To investigate the clinical characteristics, skin wound manifestations, and treatment methods of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).

A retrospective analysis was conducted on the clinical characteristics, skin wound manifestations, and treatment of six patients diagnosed with SJS/TEN at the Department of Reconstructive Surgery of the Peking University Shougang Hospital from August 2022 to August 2023.

The main clinical features of the six cases of SJS/TEN were varying degrees of skin exfoliation, involvement of mucous membranes, abnormalities in liver and kidney function, electrolyte imbalance, and hypoproteinemia. Three cases (50%) had a SCROETEN score of ≥3. All patients received systemic glucocorticoid therapy at a dose of 1.5~2 mg/kg/day for 7~10 days, and gamma-globulin therapy at a dose of 400 mg/kg/day for 3~5 days after admission. Systemic debridement and dressing changes were performed on the affected areas of the skin and mucosa, and skin wound management was strengthened. All six patients recovered and were discharged.

Both SJS/TEN present with varying degrees of systemic skin and mucosal damage. On the basis of controlling the disease with sufficient systemic and local glucocorticoids, selecting appropriate skin wound treatment methods and strengthening skin care can effectively improve the therapeutic effect and prognosis.