Hydrogen for treatment of myocardial ischemia-reperfusion injury: mechanism and prospect

doi:10.3877/cma.j.issn.1674-0785.2023.06.020

Abstract

Abstract:

Myocardial ischemia-reperfusion injury (MIRI) is one of the key causes of myocardial injury, secondary to cardiovascular diseases, which is mostly present in coronary heart disease and during the perioperative period of cardiac surgery. MIRI elicits oxidative stress, inflammatory activity, and cell apoptosis, with a high incidence and mortality rate. The current treatments for MIRI include medicines and physical therapy, but with unsatisfactory effects. As a small molecule non-toxic reducing gas, hydrogen has a clear protective effect against cell ischemia-reperfusion, and has therefore become a promising treatment for MIRI. This paper reviews the mechanism of hydrogen for the treatment of MIRI and the preliminary prospect of its clinical application in the future.

Key words: Myocardial ischemia-reperfusion injury, Hydrogen, Oxidative stress, Inflammation, Apoptosis

Minjie Zhang, Xiaoshan Zhang, Shasha Duan, Yilu Shi, Jie Zhao, Tianhao Bai, Yaxi Wang. Hydrogen for treatment of myocardial ischemia-reperfusion injury: mechanism and prospect[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 744-748.

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