Abstract:

Being based on the three traditional Chinese medicines Tripterygium wilfordii Hook. f., Tripterygium hypoglaucum (Levl.) Hutch, and Tripterygium regelii Spragus et Takeda, integrating the knowledge of Chinese medicines and compound prescriptions, and combining the data from the existing literature database, ADMETlab 2.0 database, Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database (TCMSP), The Encyclopedia of Traditional Chinese Medicine database (ETCM), and the 2020 edition of Chinese Pharmacopoeia, a basic database was generated. Then, the database content was re-associated and constructed. The Tripterygium wilfordii database (TWD) collects a total of 14 related Chinese patent medicine prescriptions, 33 related medicinal materials, more than 4000 related chemical components, more than 2000 related disease targets, and 20 related diseases, covering the origin of medicinal materials, flavor and meridian tropism, index components, incompatibility, modern application, and other dimensions. It includes five sub-databases of medicinal materials, prescriptions, ingredients, targets, and diseases and one analysis system. Hyperlinks are established between the primary database and the secondary table to realize the interactive retrieval of data from each database table. By collation and integration of professional knowledge, combined with the professional frontier technology of the database, the TWD was established in a bilingual (Chinese-English) form, presenting the traditional Chinese medicine information of Tripterygium wilfordii systematically, accurately, comprehensively, synthetically, and visually, laying the foundation for the development and clinical application of Tripterygium wilfordii botanical drugs and promoting the internationalization of Tripterygium wilfordii research.

Key words: Tripterygium Wilfordii, Database, Bilingual (Chinese-English) version, Database of Chinese medicines and compound prescriptions, Visualization