Value of cell block technique in pathological diagnosis of papillary thyroid carcinoma by fine needle aspiration

doi:10.3877/cma.j.issn.1674-0785.2023.10.008

Abstract

Abstract:

Objective

To explore the value of cell block technique in thyroid fine needle aspiration to improve the accuracy of pathological diagnosis of thyroid diseases.

Methods

One hundred and thirteen cases of papillary thyroid carcinoma from Hebei General Hospital were randomly selected, and routine cytological smears and cell embedding were performed after fine-needle aspiration. The diagnostic results were confirmed by postoperative pathological results.

Results

There was a statistically significant difference in the degree of dissatisfaction between the cell block group (1/113, 0.9%) and the conventional smear group (10/113, 8.8%). In terms of the diagnostic accuracy for papillary thyroid carcinoma, the positive rate in the cell block group (110/113, 97.3%) was significantly higher than that of the conventional smear group (100/113, 88.5%; P<0.05).

Conclusion

Compared with conventional cell smear, cell block technique has a higher degree of satisfaction and higher diagnostic accuracy. In addition, cell blocks can also be immunohistochemically stained to solve difficult diagnostic problems.

Key words: Cell block, Cell smear, Fine needle aspiration, Papillary thyroid carcinoma

Qian Du, Man Zhang, Li Li, XiaoLi Ma. Value of cell block technique in pathological diagnosis of papillary thyroid carcinoma by fine needle aspiration[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(10): 1071-1074.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlcyszz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0785.2023.10.008

https://zhlcyszz.cma-cmc.com.cn/EN/Y2023/V17/I10/1071

Figures/Tables 5

References 13

1	宋立稳, 王小龙, 程丽霞. 甲状腺结节的规范化诊疗 [J/OL]. 中华临床医师杂志(电子版), 2017, 11(17): 2189-2192. URL
2	Baloch ZW, Tam D, Langer J, et al. Ultrasound-guided fine-needle aspiration biopsy of the thyroid: role of on-site assessment and multiple cytologic preparations [J]. Diagn Cytopathol, 2000, 23: 425-429.
3	Nagarajan N, Schneider EB, Ali SZ, et al. How do liquid-based preparations of thyroid fine-needle aspiration compare with conventional smears? An analysis of 5475 specimens [J]. Thyroid, 2015, 25: 308-313.
4	Khan S, Omar T, Michelow P. Effectiveness of the cell block technique in diagnostic cytopathology [J]. J Cytol, 2012, 29: 177-182.
5	Wagner DG, Russell DK, Benson JM, et al. Cellient automated cell block versus traditional cell block preparation: a comparison of morphologic features and immunohistochemical staining [J]. Diagn Cytopathol, 2011, 39: 730-736.
6	Sanchez N, Selvaggi SM. Utility of cell blocks in the diagnosis of thyroid aspirates [J]. Diagn Cytopathol, 2006, 34: 89-92.
7	Nassar A, Cohen C, Siddiqui MT. Utility of millipore filter and cell block in thyroid needle aspirates: which method is superior? [J]. Diagn Cytopathol, 2007, 35: 34-38.
8	Nam-Goong IS, Kim HY, Gong G, et al. Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings [J]. Clin Endocrinol (Oxf), 2004, 60: 21-28.
9	Haugen BR, Alexander EK, Bible KC, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer [J]. Thyroid, 2016, 26: 1-133.
10	Nathan NA, Narayan E, Smith MM, et al. Cell block cytology. Improved preparation and its efficacy in diagnostic cytology [J]. Am J Clin Pathol, 2000, 114: 599-606.
11	Nikiforov YE, Ohori NP, Hodak SP, et al. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples [J]. J Clin Endocrinol Metab, 2011, 96(11): 3390-3397.
12	Lithwick-Yanai G, Dromi N, Shtabsky A, et al. Multicentre validation of a microRNA-based assay for diagnosing indeterminate thyroid nodules utilising fine needle aspirate smears [J]. J Clin Pathol, 2017, 70: 500-507.
13	Poller DN, Glaysher S, Agrawal A, et al. BRAF V600 co-testing in thyroid FNA cytology: short-term experience in a large cancer centre in the UK [J]. J Clin Pathol, 2014, 67: 684-689.

组	不满意（例）	满意（例）	“不满意”率（%）	合计	统计值
细胞蜡块法	1	112	0.9%	113	χ²=7.74
常规涂片	10	103	8.8%	113	P=0.0054

组	不满意（例）	满意（例）	“不满意”率（%）	合计	统计值
细胞蜡块法	1	112	0.9%	113	χ²=7.74
常规涂片	10	103	8.8%	113	P=0.0054

组	阳性	阴性	阳性率（%）	合计	统计值
细胞蜡块	110	3	97.3%	113	χ²=6.726
常规涂片	100	13	88.5%	113	P=0.0095

组	阳性	阴性	阳性率（%）	合计	统计值
细胞蜡块	110	3	97.3%	113	χ²=6.726
常规涂片	100	13	88.5%	113	P=0.0095

组	制作过程	制作时间	技术要求	费用	诊断效率
细胞蜡块	复杂	长	高	高	高
常规涂片	简单	短	低	低	低

Please choose a citation manager

Content to export