Effect of Ankun Zhongzi pills combined with Femoston on luteinizing hormone and dehydroepiandrosterone sulfate in patients with decreased ovarian reserve function

doi:10.3877/cma.j.issn.1674-0785.2023.02.008

Abstract

Abstract:

Objective

To investigate the effects of Ankun Zhongzi pills combined with Femoston on luteinizing hormone and dehydroepiandrosterone sulfate (DHEA-S) in patients with decreased ovarian reserve.

Methods

A total of 100 patients with decreased ovarian reserve function were enrolled at Qionghai City Hospital of Traditional Chinese Medicine of Gynecology from May 2019 to May 2021. They were randomly divided into either a control group or a study group by rolling dice, with 50 patients in each group. The two groups were first given oral vitamin E and conventional treatment (eating more soy food). Patients in the control group received oral treatment of Femoston after routine treatment, and patients in the study group received oral treatment of Ankun Zhongzi pills+Femoston after routine treatment. After treatment, the levels of luteinizing hormone (LH), DHEA-S, follicle-stimulating hormone (FSH), estradiol (E2), and anti-Mullerian hormone (AMH) were determined, and electrochemiluminescence detection of sex hormone binding globulin (SHBG) was performed. The rate of adverse reactions and the effective rate were statistically analyzed in the two groups.

Results

After treatment, the levels of DHEA-S, LH, and FSH in both groups were significantly lower than those before treatment, while the level of E2 was significantly higher than that before treatment (P＜0.05). The levels of DHEA-S, LH, and FSH in the study group were significantly lower than those in the control group, while the level of E2 was significantly higher than that in the control group (P＜0.05). After treatment, SHBG and AMH in both groups were significantly higher than those before treatment (P＜0.05); SHBG and AMH in the study group were significantly higher than those in the control group (P＜0.05). The total effective rate was significantly higher in the study group than in the control group (P＜0.05).

Conclusion

Ankun Zhongzhi pills combined with Femoston can effectively improve the levels of LH, DHEA-S, and estrogen in patients with decreased ovarian reserve, and the ovarian reserve can recover better.

Key words: Ankun Zhongzi pills, Femoston, Decreased ovarian reserve, Luteinizing hormone, Dehydroepiandrosterone sulfate

Sui Liu, Xiangxin Niu, Meiyan Li, Xiaomei Luo. Effect of Ankun Zhongzi pills combined with Femoston on luteinizing hormone and dehydroepiandrosterone sulfate in patients with decreased ovarian reserve function[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(02): 154-158.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2023.02.008

https://zhlcyszz.cma-cmc.com.cn/EN/Y2023/V17/I02/154

Figures/Tables 7

一般资料	对照组（n=50）	研究组（n=50）	t/χ²值	P值
年龄（岁， $x ¯$ ±s）	26.60±4.75	26.13±6.17	0.427	0.670
平均病程（月， $x ¯$ ±s）	18.24±14.06	19.95±14.25	0.604	0.547
婚姻状况［例（%）］			0.679	0.410
已婚	33（66.00）	29（58.00）
未婚	17（34.00）	21（42.00）
学历［例（%）］			0.817	0.665
高中及以下	7（14.00）	5（10.00）
大专	25（50.00）	23（46.00）
本科及以上	18（36.00）	22（44.00）

一般资料	对照组（n=50）	研究组（n=50）	t/χ²值	P值
年龄（岁， $x ¯$ ±s）	26.60±4.75	26.13±6.17	0.427	0.670
平均病程（月， $x ¯$ ±s）	18.24±14.06	19.95±14.25	0.604	0.547
婚姻状况［例（%）］			0.679	0.410
已婚	33（66.00）	29（58.00）
未婚	17（34.00）	21（42.00）
学历［例（%）］			0.817	0.665
高中及以下	7（14.00）	5（10.00）
大专	25（50.00）	23（46.00）
本科及以上	18（36.00）	22（44.00）

