10.892	18.094	16.268	13.831	45.299	19.744
P值		＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001

组别	例数	PTX3（μg/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HDS评分（分）	mRS评分（分）
稳定组	59	2.13±0.49	4.24±0.19	1.29±0.13	1.49±0.35	2.15±0.13	22.49±3.62	1.06±0.10
不稳定组	35	3.54±0.32	4.78±0.23	1.65±0.54	1.21±0.11	2.69±0.28	15.32±2.45	2.84±0.83
t值		23.182	17.473	6.281	7.327	16.927	15.786	20.424
P值		＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001

组别	例数	PTX3（μg/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HDS评分（分）	mRS评分（分）
稳定组	59	2.13±0.49	4.24±0.19	1.29±0.13	1.49±0.35	2.15±0.13	22.49±3.62	1.06±0.10
不稳定组	35	3.54±0.32	4.78±0.23	1.65±0.54	1.21±0.11	2.69±0.28	15.32±2.45	2.84±0.83
t值		23.182	17.473	6.281	7.327	16.927	15.786	20.424
P值		＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001

模型	非标准化系数		标准系数	t值	P值	VIF	R²	调整R²
模型	回归系数	标准错误	标准系数	t值	P值	VIF	R²	调整R²
常数	-3.082	0.821	-	-3.753	＜0.001	-	0.752	0.735
TC	0.722	0.270	0.296	2.673	0.009	4.322
TG	0.083	0.141	0.039	0.588	0.558	1.567
HDL-C	0.235	0.180	0.091	1.302	0.196	1.729
LDL-C	1.063	0.297	0.431	3.579	＜0.001	5.098
HDS评分	-0.004	0.014	-0.021	-0.256	0.799	2.399
mRS评分	0.153	0.056	-0.228	2.708	0.008	2.488

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