Correlation between neutrophil/high-density lipoprotein ratio and lower extremity arterial disease in middle-aged and elderly people

doi:10.3877/cma.j.issn.1674-0785.2023.04.007

Abstract

Abstract:

Objective

To investigate the correlation between the neutrophil/high-density lipoprotein ratio (NHR) and lower extremity atherosclerotic disease (LEAD) in middle-aged and elderly people.

Methods

A total of 644 middle-aged and elderly inpatients treated at the Department of Vascular Medicine, Peking University Shougang Hospital from January 2016 to October 2017 were selected. According to brachial and ankle index, the patients were divided into either a non-LEAD group (n=578) or an LEAD group (n=66). Data collected at baseline included participants' demographic data, lifestyle, disease history, routine blood examination, and biochemistry examination. Pearson correlation analysis was used to analyze the correlation between NHR and LEAD. ROC curves were plotted to determine the predictive performance of NHR for LEAD. Multivariate Logistic regression was used to analyze the influencing factors of LEAD. One-way analysis of variance was used to compare the vascular function of different NHR groups.

Results

There was no significant difference in age, sex, smoking history, drinking history, hypertension, diabetes, hyperuricemia, medication history, MON, TC, TG, AST, ALT, TBIL, DBIL, Cr, hsCRP, or HCY between the non-LEAD group and the LEAD group (P＞0.05). WBC and NEU in the LEAD group were significantly higher than those in the non-LEAD group, while LYM, LDL, and HDL in the non-LEAD group were significantly higher than those in the LEAD group (P＜0.05 or P＜0.01). Pearson correlation analysis showed that there was a negative correlation between NHR and ABI in the middle-aged and elderly population (P＜0.01). Multivariate Logistic regression showed that NHR was an independent risk factor for LEAD (P＜0.05). One-way ANOVA showed that there were significant differences in ABI, CAVI, and CF-PWV among the groups with different levels of NHR (P＜0.05). ABI in the high NHR group was smaller than that in the low NHR group, while CAVI and CF-PWV were higher in the high NHR group.

Conclusion

The increase of NHR in middle-aged and elderly people is associated with LEAD, which has important value in predicting the incidence of LEAD in this population.

Key words: Neutrophil/high density lipoprotein ratio, Lower extremity arterial disease, Correlation analysis

Jie Chen, Yi Bai, Jinbo Liu, Huan Liu, Na Zhao, Hongwei Zhao, Hongyu Wang. Correlation between neutrophil/high-density lipoprotein ratio and lower extremity arterial disease in middle-aged and elderly people[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 402-408.

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Figures/Tables 6

指标	LEAD组（66例）	非LEAD组（578例）	统计值	P值
年龄（岁， $x ¯$ ±s）	61.76±11.47	61.40±10.96	-0.247	0.805
男性［例（%）］	29（43.94）	241（41.70）	0.122	0.793
吸烟史［例（%）］	14（21.21）	147（25.43）	1.434	0.488
饮酒史［例（%）］	23（34.85）	171（29.74）	0.817	0.664
高血压［例（%）］	51（77.27）	402（69.55）	1.693	0.255
糖尿病［例（%）］	28（42.42）	212（36.68）	0.837	0.420
高尿酸血症［例（%）］	4（6.06）	33（5.71）	0.013	0.784
他汀类药物［例（%）］	30（45.45）	233（40.30）	0.032	0.421
ACEI/ARB［例（%）］	14（21.21）	132（22.84）	0.305	0.760
β受体阻滞剂［例（%）］	10（15.20）	99（17.10）	0.165	0.420
钙拮抗剂［例（%）］	12（18.20）	125（21.60）	0.420	0.319
利尿剂［例（%）］	22（33.30）	180（31.10）	0.132	0.407
WBC（10⁹/L）	6.40（5.18~8.15）	6.00（4.90~7.10）	2.163	0.031
NEU（10⁹/L）	4.54±1.97	3.83±1.47	-2.816	0.006
LYM（10⁹/L）	1.50（1.10~1.90）	1.60（1.30~2.00）	-2.139	0.032
MON（10⁹/L）	0.50（0.40~0.60）	0.40（0.30~0.50）	1.721	0.085
TC（mmol/L， $x ¯$ ±s）	4.49±1.11	4.82±2.96	0.890	0.374
TG（mmol/L）	1.39（0.90~1.98）	1.41（1.04~1.96）	-0.646	0.518
HDL（mmol/L）	1.09（0.90~1.33）	1.17（0.98~1.40）	-2.450	0.014
LDL（mmol/L， $x ¯$ ±s）	2.54±0.80	2.84±0.92	2.536	0.011
ALT（U/L， $x ¯$ ±s）	17.44±7.63	19.67±14.44	1.233	0.218
AST（U/L， $x ¯$ ±s）	22.70±5.62	24.42±12.51	1.104	0.270
TBil（mmol/L， $x ¯$ ±s）	14.19±6.51	14.05±6.75	-0.165	0.869
DBil（mmol/L， $x ¯$ ±s）	3.95±2.53	4.18±2.46	0.713	0.476
Cr（μmol/L， $x ¯$ ±s）	70.28±25.60	72.81±25.14	0.770	0.441
hsCRP（mg/L）	1.65（0.78~2.90）	1.50（0.75~3.00）	-0.050	0.960
Hcy（μmol/L， $x ¯$ ±s）	16.10±7.85	16.36±8.26	0.233	0.816
NHR（ $x ¯$ ±s）	4.40±2.23	3.42±1.73	-3.446	0.001