组别	例数	LH（U/L）		DHEA-S（μg/dl）
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	50	15.21±3.26	7.87±1.59	9.89±3.96	8.24±3.16
研究组	50	14.98±3.25	4.54±1.20	10.01±4.12	6.26±2.21
t值		0.353	11.820	0.149	3.631
P值		0.725	0.001	0.882	0.001

组别	FSH（U/L）		E2（pmol/L）
组别	治疗前	治疗后	治疗前	治疗后
对照组（n=50）	69.85±3.95	30.87±4.54	45.59±5.95	86.98±10.45
研究组（n=50）	69.26±3.39	21.22±4.00	46.01±5.26	118.01±8.01
t值	0.802	11.280	0.374	16.660
P值	0.425	＜0.001	0.710	＜0.001

组别	例数	SHBG（nmol/L）		AMH（ng/ml）
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	50	37.44±15.53	52.44±15.87	1.52±0.40	5.14±1.65
研究组	50	36.74±15.62	74.98±16.24	1.58±0.35	7.54±2.11
t值		0.225	7.019	0.798	6.336
P值		0.823	0.001	0.427	0.001

组别	例数	头痛	皮疹	乳房胀痛	总不良反应发生率
对照组	50	2（4.00）	2（4.00）	4（8.00）	8（16.00）
研究组	50	1（2.00）	2（4.00）	3（6.00）	6（12.00）
χ²值					0.332
P值					0.564

组别	例数	显效	有效	无效	总有效率
对照组	50	12（24.00）	27（54.00）	11（22.00）	39（78.00）
研究组	50	38（76.00）	11（22.00）	1（2.00）	49（98.00）
χ²值					9.470
P值					0.002

组别	例数	SHBG（nmol/L）	AMH（ng/ml）	妊娠率
对照组	50	65.98±17.24	6.87±1.87	40（22.00）
研究组	50	75.85±16.98	9.47±2.54	48（2.00）
t/χ²值		2.884	5.829	6.061
P值		0.004	0.001	0.014

References 21

1	Huang B, Qian C, Ding C, et al. Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1 [J]. Stem Cell Res Ther, 2019, 10(1):362.
2	王酩, 王树庆, 姜国辉. 归肾丸联合芬吗通对卵巢储备功能低下性不孕患者促排卵效果及性激素水平的影响研究 [J]. 中国煤炭工业医学杂志, 2018, 21(3): 258-261.
3	王红霞, 谢钻玲, 刘淑平, 等. 血清DHEA-S和维生素E与卵巢储备功能下降的相关性研究 [J]. 现代妇产科进展, 2020, 29(3): 218-220.
4	杨润雨, 张杨, 冯晓玲. 卵巢储备功能下降所致不孕症中西医机制及治疗进展探析 [J]. 辽宁中医药大学学报, 2019, 21(9): 189-192.
5	韩明, 周蓉, 尹东辉, 等. 卵巢储备功能下降子宫内膜癌孕激素治疗后中西医结合助孕成功一例 [J]. 中国妇产科临床杂志, 2018, 19(6): 552-553.
6	班姻子, 周华. 卵巢储备功能下降中西医治疗进展 [J]. 辽宁中医药大学学报, 2019, 21(6): 90-93.
7	Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: acommittee opinion [J]. Fertil Steril, 2015, 103: e9-e17.
8	刘昭阳. 从《中医妇科学》新版教材看中医妇科教育发展 [J]. 中医杂志, 2003, 44(10): 788-789.
9	李晶, 王韵, 吴克瑾, 等. 补肾调肝汤结合雌激素治疗卵巢储备功能低下性不孕不育症患者临床疗效评估 [J]. 辽宁中医药大学学报, 2020, 22(1): 113-116.
10	Sullivan SD, Sarrel PM, Nelson LM. Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause [J]. Fertil Steril, 2016, 106(7): 1588-1599.
11	兰丽琴, 胡盛书, 马晓炜, 等. 卵巢储备功能下降的中医辨证及其临床特点 [J]. 广西医学, 2020, 42(1): 86-89.
12	陈玉庆, 刘迎萍, 黄腾辉, 等. 安坤种子丸对卵巢储备功能下降(肾虚证)患者FSH, LH, FSH/LH的影响 [J]. 西部中医药, 2017, 30(3): 109-111.
13	竺卫达, 齐聪, 万怡婷. 齐氏养卵方治疗IVF-ET中卵巢储备功能下降患者的临床观察 [J]. 上海中医药杂志, 2019, 53(9): 64-67.
14	刘迎萍, 陈玉庆, 屈红. 安坤种子丸对卵巢储备功能下降致不孕症AFC和OV的影响 [J]. 西部中医药, 2017, 30(5): 111-113.
15	杨华娣, 邵一峰, 单双双, 等. 金匮温经汤联合芬吗通治疗化疗源性卵巢早衰的临床疗效 [J]. 中成药, 2019, 41(5): 1197-1199.
16	刘梅云, 李烨, 郝婉姣. 芬吗通治疗卵巢储备功能下降及卵巢早衰的临床研究 [J]. 生殖医学杂志, 2015, 24(3): 225-229.
17	张宁, 陈姗姗, 杨文秀. 芬吗通联合用药改善多囊卵巢综合征患者冻融胚胎移植周期子宫内膜血流及妊娠结局的研究 [J]. 生殖医学杂志, 2017, 26(7): 699-704.
18	陈玉庆, 潘文, 刘迎萍, 等. 安坤种子丸对卵巢储备功能下降(肾虚证)患者AMH及INHB的影响 [J]. 西部中医药, 2018, 31(2): 90-92.
19	岳瑶函, 赵嘉晶. 中西医结合治疗卵巢储备功能下降综合征致月经稀发的疗效分析及性激素水平相关性研究 [J]. 山西医药杂志, 2016, 45(12): 1382-1384.
20	李晓林, 汤华, 李丽. 归肾丸加减联合芬吗通治疗卵巢储备功能低下性不孕患者临床效果及对性激素水平影响 [J]. 临床误诊误治, 2019, 32(5): 54-58.
21	陆迪, 李秋冶, 丛培玮. 中西医治疗卵巢储备功能下降研究述评 [J]. 河南中医, 2020, 39(9): 1445-1449.

