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Chinese Journal of Clinicians(Electronic Edition) ›› 2022, Vol. 16 ›› Issue (10): 982-988. doi: 10.3877/cma.j.issn.1674-0785.2022.10.011

• Clinical Research • Previous Articles     Next Articles

Risk factors for neutropenia in patients with non-Hodgkin B-Cell lymphoma after chemotherapy and their relationship with outcomes

Jingxian Li1, Yanying Wang1, Jiao Li1, Lihong Li1,()   

  1. 1. Department of Hematology and Oncology, Tsinghua Chang Gung Hospital, Beijing 102218, China
  • Received:2022-07-26 Online:2022-10-15 Published:2023-03-18
  • Contact: Lihong Li

Abstract:

Objective

To identify potential risk factors for the occurrence of neutropenia and infection in patients diagnosed with B-cell lymphoma, and explore their relationship with outcomes of chemotherapy.

Methods

Patients with non-Hodgkin B-cell lymphoma who were treated at the Department of Oncology and Hematology, Tsinghua Chang Gung Hospital, Beijing from June 2016 to June 2021 were included. The chemotherapy regimens were generally based on the standard R-CHOP regimen. The factors analyzed in the study included gender, age at first diagnosis, body mass index, tumor stage & group, the presence of hepatitis B or not, chemotherapy courses, whether neutropenia occurred during the present chemotherapy course and its cumulative duration, whether there was severe infection, and baseline laboratory test indicators. The analyses were performed by mixed effects and binary logistic regression.

Results

Among the 253 times of chemotherapy in 39 patients, 58.97% had neutropenia. Hepatitis B and stage IV were the risk factors for neutropenia and its prolongation. Hepatitis B was also a risk factor for serious infection. Neutropenia and its prolonged duration were risk factors for poor treatment outcome.

Conclusion

Hepatitis B and stage IV may be risk factors for agranulocytosis during chemotherapy in patients with B-cell lymphoma, and may lead to poor chemotherapy outcomes.

Key words: B-cell lymphoma, Neutropenia, Infection, Chemotherapy effect

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