指标	LEAD组（66例）	非LEAD组（578例）	统计值	P值
年龄（岁， $x ¯$ ±s）	61.76±11.47	61.40±10.96	-0.247	0.805
男性［例（%）］	29（43.94）	241（41.70）	0.122	0.793
吸烟史［例（%）］	14（21.21）	147（25.43）	1.434	0.488
饮酒史［例（%）］	23（34.85）	171（29.74）	0.817	0.664
高血压［例（%）］	51（77.27）	402（69.55）	1.693	0.255
糖尿病［例（%）］	28（42.42）	212（36.68）	0.837	0.420
高尿酸血症［例（%）］	4（6.06）	33（5.71）	0.013	0.784
他汀类药物［例（%）］	30（45.45）	233（40.30）	0.032	0.421
ACEI/ARB［例（%）］	14（21.21）	132（22.84）	0.305	0.760
β受体阻滞剂［例（%）］	10（15.20）	99（17.10）	0.165	0.420
钙拮抗剂［例（%）］	12（18.20）	125（21.60）	0.420	0.319
利尿剂［例（%）］	22（33.30）	180（31.10）	0.132	0.407
WBC（10⁹/L）	6.40（5.18~8.15）	6.00（4.90~7.10）	2.163	0.031
NEU（10⁹/L）	4.54±1.97	3.83±1.47	-2.816	0.006
LYM（10⁹/L）	1.50（1.10~1.90）	1.60（1.30~2.00）	-2.139	0.032
MON（10⁹/L）	0.50（0.40~0.60）	0.40（0.30~0.50）	1.721	0.085
TC（mmol/L， $x ¯$ ±s）	4.49±1.11	4.82±2.96	0.890	0.374
TG（mmol/L）	1.39（0.90~1.98）	1.41（1.04~1.96）	-0.646	0.518
HDL（mmol/L）	1.09（0.90~1.33）	1.17（0.98~1.40）	-2.450	0.014
LDL（mmol/L， $x ¯$ ±s）	2.54±0.80	2.84±0.92	2.536	0.011
ALT（U/L， $x ¯$ ±s）	17.44±7.63	19.67±14.44	1.233	0.218
AST（U/L， $x ¯$ ±s）	22.70±5.62	24.42±12.51	1.104	0.270
TBil（mmol/L， $x ¯$ ±s）	14.19±6.51	14.05±6.75	-0.165	0.869
DBil（mmol/L， $x ¯$ ±s）	3.95±2.53	4.18±2.46	0.713	0.476
Cr（μmol/L， $x ¯$ ±s）	70.28±25.60	72.81±25.14	0.770	0.441
hsCRP（mg/L）	1.65（0.78~2.90）	1.50（0.75~3.00）	-0.050	0.960
Hcy（μmol/L， $x ¯$ ±s）	16.10±7.85	16.36±8.26	0.233	0.816
NHR（ $x ¯$ ±s）	4.40±2.23	3.42±1.73	-3.446	0.001

指标

LEAD组

（66例）

非LEAD组

（578例）

自变量	回归系数β	P值	OR值	OR值95%CI
NHR	0.294	P＜0.05	1.341	1.240~1.442

4.39＜NHR

（n=161）

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