[1]	Yingchun Gao, Changqing Pan, Yao Zhang. Therapeutic effect of hydrotubation combined with bromocriptine in treatment of infertility patients caused by hyperprolactinemia complicated with tubal obstruction and its effect on serum luteinizing hormone and anti-acrosin antibody [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(04): 444-450.
[2]	Ge-ping YIN, Ai-fang WU, Xiu-xia GUO, Tong-yu ZHU. Influence of Endometrial Ablation Procedures Using Two Different Ways of Radiofrequency Thermocoagulation for Treatment of Dysfunctional Uterine Bleeding on Female Reproductive Endocrine [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(03): 300-304.
[3]	Shuyu Xie, Qi Li, Caiyun Si, Yuehong Tao. Comparison of clinical characteristics between peripheral and central precocious puberty girls with basal luteinizing hormone less than 0.1 IU/L [J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(02): 111-115.
[4]	Yue Hou, Fupeng Liu, Yanhong Zhang, Mei Zhang, Bo Ban, Qianqian Zhao, Hongli Zhang, Yanying Li. The predictive power of basal luteinizing hormone level for central gonadal activation states in girls [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 109-114.
[5]	Fuxia Li, Huarui Fan, Guiyu Hu, Yan Sheng. The effect of human chorionic gonadotrophin injection day serum luteinizing hormone level on pregnancy outcome [J]. Chinese Journal of Diagnostics(Electronic Edition), 2019, 07(02): 124-128.
[6]	Jing Wang, Yongkang Wang, Ping Lu. Effects of stress on gastric mucosal inflammation and premature ovarian failure in female mice [J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(02): 69-76.
[7]	Amina·Shawuti, Aziguli·Alimujiang, Maimaiti·Yisireyili, Jing Wang, Ababokeli·Wusiman, Meihua Chen, Ping Lu, Kelimu·Abudureyimu. Analysis Clinical Effect of Femoston with Esomeprazole Treatment on GERD in Perimenopausal Women [J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2021, 08(03): 123-128.

Please choose a citation manager

Content to export