Progress in diagnosis and treatment of hepatoid adenocarcinoma of the lung

doi:10.3877/cma.j.issn.1674-0785.2024.01.013

Abstract

Abstract:

Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive pathological subtype of lung cancer. With histological characteristics resembling those of hepatocellular carcinoma, HAL predominantly affects elderly men. The development of HAL may be associated with abnormal development of primitive pluripotent stem cells during embryonic development. Its diagnosis and differential diagnosis rely on the exclusion of hepatoid adenocarcinoma in other locations through imaging studies, as well as comprehensive evaluation based on lesion morphology and immunohistochemistry. Serum alpha-fetoprotein (AFP) levels are associated with disease activity, but the relationship between AFP and prognosis requires more supporting data. HAL patients have a worse prognosis compared to non-small cell lung cancer patients, and there are currently no unified treatment guidelines. Treatment recommendations often refer to those for lung adenocarcinoma. This article aims to provide a comprehensive review of the progress in the diagnosis and treatment of HAL, in order to enhance understanding of this unique solid tumor and improve its clinical management.

Key words: Hepatoid adenocarcinoma, Lung neoplasm, Clinical pathology, Pathogenesis

Xuefen Chen, Hongyu Wei, Qixiang Sun, Hua Zhao, Ping Yan, Chen Gong. Progress in diagnosis and treatment of hepatoid adenocarcinoma of the lung[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(01): 83-86.

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