Feasibility of short-term filgrastim in supporting dose-dense neoadjuvant chemotherapy for primary breast cancer

doi:10.3877/cma.j.issn.1674-0785.2022.06.002

Abstract

Abstract:

Objective

To retrospectively assess the efficacy and safety of short-term filgrastim in supporting dose-dense neoadjuvant chemotherapy (ddEC) for primary breast cancer based on a single database, in order to examine the feasibility of this method.

Methods

Data of patients who received dose-dense neoadjuvant chemotherapy with support of short-term filgrastim at Peking University Cancer Hospital Breast Cancer Prevention and Treatment Center from July 2015 to June 2018 were retrospectively collected. All of these patients were planned to receive four cycles of ddEC (Epirubicin 100 mg/m² and cyclophosphamide 600 mg/m²) with the usage of rhG-CSF as follows: Filgrastim 200-300 μg/d on days 4, 6, 8, and 10. The relative dose intensity (RDI) was calculated based on chemotherapy delay and the number of dosage reductions, as well as febrile neutropenia (FN).

Results

A total of 301 patients were enrolled in this study. Chemotherapy induced neutropenia related chemotherapy delay occurred in 15 patients (5.0%; 95% confidence interval [CI]: 2.5%~7.5%), 289 patients achieved an RDI≥85% (96%; 95CI: 93.8%~98.2%), and FN occurred in 14 patients (4.7%; 95%CI: 2.3%~7.1%).

Conclusion

According to this study, short-term filgrastim is feasible in supporting four cycles of neoadjuvant chemotherapy for primary breast cancer.

Jingyi Zhao, Yingjian He, Jinfeng Li, Zhaoqing Fan, Tianfeng Wang, Yang Yang, Xinguang Wang, Xue Chen, Yangtao Ou. Feasibility of short-term filgrastim in supporting dose-dense neoadjuvant chemotherapy for primary breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(06): 469-473.

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References 36

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终止化疗原因	人数［例（%）］ n=9	比例（%） n=301
临床评价肿瘤进展	3（33.3）	1.0
可疑与表阿霉素相关的心脏毒性	3（33.3）	1.0
CIN	1（11.1）	0.3
三系减低	1（11.1）	0.3
严重的化疗相关消化道毒性	1（11.1）	0.3

终止化疗原因	人数［例（%）］ n=9	比例（%） n=301
临床评价肿瘤进展	3（33.3）	1.0
可疑与表阿霉素相关的心脏毒性	3（33.3）	1.0
CIN	1（11.1）	0.3
三系减低	1（11.1）	0.3
严重的化疗相关消化道毒性	1（11.1）	0.3

延迟化疗原因	人数［例（%）］ n=32	比例（%） n=301
CIN	15（46.9）	5.0
转氨酶异常	10（31.3）	3.3
上呼吸道感染（ANC正常）	2（6.3）	0.7
4度贫血	1（3.1）	0.3
严重的化疗相关消化道毒性	1（3.1）	0.3
其他^*	3（9.4）	1.0

延迟化疗原因	人数［例（%）］ n=32	比例（%） n=301
CIN	15（46.9）	5.0
转氨酶异常	10（31.3）	3.3
上呼吸道感染（ANC正常）	2（6.3）	0.7
4度贫血	1（3.1）	0.3
严重的化疗相关消化道毒性	1（3.1）	0.3
其他^*	3（9.4）	1.0

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